EurekaMag
+ Most Popular
Cunninghamia lanceolata plantations in China
Mammalian lairs in paleo ecological studies and palynology
Studies on technological possibilities in utilization of anhydrous milk fat for production of recombined butter-like products
Should right-sided fibroelastomas be operated upon?
Large esophageal lipoma
Apoptosis in the mammalian thymus during normal histogenesis and under various in vitro and in vivo experimental conditions
Poissons characoides nouveaux ou non signales de l'Ilha do Bananal, Bresil
Desensitizing efficacy of Colgate Sensitive Maximum Strength and Fresh Mint Sensodyne dentifrices
Administration of fluid by subcutaneous infusion: revival of a forgotten method
Tundra mosquito control - an impossible dream?
Schizophrenia for primary care providers: how to contribute to the care of a vulnerable patient population
Geochemical pattern analysis; method of describing the Southeastern limestone regional aquifer system
Incidence of low birth weights in a hospital of Mexico City
Tabanidae
Graded management intensity of grassland systems for enhancing floristic diversity
Microbiology and biochemistry of cheese and fermented milk
The ember tetra: a new pygmy characid tetra from the Rio das Mortes, Brazil, Hyphessobrycon amandae sp. n. (Pisces, Characoidei)
Risk factors of contrast-induced nephropathy in patients after coronary artery intervention
Renovation of onsite domestic wastewater in a poorly drained soil
Observations of the propagation velocity and formation mechanism of burst fractures caused by gunshot
Systolic blood pressure in a population of infants in the first year of life: the Brompton study
Haematological studies in rats fed with metanil yellow
Studies on pasteurellosis. I. A new species of Pasteurella encountered in chronic fowl cholera
Dormancy breaking and germination of Acacia salicina Lindl. seeds
therapy of lupus nephritis. a two-year prospective study

Patient risk stratification using Gleason score concordance and upgrading among men with prostate biopsy Gleason score 6 or 7


Patient risk stratification using Gleason score concordance and upgrading among men with prostate biopsy Gleason score 6 or 7



Urologic Oncology 28(3): 302-307



ISSN/ISBN: 1078-1439

PMID: 19117774

DOI: 10.1016/j.urolonc.2008.09.030

To define the impact of discordant Gleason sum (GS) between prostate biopsy (Pbx) tissue and radical prostatectomy (RP) specimen among men initially diagnosed with Gleason 6 or 7 prostate adenocarcinoma. We evaluated patients diagnosed with GS 6 or 7 and treated primarily with RP. We defined the frequency of GS discordance between Pbx and RP pathology reports. We analyzed pretreatment parameters associated with GS discordance and compared immediate postprostatectomy outcome variables across patient groups defined by their GS and concordance. We then conducted survival analysis for biochemical recurrence across patient groups defined by their GS and concordance status. Among patients with GS 6 on Pbx, 681/1,847 (36.86%) patients were upgraded to GS 7 or higher after RP. Surgical margin, capsular involvement, seminal vesicle, and nodal involvement status were more favorable in patients with concordant Pbx and RP specimen with GS 6 (P < 0.0001). Patients with smaller transrectal ultrasound (TRUS) prostate volume were found to have higher PSA densities and were more likely to be upgraded at RP. Multivariate survival analysis also predicted fewer biochemical recurrence events over time in men with concordant Pbx tissue and RP specimen of GS 6 vs. 6/7 or 7/7 (P = 0.0025) controlling for other relevant covariates. GS discordance between Pbx tissue and RP specimens among prostate cancer patients initially diagnosed with either GS 6 or 7 adenocarcinoma of the prostate is substantial. This discordance has potential clinical significance in predicting oncologic outcomes.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 054889421

Download citation: RISBibTeXText

Related references

Which gleason score should be applied, global or highest gleason score? Grade concordance between extended biopsy and prostatectomy according to modified gleason grading system. European Urology Suppls 7(3): 225, 2008

Predictors of Gleason score upgrading in patients with prostate biopsy Gleason score ≤6. Canadian Urological Association Journal 8(5-6): E342-E346, 2014

Global Gleason score, highest core Gleason score, or weighted Gleason score What Gleason score should be reported in prostate needle biopsies?. Journal of Urology 167(4 Suppl): 224, 2002

Comparison of biochemical relapse-free survival between primary Gleason score 3 and primary Gleason score 4 for biopsy Gleason score 7 prostate cancer. International Journal of Radiation Oncology Biology Physics 73(5): 1439-1445, 2009

Role of multiparametric magnetic resonance imaging to predict postoperative Gleason score upgrading in prostate cancer with Gleason score 3 + 4. World Journal of Urology 39(6): 1825-1830, 2021

Increasing the number of biopsy cores improves the concordance of biopsy Gleason score to prostatectomy Gleason score. Bju International 96(3): 324-327, 2005

Cases Having a Gleason Score 3+4=7 with <5% of Gleason Pattern 4 in Prostate Needle Biopsy Show Similar Failure-free Survival and Adverse Pathology Prevalence to Gleason Score 6 Cases in a Radical Prostatectomy Cohort. American Journal of Surgical Pathology 43(11): 1560-1565, 2019

Cases Having a Gleason Score 3+4=7 with <5% of Gleason Pattern 4 in Prostate Needle Biopsy Show Similar Failure-free Survival and Adverse Pathology Prevalence to Gleason Score 6 Cases in a Radical Prostatectomy Cohort. The American Journal of Surgical Pathology 43(11): 1560-1565, 2019

Diagnostic significance of multiparametric MRi combined with US-fusion guided biopsy of the prostate in patients with increased PSA levels and negative standard biopsy results to detect significant prostate cancer - Correlation with the Gleason score. Korrelation mit dem Gleason Score. NUKLEARMEDIZIN. Nuclear Medicine 56(4): 147-155, 2017

Impact of primary Gleason grade on risk stratification for Gleason score 7 prostate cancers. International Journal of Radiation Oncology Biology Physics 82(1): 200-203, 2012

The values of neutrophil-lymphocyte ratio and/or prostate-specific antigen in discriminating real Gleason score ≥ 7 prostate cancer from group of biopsy-based Gleason score ≤ 6. Bmc Cancer 17(1): 629, 2017

Interobserver agreement of Gleason score and modified Gleason score in needle biopsy and in surgical specimen of prostate cancer. International Braz J Urol: Official Journal of the Brazilian Society of Urology 33(5): 639, 2007

Prostate biopsy and radical prostatectomy Gleason score correlation in heterogenous tumors: proposal for a composite Gleason score. American Journal of Surgical Pathology 39(9): 1213-1218, 2015

Risk stratification of men with Gleason score 7 to 10 tumors by primary and secondary Gleason score: results from the SEARCH database. Urology 70(2): 277-282, 2007

Characteristics and outcome of prostate cancer patients with overall biopsy Gleason score 3 + 4 = 7 and highest Gleason score 3 + 4 = 7 or > 3 + 4 = 7. Histopathology 72(5): 760-765, 2018