+ Site Statistics
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Pattern of lipid profile in patients on maintenance hemodialysis

Pattern of lipid profile in patients on maintenance hemodialysis

Saudi Journal of Kidney Diseases and Transplantation 21(3): 565-570

This hospital-based cross-sectional comparative observational study was performed to determine the pattern of lipid profile in patients on maintenance hemodialysis. The study was performed at the Department of Nephro-Urology, Liaquat University Hospital, Hyderabad, Pakistan from April 2008 to June 2008. Fifty patients with end-stage renal disease on maintenance hemodialysis (MHD) were studied. They comprised of 31 males and 19 females, the mean duration on HD was 7.58 +/- 2.05 yrs, with frequency of two to three sessions per week and each session lasting for four hours. Additionally, 25 healthy volunteers (16 male, 9 female) were also studied. After obtaining informed, written consent, general information of each patient was recorded on the proforma. After 12-hours fasting, blood samples were drawn from the arterio-venous fistula before starting dialysis. The total cholesterol, triglyceride (TG) or low density lipoprotein (LDL) levels more than 95th percentile for age and gender or high density lipoprotein (HDL) less then 35 mg/dL was defined as dyslipidemia. Descriptive and inferential statistical analysis were performed using SPSS version 16.0. The age among MHD and control groups was 47.88 +/- 13.92 and 54.56 +/- 11.16 years respectively. Serum TG and lipoprotein-a (LPa) were significantly increased (P = < 0.001 for each) while HDL-c was significantly lower (P = < 0.001) in MHD patients than in the control group. The serum cholesterol, LDL-c, VLDL-c and chylomicron levels were not significantly different in the two groups. Our study suggests that patients on MHD show abnormalities of lipid metabolism like hypertriglyceridemia, elevated lipoprotein-a and low HDL-c, which could contribute to atherosclerosis and cardiovascular disease that may increase the morbidity and mortality in these patients.

(PDF emailed within 1 workday: $29.90)

Accession: 054896115

Download citation: RISBibTeXText

PMID: 20427895

Related references

Effects of hemodialysis membrane on serum lipid profile of maintenance hemodialysis patients. Nihon Jinzo Gakkai Shi 41(1): 1-7, 1999

Can dialysis membrane improve serum lipid profile in maintenance hemodialysis patients?. Nephrology Dialysis Transplantation 12(9): A129, 1997

Ozonated autohemotherapy in patients on maintenance hemodialysis: influence on lipid profile and endothelium. Artificial Organs 28(2): 234-237, 2004

Association of serum lipid profile and arteriovenous fistula thrombosis in maintenance hemodialysis patients. Blood Purification 26(4): 322-332, 2008

Effects of carnitine and coenzyme Q10 on lipid profile and serum levels of lipoprotein(a) in maintenance hemodialysis patients on statin therapy. Iranian Journal of Kidney Diseases 5(2): 114-118, 2011

Potential Effects of Omega-3 Fatty Acids on Insulin Resistance and Lipid Profile in Maintenance Hemodialysis Patients: a Randomized Placebo-Controlled Trial. Iranian Journal of Kidney Diseases 10(5): 310-318, 2017

Effect of polyacrylonitrile pan hemodialysis on lipid metabolism in the patients undergoing maintenance hemodialysis. Journal of the American Society of Nephrology 2(3): 334, 1991

Hemodialysis membranes influence the lipid profile of patients on chronic hemodialysis. Journal of the American Society of Nephrology 11(Program and Abstract Issue): 307A, 2000

Effects of flaxseed consumption on systemic inflammation and serum lipid profile in hemodialysis patients with lipid abnormalities. Hemodialysis International. International Symposium on Home Hemodialysis 17(2): 275-281, 2014

Relationship between serum parathyroid hormone levels and lipid profile in hemodialysis patients. Evolution of lipid parameters after parathyroidectomy. Clinical Nephrology 49(5): 303-307, 1998

Vascular access profile in maintenance hemodialysis patients. Iranian Journal of Kidney Diseases 8(3): 218-224, 2015

Increased lipid peroxidation in patients on maintenance hemodialysis. Nephron 60(1): 56-59, 1992

Lipid disturbances in patients on maintenance regular hemodialysis. International Journal of Artificial Organs 26(7): 655, 2003

Behavior of antibody profile against hepatitis C virus in patients on maintenance hemodialysis. Nephron 61(3): 260-262, 1992

Association between 4-year all-cause mortality and carnitine profile in maintenance hemodialysis patients. Plos One 13(8): E0201591, 2018