+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Percutaneous left atrial appendage occlusion for patients in atrial fibrillation suboptimal for warfarin therapy: 5-year results of the PLAATO (Percutaneous Left Atrial Appendage Transcatheter Occlusion) Study



Percutaneous left atrial appendage occlusion for patients in atrial fibrillation suboptimal for warfarin therapy: 5-year results of the PLAATO (Percutaneous Left Atrial Appendage Transcatheter Occlusion) Study



Jacc. Cardiovascular Interventions 2(7): 594-600



The aim of this study was to determine 5-year clinical status for patients treated with percutaneous left atrial appendage transcatheter occlusion with the PLAATO (Percutaneous Left Atrial Appendage Transcatheter Occlusion) system. Anticoagulation reduces thromboembolism among patients with nonvalvular atrial fibrillation (AF). However, warfarin is a challenging medication due to risks of inadequate anticoagulation and bleeding. Thus, PLAATO was evaluated as a treatment strategy for nonwarfarin candidate patients with AF at high risk for stroke. Sixty-four patients with permanent or paroxysmal AF participated in this observational, multicenter prospective study. Primary end points were: new major or minor stroke, cardiac or neurological death, myocardial infarction, or requirement for cardiovascular surgery related to the procedure within 1 month of the index procedure. Patients were followed for up to 5 years. Thirty-day freedom from major adverse events rate was 98.4% (95% confidence interval: 90.89% to >99.99%). One patient, who did not receive a PLAATO implant, experienced 2 events within 30 days (cardiovascular surgery, death). Treatment success was 100% 1 month after device implantation. At 5-year follow-up, there were 7 deaths, 5 major strokes, 3 minor strokes, 1 cardiac tamponade requiring surgery, 1 probable cerebral hemorrhage/death, and 1 myocardial infarction. Only 1 event (cardiac tamponade) was adjudicated as related to the implant procedure. After up to 5 years of follow-up, the annualized stroke/transient ischemic attack (TIA) rate was 3.8%. The anticipated stroke/TIA rate (with the CHADS(2) scoring method) was 6.6%/year. The PLAATO system is safe and effective. At 5-year follow-up the annualized stroke/TIA rate in our patients was 3.8%/year, less than predicted by the CHADS(2) scoring system.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 054921800

Download citation: RISBibTeXText

PMID: 19628179

DOI: 10.1016/j.jcin.2009.05.005


Related references

PLAATO (Percutaneous Left Atrial Appendage Transcatheter Occlusion) for prevention of cardioembolic stroke in non-anticoagulation eligible atrial fibrillation patients: results from the European PLAATO study. Eurointervention 6(2): 220-226, 2010

Percutaneous left atrial appendage transcatheter occlusion (PLAATO) for stroke prevention in atrial fibrillation: 2-year outcomes. Journal of Invasive Cardiology 21(9): 446-450, 2009

Percutaneous Left Atrial Appendage Transcatheter Occlusion (PLAATO System) to Prevent Stroke in High-Risk Patients With Non-rheumatic Atrial Fibrillation: Results From the International Multi-Center Feasibility Trials. Yearbook of Medicine 2006: 365-366, 2006

Percutaneous left atrial appendage transcatheter occlusion (PLAATO system) to prevent stroke in high-risk patients with non-rheumatic atrial fibrillation: results from the international multi-center feasibility trials. Journal of the American College of Cardiology 46(1): 9-14, 2005

Percutaneous Left Atrial Appendage Transcatheter Occlusion (Plaato System) to Prevent Stroke in High-Risk Patients With Non-rheumatic Atrial Fibrillation: Results From the International Multi-Center Feasibility Trials. Yearbook of Cardiology 2006: 416-417, 2006

Percutaneous left atrial appendage transcatheter occlusion for patients with atrial fibrillation unable to take warfarin. American Heart Hospital Journal 2(2): 93-96, 2004

Left atrial structure and function after percutaneous left atrial appendage transcatheter occlusion (PLAATO): six-month echocardiographic follow-up. Journal of the American College of Cardiology 43(10): 1868-1872, 2004

Effects of percutaneous left atrial appendage transcatheter occlusion (PLAATO) on left atrial structure and function. Journal of the American College of Cardiology 45(4): 634-5; Author Reply 635, 2005

One-year echocardiographic follow-up of percutaneous left atrial appendage transcatheter occlusion in patients with atrial fibrillation. Circulation 108(17 Suppl.): IV-483-IV-484, 2003

PLAATO (Percutaneous Left Atrial Appendage Trans-catheter Occlusion) - to get off the hassles of anticoagulation in atrial fibrillation. Jpma. Journal of the Pakistan Medical Association 68(4): 677-678, 2018

Percutaneous left atrial appendage transcatheter occlusion to prevent stroke in patients with atrial fibrillation Initial results of the multicenter feasibility trial. Journal of the American College of Cardiology 41(6 Suppl. A): 79A, 2003

Percutaneous left atrial appendage transcatheter occlusion to prevent stroke in patients with atrial fibrillation Interim results of the multicenter feasibility trial. Journal of the American College of Cardiology 43(5 Suppl. A): 33A, 2004

The clinical impact of incomplete left atrial appendage closure with the Watchman Device in patients with atrial fibrillation: a PROTECT AF (Percutaneous Closure of the Left Atrial Appendage Versus Warfarin Therapy for Prevention of Stroke in Patients With Atrial Fibrillation) substudy. Journal of the American College of Cardiology 59(10): 923-929, 2012

Incomplete occlusion of the left atrial appendage with the percutaneous left atrial appendage transcatheter occlusion device is not associated with increased risk of stroke. Journal of Interventional Cardiac Electrophysiology 33(1): 69-75, 2012

Percutaneous left atrial appendage occlusion in patients with atrial fibrillation and left appendage thrombus: feasibility, safety and clinical efficacy. Eurointervention 13(13): 1595-1602, 2018