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P,N,N-pincer nickel-catalyzed cross-coupling of aryl fluorides and chlorides

P,N,N-pincer nickel-catalyzed cross-coupling of aryl fluorides and chlorides

Organic and Biomolecular Chemistry 12(33): 6414-6424

P,N,N-Pincer nickel complexes [Ni(Cl){N(2-R2PC6H4)(2'-Me2NC6H4)}] (R = Ph, 3a; R = Pr(i), 3b; R = Cy, 3c) were synthesized and their catalysis toward the Kumada or Negishi cross-coupling reaction of aryl fluorides and chlorides was evaluated. Complex 3a effectively catalyzes the cross-coupling of (hetero)aryl fluorides with aryl Grignard reagents at room temperature. Complex 3a also catalyzes the cross-coupling of (hetero)aryl chlorides and arylzinc reagents at 80 °C with low catalyst loadings and good functional group compatibility.

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Accession: 054831063

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PMID: 25012049

DOI: 10.1039/c4ob01041h

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