+ Site Statistics
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Oxidative stress in atherosclerosis development: the central role of LDL and oxidative burst

Oxidative stress in atherosclerosis development: the central role of LDL and oxidative burst

Endocrine, Metabolic and Immune Disorders Drug Targets 12(4): 351-360

The involvement of both oxidative stress and hyperlipaemia in atherosclerosis development is well established. Oxidative burst is an innate immune response to infection, the latter being associated also with marked changes in lipid and lipoprotein metabolism, aimed to neutralize endotoxin toxic effects. On the other hand, lipid overload may increase lipopolysaccharide circulating levels and oxidative stress. Whilst these changes may be beneficial from the perspective of host defense, if they become chronic, they likely increase the risk of atherosclerosis. In particular, oxidation of lipoproteins, resulting from an imbalance of the pro- and antioxidant equilibrium, is involved in the pathologic process of atherosclerosis, changing cellular functions. Lipid oxidation, induced by leukocytes derived reactive oxygen species, can amplify foam cell formation through oxidized low density lipoproteins LDL (oxLDL) formation and uptake. The main enzymes, operating during oxidative burst, involved in LDL oxidation are NADPH oxidase and myeloperoxidase. In vitro studies have shown that oxLDL are able to induce many proatherogenic processes, including modulation of oxidative burst. OxLDL may also induce maturation of dendritic cells and regulate the shift from classical (M1) to alternative (M2) macrophage activation and from T helper 1 to T helper 2 response, suggesting that these could act as a bridge between innate and adaptative immunity, both involved in plaque development. Understanding the relationship between oxLDL and leukocyte oxidative burst helps to explain the involvement of innate immune responses in the early phases of atherosclerosis. The present review focuses on this interplay.

(PDF emailed within 1 workday: $29.90)

Accession: 054827082

Download citation: RISBibTeXText

PMID: 23061409

Related references

Oxidative Stress in Atherosclerosis Development The Central Role of LDL and Oxidative Burst. Endocrine Metabolic & Immune Disorders - Drug Targets 12(4): 351-360, 2012

Measurement and Clinical Significance of Lipid Peroxidation as a Biomarker of Oxidative Stress: Oxidative Stress in Diabetes, Atherosclerosis, and Chronic Inflammation. Antioxidants 8(3), 2019

Role of oxidative stress induced by hydrogen peroxide on initiation and development of atherosclerosis in mature female rats. Iraqi Journal of Veterinary Sciences 20(1): Ar139-Ar151, 2006

The heat shock transcription factor PsHSF1 of Phytophthora sojae is required for oxidative stress tolerance and detoxifying the plant oxidative burst. Environmental Microbiology 17(4): 1351-1364, 2015

CYP2C8-derived epoxyeicosatrienoic acids decrease oxidative stress-induced endothelial apoptosis in development of atherosclerosis: Role of Nrf2 activation. Journal of Huazhong University of Science and Technology. Medical Sciences 35(5): 640-645, 2016

Macrophage oxidative burst and related cytotoxicity 2. differential sensitivity of erythrocytes from various animals to oxidative burst dependent lysis. Comparative Biochemistry and Physiology A 80(2): 163-166, 1985

Physiological mechanisms of a sub-systemic oxidative burst triggered by elicitor-induced local oxidative burst in potato tuber slices. Plant & Cell Physiology 39(11): 1218-1225, 1998

The role of oxidative stress in atherosclerosis. Hellenic Journal of Cardiology 50(5): 402-409, 2009

Role of oxidative stress in atherosclerosis. American Journal of Cardiology 91(3A): 7A-11A, February 6, 2003

Role of oxidative stress in pathogenesis of atherosclerosis. Georgian Medical News 2008(163): 54-57, 2008

The role of oxidative stress and autophagy in atherosclerosis. Oxidative Medicine and Cellular Longevity 2015: 130315, 2015

The effects of oxidative stress on the development of atherosclerosis. Biological Chemistry 2019, 2019

Regulatory role of mitochondria in oxidative stress and atherosclerosis. World Journal of Cardiology 2(6): 150-159, 2010

Role of oxidative stress in atherosclerosis and cardiovascular diseases. Acta Haematologica (Basel) 103(Supplement 1): 101, 2000

The role of oxidative stress in atherosclerosis: the hope and the hype. Transactions of the American Clinical and Climatological Association 110: 119-29; Discussion 129-30, 1999