EurekaMag
+ Translate
+ Most Popular
The pigeon tick (Argas reflexus): its biology, ecology, and epidemiological aspects
Prevalence of hemoglobin abnormalities in Kebili (Tunisian South)
Lipogranuloma: a preventable complication of dacryocystorhinostomy
Value of basal plasma cortisol assays in the assessment of pituitary-adrenal insufficiency
Bees from the Belgian Congo. The acraensis group of Anthophora
Placing gingival retraction cord
Total serum IgE, allergy skin testing, and the radioallergosorbent test for the diagnosis of allergy in asthmatic children
Acariens plumicoles Analgesoidea parasites des oiseaux du Maroc
Injuries of terminal phalanges of the fingers in children
Biology of flowering and nectar production in pear (Pyrus communis)
Das Reliktvorkommen der Aspisviper (Vipera aspis L.) im Schwarzwald
Hydrological modelling of drained blanket peatland
Pathologic morphology and clinical significance of the anomalous origin of the left circumflex coronary artery from the right coronary artery. General review and autopsy analysis of 30 cases
Cyto genetic analyses of lymphocyte cultures after exposure to calcium cyclamate
Axelrodia riesei, a new characoid fish from Upper Rio Meta in Colombia With remarks concerning the genus Axelrodia and description of a similar, sympatric, Hyphessobrycon-species
Favorable evolution of a case of tuberculosis of pancreas under antibiotic action
RIFM fragrance ingredient safety assessment, Valencene, CAS Registry Number 4630-07-3
Parenteral microemulsions: an overview
Temperate pasture: management for grazing and conservation
Evaluation of a new coprocessed compound based on lactose and maize starch for tablet formulation
Thermal expansion and cracking of three confined water-saturated igneous rocks to 800C
Revision of the genera of the tribe Stigmoderini (Coleoptera: Buprestidae) a discussion of phylogenetic relationships
Anal tuberculosis. Report of a case
Gastric tuberculosis in the past and present
Adaptive responses of the cardiovascular system to prolonged spaceflight conditions: assessment with Holter monitoring

Partial pneumonectomy of telomerase null mice carrying shortened telomeres initiates cell growth arrest resulting in a limited compensatory growth response


Partial pneumonectomy of telomerase null mice carrying shortened telomeres initiates cell growth arrest resulting in a limited compensatory growth response



American Journal of Physiology. Lung Cellular and Molecular Physiology 300(6): L898-L909



ISSN/ISBN: 1040-0605

PMID: 21460122

DOI: 10.1152/ajplung.00409.2010

Telomerase mutations and significantly shortened chromosomal telomeres have recently been implicated in human lung pathologies. Natural telomere shortening is an inevitable consequence of aging, which is also a risk factor for development of lung disease. However, the impact of shortened telomeres and telomerase dysfunction on the ability of lung cells to respond to significant challenge is still largely unknown. We have previously shown that lungs of late generation, telomerase null B6.Cg-Terc(tm1Rdp) mice feature alveolar simplification and chronic stress signaling at baseline, a phenocopy of aged lung. To determine the role telomerase plays when the lung is challenged, B6.Cg-Terc(tm1Rdp) mice carrying shortened telomeres and wild-type controls were subjected to partial pneumonectomy. We found that telomerase activity was strongly induced in alveolar epithelial type 2 cells (AEC2) of the remaining lung immediately following surgery. Eighty-six percent of wild-type animals survived the procedure and exhibited a burst of early compensatory growth marked by upregulation of proliferation, stress response, and DNA repair pathways in AEC2. In B6.Cg-Terc(tm1Rdp) mice carrying shortened telomeres, response to pneumonectomy was characterized by decreased survival, diminished compensatory lung growth, attenuated distal lung progenitor cell response, persistent DNA damage, and cell growth arrest. Overall, survival correlated strongly with telomere length. We conclude that functional telomerase and properly maintained telomeres play key roles in both long-term survival and the early phase of compensatory lung growth following partial pneumonectomy.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 054871958

Download citation: RISBibTeXText

Related references

Compensatory growth of the lung following partial pneumonectomy. Experimental Lung Research 14(2): 157-182, 1988

Collagen metabolism during compensatory lung growth after partial pneumonectomy. Biochemical Society Transactions 15(6): 1180-1181, 1987

Telomerase Cajal body protein 1 depletion inhibits telomerase trafficking to telomeres and induces G 1 cell cycle arrest in A549 cells. Oncology Letters 8(3): 1009-1016, 2014

Neoalveolarisation contributes to compensatory lung growth following pneumonectomy in mice. European Respiratory Journal 31(3): 515-522, 2008

Assembly of mutant-template telomerase RNA into catalytically active telomerase ribonucleoprotein that can act on telomeres is required for apoptosis and cell cycle arrest in human cancer cells. Cancer Research 66(11): 5763-5771, 2006

Telomeres and telomerase: broad effects on cell growth. Current Opinion in Genetics and Development 9(2): 218-224, 1999

Antisense telomerase induced cell growth inhibition, cell cycle arrest and telomerase activity down-regulation in gastric and colon cancer cells. Anticancer Research 23(1A): 465-469, 2003

Aberrant fertilization and early development of germs cells with dysfunctional telomeres from telomerase-null mice. Biology of Reproduction 66(Suppl 1): 161-162, 2002

Compensatory kidney growth in estrogen receptor-alpha null mice. American Journal of Physiology Renal Physiology 290(2): F319-F323, 2006

Compensatory kidney growth in estrogen receptor-alpha null mice. American Journal of Physiology. Renal Physiology 290(2): F319-F323, 2006

Decreased B16F10 melanoma growth and impaired vascularization in telomerase-deficient mice with critically short telomeres. Cancer Research 62(2): 552-559, 2002

Compensatory synaptic growth in the rod terminals as a sequel to partial photoreceptor cell loss in the retina of chimaeric mice. Development 114(3): 797-803, 1992

Nuclear factor-kappa B influences early phase of compensatory lung growth after pneumonectomy in mice. Journal of Biomedical Science 24(1): 41, 2017

Longitudinal, noninvasive monitoring of compensatory lung growth in mice after pneumonectomy via (3)He and (1)H magnetic resonance imaging. American Journal of Respiratory Cell and Molecular Biology 49(5): 697-703, 2013

Compensatory responses in mice carrying a null mutation for Ins1 or Ins2. Diabetes 50(Suppl): S150-S153, 2001