+ Site Statistics
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Oxidative stress of platelet and atherosclerosis

Oxidative stress of platelet and atherosclerosis

Sheng Li Ke Xue Jin Zhan 42(1): 33-38

Most platelet-derived oxidants are produced through NAD (P) H-oxidase enzyme system. There are antioxidants such as superoxide dismutase and reduced glutathione in platelet. Oxidative stress alters platelet functions via regulation of platelet aggregation phase, impact on platelet nitric oxide and alpha II bbeta3 integrin, and imbalance between reduced and oxidized glutathione in platelet. Activated platelet by oxidative stress can influence blood vessel endothelium cell function, and worsen atherosclerosis through CD40 ligand. LDL is modified to oxidized LDL by platelets which can trigger foam cell formation. Some drugs with therapeutic intervention to reduce oxidative stress of platelet will be of use for atherosclerosis treatment.

(PDF emailed within 1 workday: $29.90)

Accession: 054827608

Download citation: RISBibTeXText

PMID: 21595185

Related references

Oxidative stress and platelet activation in diabetes mellitus and adhesion molecules influencing atherosclerosis. Diabetes Research & Clinical Practice 30(SUPPL ): S141-S142, 1996

Generation of platelet-activating factor (PAF)-like phospholipids in blood circulation under elevated oxidative stress: Its pathological significance on atherosclerosis. Journal of Clinical Biochemistry and Nutrition 34(1): 35-42, 2003

Measurement and Clinical Significance of Lipid Peroxidation as a Biomarker of Oxidative Stress: Oxidative Stress in Diabetes, Atherosclerosis, and Chronic Inflammation. Antioxidants 8(3), 2019

Oxidative stress in atherosclerosis development: the central role of LDL and oxidative burst. Endocrine, Metabolic and Immune Disorders Drug Targets 12(4): 351-360, 2013

Oxidative Stress in Atherosclerosis Development The Central Role of LDL and Oxidative Burst. Endocrine Metabolic & Immune Disorders - Drug Targets 12(4): 351-360, 2012

Platelet count, not oxidative stress, may contribute to inadequate platelet inhibition by aspirin. International Journal of Cardiology 143(1): 43-50, 2010

Treatment of Platelet Concentrates with the Mirasol Pathogen Inactivation System Modulates Platelet Oxidative Stress and NF-κB Activation. Transfusion Medicine and HemoTherapy 42(3): 167-173, 2015

Increased platelet oxidative metabolism, blood oxidative stress and neopterin levels after ultra-endurance exercise. Journal of Sports Sciences 32(1): 22-30, 2015

High-dose folate may improve platelet function in acute coronary syndrome and other pathologies associated with increased platelet oxidative stress. Medical Hypotheses 69(1): 12-19, 2007

Platelet and Red Blood Cell Counts, as well as the Concentrations of Uric Acid, but Not Homocysteinaemia or Oxidative Stress, Contribute Mostly to Platelet Reactivity in Older Adults. Oxidative Medicine and Cellular Longevity 2019: 9467562, 2019

Increased inflammation, endoplasmic reticulum stress and oxidative stress in endothelial and macrophage cells exacerbate atherosclerosis in ApoCIII transgenic mice. Lipids in Health and Disease 17(1): 220, 2018

Oxidative stress and atherosclerosis. Nihon Rinsho. Japanese Journal of Clinical Medicine 55 Suppl: 752-756, 1997

Atherosclerosis and oxidative stress. Histology and Histopathology 23(3): 381-390, 2007

Oxidative stress and atherosclerosis. Orvosi Hetilap 156(28): 1115-1119, 2015

Atherosclerosis and oxidative stress. Nihon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics 45(3): 287-290, 2008