+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

PPT and VES-13 in elderly patients with cancer: evaluation in multidimensional geriatric assessment and prediction of survival



PPT and VES-13 in elderly patients with cancer: evaluation in multidimensional geriatric assessment and prediction of survival



Journal of Geriatric Oncology 5(4): 415-421



The multidimensional geriatric assessment (MGA) detects impairments in the elderly and forms the basis for individualized treatment algorithms. Screening tools have been developed to detect patients in need of a full assessment. The aim of this pilot study was to evaluate the discriminative power and the prognostic impact of the screening scores for the Physical Performance Test (PPT) and the Vulnerable Elders Survey-13 (VES-13). In 77 patients with cancer aged ≥60years (median 74years) from the Department of Internal Medicine V, Innsbruck Medical University, VES-13 and PPT were performed and compared with data from MGA and clinical outcomes. Overall, of the 77 patients 70% was deemed impaired, as defined by impairments in two or more scores of the MGA. The VES-13 showed 42% to be impaired, the PPT 79%. Using a cut-off of ≤19, the PPT exhibited better discriminative power than did the standard PPT (≤20). Sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) of VES-13, PPT≤20 and PPT≤19 in the detection of impairments were 56% (88%, 82%), 91% (45%, 75%), 94% (80%, 89%), and 45% (60%, 63%) respectively. The area under the curve was 0.73 (0.67, 0.79), respectively. Both impaired VES-13 and PPT significantly correlated with an unfavorable overall survival in both uni- and multivariate analysis. PPT (≤19) reveals favorable sensitivity, NPV and overall accuracy in elderly patients with cancer. Still, the NPV is too low to sufficiently discriminate between fit and frail patients. Both PPT and VES-13 are useful predictors for survival.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 054840688

Download citation: RISBibTeXText

PMID: 25242575

DOI: 10.1016/j.jgo.2014.08.005


Related references

Multidimensional geriatric assessment in treatment decision in elderly cancer patients: 6-year experience in an outpatient geriatric oncology service. Critical Reviews in Oncology/Hematology 68(2): 157-164, 2008

How much does performance status correlate with multidimensional geriatric assessment in elderly patients with cancer (Epc)?. European Journal of Cancer 31: S255-S256, 1995

Multidimensional geriatric evaluation in elderly cancer patients: a practical approach. European Journal of Cancer Care 13(5): 424-433, 2004

BODE index or geriatric multidimensional assessment for the prediction of very-long-term mortality in elderly patients with chronic obstructive pulmonary disease? a prospective cohort study. Age and Ageing 43(4): 553-558, 2014

Comprehensive geriatric assessment in elderly cancer patients Impact on overall survival and progression-free survival. Journal of the American Geriatrics Society 47(9): S30, 1999

An attempt to correlate a "Multidimensional Geriatric Assessment" (MGA), treatment assignment and clinical outcome in elderly cancer patients: results of a phase II open study. Critical Reviews in Oncology/Hematology 66(1): 75-83, 2008

Alterations in comprehensive geriatric assessment decrease survival of elderly patients with cancer. European Journal of Cancer 90: 10-18, 2018

Alterations in comprehensive geriatric assessment decrease survival of elderly patients with cancer. European Journal of Cancer 90: 10-18, 2018

Prediction of Postoperative Complications Following Elective Surgery in Elderly Patients with Colorectal Cancer Using the Comprehensive Geriatric Assessment. Digestive Surgery 33(6): 470-477, 2016

Serial comprehensive geriatric assessment in elderly head and neck cancer patients undergoing curative radiotherapy identifies evolution of multidimensional health problems and is indicative of quality of life. European Journal of Cancer Care 23(3): 401-412, 2014

Geriatric multidimensional assessment for elderly patients with acute respiratory diseases. European Journal of Internal Medicine 25(4): 304-311, 2014

Geriatric Assessment Predicts Survival and Competing Mortality in Elderly Patients with Early Colorectal Cancer: Can It Help in Adjuvant Therapy Decision-Making?. Oncologist 22(8): 934-943, 2017

Does multidimensional geriatric assessment influence the prescription of adjuvant chemotherapy to elderly women with early breast cancer in a multivariate model?. Journal of Clinical Oncology 26(15_Suppl): 20541-20541, 2016

Risk Evaluation of Postoperative Delirium Using Comprehensive Geriatric Assessment in Elderly Patients with Esophageal Cancer. World Journal of Surgery 40(11): 2705-2712, 2016

Multidimensional Geriatric Prognostic Index, Based on a Geriatric Assessment, for Long-Term Survival in Older Adults in Korea. Plos one 11(1): E0147032, 2016