+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Part 2: Quantitative proton T2 and sodium magnetic resonance imaging to assess intervertebral disc degeneration in a rabbit model

Part 2: Quantitative proton T2 and sodium magnetic resonance imaging to assess intervertebral disc degeneration in a rabbit model

Spine 37(18): E1113-9

Comparison of sodium concentration ([Na]) and proton T2 relaxation time between normal and degenerated discs in a rabbit model. The purpose of this article was to evaluate quantitative [Na] and T2 characteristics of discs associated with degenerative changes. Intervertebral disc degeneration is a common chronic condition that may lead to back pain, limited activity, and disability. Noninvasive imaging method to detect early intervertebral disc degeneration is vital to follow disease progression and guide clinical treatment and management. Dual-tuned magnetic resonance imaging of rabbit discs was performed using 3T. Thirteen rabbits were included in the study; 6 control rabbits (24 normal discs) and 7 rabbits with annular puncture-induced disc degeneration (9 degenerated discs, 19 intact internal-control discs). Dual-tuned magnetic resonance imaging of discs was performed at baseline and 12-week poststab. [Na] and T2 were measured and compared among 3 groups of discs. The mean [Na] were 274.8 ± 40.2 mM for the normal discs, 247.2 ± 27.7 mM for the internal-control discs, and 190.6 ± 19.1 mM for the degenerated discs. The corresponding T2 for 3 groups were 97.1 ± 12.1 ms, 93.7 ± 11.9 ms, and 79.0 ± 9.1 ms, respectively. The [Na] is highly correlated with the T2 in the degenerated discs (r = 0.90, P < 0.01). The mean percent decreases from the normal to degenerated discs were in 30.6% in [Na] and 18.6% in T2, whereas those from the internal-control to degenerated discs were 22.9% in [Na] and 15.6% in T2. Although both [Na] and T2 changes in discs were associated with the disc-punctured rabbits, greater change in [Na] is observed at 12-week poststab compared with T2 change. Because T2 and [Na] reflect different disc properties, performing both imaging under same condition will be helpful in the evaluation of disc degeneration.

Please choose payment method:

(PDF emailed within 0-6 h: $19.90)

Accession: 054870360

Download citation: RISBibTeXText

PMID: 22511229

DOI: 10.1097/brs.0b013e3182583447

Related references

Evaluation of Lumbar Intervertebral Disc Degeneration Using T1ρ and T2 Magnetic Resonance Imaging in a Rabbit Disc Injury Model. Asian Spine Journal 12(2): 317-324, 2018

One-Stage Positron Emission Tomography and Magnetic Resonance Imaging to Assess Mesenchymal Stem Cell Survival in a Canine Model of Intervertebral Disc Degeneration. Stem Cells and Development 26(18): 1334-1343, 2017

Multimodal quantitative magnetic resonance imaging for lumbar intervertebral disc degeneration. Experimental and Therapeutic Medicine 14(3): 2078-2084, 2017

Multi-parameter evaluation of lumbar intervertebral disc degeneration using quantitative magnetic resonance imaging techniques. American Journal of Translational Research 10(2): 444-454, 2018

Assessment of intervertebral disc degeneration based on quantitative magnetic resonance imaging analysis: an in vivo study. Spine 39(6): E369, 2014

Multifidus Muscles Lipid Content Is Associated with Intervertebral Disc Degeneration: A Quantitative Magnetic Resonance Imaging Study. Asian Spine Journal 13(4): 601-607, 2019

Quantitative magnetic resonance imaging for diagnosis of intervertebral disc degeneration of the cervico-thoracic junction: a pilot study. American Journal of Translational Research 10(3): 925-935, 2018

Part 1: Dual-tuned proton/sodium magnetic resonance imaging of the lumbar spine in a rabbit model. Spine 37(18): E1106, 2012

Quantitative T2 magnetic resonance imaging compared to morphological grading of the early cervical intervertebral disc degeneration: an evaluation approach in asymptomatic young adults. Plos one 9(2): E87856, 2014

A porcine model of intervertebral disc degeneration induced by annular injury characterized with magnetic resonance imaging and histopathological findings. Laboratory investigation. Journal of Neurosurgery. Spine 8(5): 450-457, 2008

Characterization of intervertebral disc aging: longitudinal analysis of a rabbit model by magnetic resonance imaging, histology, and gene expression. Spine 33(17): 1821-1828, 2008

Percutaneous inoculated rabbit model of intervertebral disc space infection: magnetic resonance imaging features with pathological correlation. Joint Bone Spine 75(4): 465-470, 2008

Magnetic resonance imaging evaluation of L5-s1 intervertebral disc degeneration in Japanese women. Asian Spine Journal 8(5): 581-590, 2014

A model for studying intervertebral disc degeneration with magnetic resonance and a nucleotome. Investigative Radiology 24(5): 407-409, 1989

Early intervertebral disc degeneration changes in asymptomatic weightlifters assessed by t1ρ-magnetic resonance imaging. Spine 39(22): 1881-1886, 2014