Section 55
Chapter 54,880

Pathogenesis and treatment of pruritus in cholestasis

Kremer, A.E.; Beuers, U.; Oude-Elferink, R.P.J.; Pusl, T.

Drugs 68(15): 2163-2182


ISSN/ISBN: 0012-6667
PMID: 18840005
DOI: 10.2165/00003495-200868150-00006
Accession: 054879634

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Pruritus is an enigmatic, seriously disabling symptom accompanying cholestatic liver diseases and a broad range of other disorders. Most recently, novel itch-specific neuronal pathways, itch mediators and their relevant receptors have been identified. In addition, new antipruritic therapeutic strategies have been developed and/or are under evaluation. This review highlights recent experimental and clinical findings focusing on the pathogenesis and actual treatment of pruritus in cholestatic liver disease. Evidence-based therapeutic recommendations, including the use of anion exchange resins cholestyramine, colestipol and colesevelam, the microsomal enzyme inducer rifampicin, the opioid receptor antagonists naltrexone and naloxone, and the serotonin reuptake inhibitor sertraline, are provided.

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