+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

PI3K/AKT/PTEN pathway as a target for Crohn's disease therapy (Review)



PI3K/AKT/PTEN pathway as a target for Crohn's disease therapy (Review)



International Journal of Molecular Medicine 35(1): 10-16



The pathogenesis of inflammatory bowel disease (IBD), including Crohn's disease, is a subject of increasing interest. Loss-of-function mutations in nucleotide-binding oligomerization domain-containing protein 2 (NOD2) are strong genetic factors linked to Crohn's disease, which eventually leads to an excessive mucosal inflammatory response directed against components of normal gut microbiota. Reactive oxygen species (ROS) play an important role in inflammation processes, as well as in transduction of signals from receptors for several cytokines, such as tumor necrosis factor α (TNFα). ROS activate nuclear factor-κB (NF-κB) via IκB kinase (IKK) through the PI3K/AKT/PTEN pathway. Therefore, this pathway is recognized to play a key role in Crohn's disease. Loss of function has been demonstrated to occur as an early event in a wide variety of diseases. Given this prevalent involvement in a number of diseases, the molecular development that modulates this pathway has been the subject of several studies. In addition, it has been the focus of extensive research and drug discovery activities. A better understanding of the molecular assemblies may reveal novel targets for the therapeutic development against Crohn's disease.

(PDF emailed within 0-6 h: $19.90)

Accession: 054837731

Download citation: RISBibTeXText

PMID: 25352295

DOI: 10.3892/ijmm.2014.1981


Related references

Roles of PI3K/AKT/PTEN Pathway as a Target for Pharmaceutical Therapy. Open Medicinal Chemistry Journal 7: 23-29, 2013

Activation of PI3K/Akt/mTOR signaling pathway triggered by PTEN downregulation in the pathogenesis of Crohn's disease. Journal of Digestive Diseases 14(12): 662-669, 2014

Combinatorial therapy with adenoviral-mediated PTEN and a PI3K inhibitor suppresses malignant glioma cell growth in vitro and in vivo by regulating the PI3K/AKT signaling pathway. Journal of Cancer Research and Clinical Oncology 143(8): 1477-1487, 2017

The PI3K/Akt/PTEN/mTOR pathway: a fruitful target for inducing cell death in rheumatoid arthritis?. Future Medicinal Chemistry 7(9): 1137-1147, 2016

MicroRNAs and the PTEN/PI3K/Akt pathway in gastric cancer (Review). Oncology Reports 2019, 2019

Mutations in the PI3K/PTEN/TSC2 pathway contribute to mammalian target of rapamycin activity and increased translation under hypoxic conditions. Cancer Research 66(3): 1561-1569, 2006

Gene alterations in the PI3K/PTEN/AKT pathway as a mechanism of drug-resistance (review). International Journal of Oncology 40(3): 639-644, 2012

Role of the PTEN/PI3K/VEGF pathway in the development of Kawasaki disease. Experimental and Therapeutic Medicine 11(4): 1318-1322, 2016

PTEN regulation of the proliferation and differentiation of auditory progenitors through the PTEN/PI3K/Akt-signaling pathway in mice. Neuroreport 25(3): 177-183, 2014

PTEN augments staurosporine-induced apoptosis in PTEN-null Ishikawa cells by downregulating PI3K/Akt signaling pathway. Cell Death & Differentiation 9(4): 414-420, April, 2002

Roles for PI3K/AKT/PTEN Pathway in Cell Signaling of Nonalcoholic Fatty Liver Disease. Isrn Endocrinology 2013: 472432-472432, 2013

Biomarker-directed therapy of squamous carcinomas of the head and neck: targeting PI3K/PTEN/mTOR pathway. Journal of Clinical Oncology 31(9): E137-E140, 2013

Inhibition of PTEN Attenuates Endoplasmic Reticulum Stress and Apoptosis via Activation of PI3K/AKT Pathway in Alzheimer's Disease. Neurochemical Research 42(11): 3052-3060, 2017

Adult B-cell acute lymphoblastic leukemia cells display decreased PTEN activity and constitutive hyperactivation of PI3K/Akt pathway despite high PTEN protein levels. Haematologica 99(6): 1062-1068, 2015

Dysregulated PI3K/Akt/PTEN pathway is a marker of a short disease-free survival in node-negative breast carcinoma. Breast Diseases: A Year Book Quarterly 21(1): 47-48, 2010