+ Site Statistics
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Pattern and predictors of sick leave among users of antidepressants: a Danish retrospective register-based cohort study

Pattern and predictors of sick leave among users of antidepressants: a Danish retrospective register-based cohort study

Journal of Affective Disorders 151(3): 959-966

Depression is associated with work absenteeism, reduced productivity, and significant personal and societal economic burden. We describe patterns and determinants of sick leave among working Danish antidepressant users. Persons starting antidepressant treatment (January 1, 2004 through December 31, 2005) were identified from a representative 25% sample of the Danish population by linking Danish national registries. Inclusion criteria were age 18-64 years, being in the workforce the week prior to the first antidepressant prescription (index prescription, IP), and no antidepressant prescription in the year prior to the IP. Only sick leaves >2 weeks are centrally registered in Denmark and could be assessed. Cox regression analyses identified predictors of sick leave during the year following the IP, based on previous history of sick leave and clinical and socio-demographic baseline characteristics. In the cohort of 25,908 (59.7% women), sick leave prevalence increased from 37.5% (year prior to IP) to 45.3% (year after the IP); 30.7% were on sick leave for >8 weeks. Incidence peaked (35.5% of individuals) the week after the IP. Of persons with sick leave in the year before the IP, 62.7% were on sick leave the first week after the IP, vs 5.7% of those without previous sick leave. Predictors associated with increased risk of sick leave among those without previous sick leave were unemployment, female gender, age 25-54 years, couples with children, and vocational and higher intermediate education (including e.g. teachers and nurses). Reasons for sick leave, sick leaves of less than 14 days and the indications for antidepressant treatment were unknown. Sick leave was prevalent in persons starting new antidepressant use, often lasting >8 weeks. Previous sick leave was the strongest predictor of subsequent sick leave.

(PDF emailed within 0-6 h: $19.90)

Accession: 054895473

Download citation: RISBibTeXText

PMID: 24035488

DOI: 10.1016/j.jad.2013.08.015

Related references

Validation of sick leave measures: self-reported sick leave and sickness benefit data from a Danish national register compared to multiple workplace-registered sick leave spells in a Danish municipality. Bmc Public Health 12: 661, 2013

Night work and sick leave during pregnancy: a national register-based within-worker cohort study. Occupational and Environmental Medicine 2019, 2019

Sick Leave within 5 Years of Whiplash Trauma Predicts Recovery: A Prospective Cohort and Register-Based Study. Plos One 10(6): E0130298-E0130298, 2016

Partial sick leave associated with disability pension: propensity score approach in a register-based cohort study. Bmj Open 2(6), 2012

Sick leave before and after the age of 65 years among those in paid work in Sweden in 2000 or 2005: a register-based cohort study. Journal of International Medical Research 46(2): 564-577, 2017

Sick leave patterns among 5-year cancer survivors: a registry-based retrospective cohort study. Journal of Cancer Survivorship 6(3): 315-323, 2013

Are all-cause and diagnosis-specific sickness absence, and sick-leave duration risk indicators for suicidal behaviour? A nationwide register-based cohort study of 4.9 million inhabitants of Sweden. Occupational and Environmental Medicine 71(1): 12-20, 2014

Relationship Between Gender and the Effectiveness of Montelukast: An Italian/Danish Register-Based Retrospective Cohort Study. Frontiers in Pharmacology 9: 844, 2018

The effect of community-acquired bacteraemia on return to workforce, risk of sick leave, permanent disability pension and death: a Danish population-based cohort study. Bmj Open 4(1): E004208, 2014

The Influence of Antidepressants on the Disease Course Among Patients With Crohn's Disease and Ulcerative Colitis-A Danish Nationwide Register-Based Cohort Study. Inflammatory Bowel Diseases 2018, 2018

Occupational exposures and sick leave during pregnancy: results from a Danish cohort study. Scandinavian Journal of Work, Environment and Health 41(4): 397-406, 2016

Sick leave patterns as predictors of disability pension or long-term sick leave: a 6.75-year follow-up study in municipal eldercare workers. Bmj Open 4(2): E003941, 2014

Impact of Age, Comorbidity, and FIGO Stage on Treatment Choice and Mortality in Older Danish Patients with Gynecological Cancer: A Retrospective Register-Based Cohort Study. Drugs - Real World Outcomes 5(4): 225-235, 2018

Does return to work occur earlier after work-related sick leave episodes than after non-work-related sick leave episodes? A retrospective cohort study in Spain. Occupational and Environmental Medicine 66(1): 63-67, 2008

Effect of Chronic Kidney Diseases on Mortality among Digoxin Users Treated for Non-Valvular Atrial Fibrillation: A Nationwide Register-Based Retrospective Cohort Study. Plos One 11(7): E0160337, 2017