+ Site Statistics
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Physiological consequences of the TRalpha1 aporeceptor state

Physiological consequences of the TRalpha1 aporeceptor state

Heart Failure Reviews 15(2): 111-115

Many patients have been characterized harboring a mutation in thyroid hormone receptor (TR) beta. Surprisingly none has yet been identified carrying a mutation in TRalpha1. To facilitate the identification of such patients, several animal models with a mutant TRalpha1 have been generated. While some phenotypic characteristics, such as an adult euthyroidism, are similar in the mutant mice, other aspects such as metabolism are quite variable. This review summarizes the most important consequences of a mutation in TRalpha1 in mice focusing on the TRalpha1-R384C mutation, and projects the insights from the animal models to a putative phenotype of patients with a mutated TRalpha1.

(PDF emailed within 0-6 h: $19.90)

Accession: 055001574

Download citation: RISBibTeXText

PMID: 19009345

DOI: 10.1007/s10741-008-9119-5

Related references

Clinical Phenotype of a New Type of Thyroid Hormone Resistance Caused by a Mutation of the TRalpha1 Receptor Consequences of LT4 Treatment. 2013

Clinical phenotype of a new type of thyroid hormone resistance caused by a mutation of the TRalpha1 receptor; consequences of LT4 treatment. 2013

The instrumental effects of emotional behavior consequences for the physiological state. Hamilton, V , G H Bower And N H Frijda (Ed ) Nato Asi (Advanced Science Institutes) Series, Series D: Behavioral And Social Sciences, Vol 44 Cognitive Perspectives on Emotion And Motivation; Workshop, Tuscany, Italy, June 21-27, 1987 Xiii+453p Kluwer Academic Publishers: Dordrecht, Netherlands; Boston, Massachusetts, Usa Illus 221-238, 1988

Influence of vigilance state on physiological consequences of seizures and seizure-induced death in mice. Journal of Neurophysiology 115(5): 2286-2293, 2016

Physiological Employment Standards III: physiological challenges and consequences encountered during international military deployments. European Journal of Applied Physiology 113(11): 2655-2672, 2014

HSP90 Mutants affect the stability and ligand binding activity of glucocorticoid aporeceptor complexes. Molecular Biology of the Cell 5(SUPPL ): 18A, 1994

Hsp90 mutants disrupt glucocorticoid receptor ligand binding and destabilize aporeceptor complexes. Journal of Biological Chemistry 270(49): 29433-8, 1995

Nutrition physiological consequences from work physiological findings. Zentralblatt fuer Arbeitsmedizin und Arbeitsschutz 21(8): 268, 1971

Thyroid hormone aporeceptor represses T3-inducible promoters and blocks activity of the retinoic acid receptor. New Biologist 1(3): 329-336, 1989

Does the new antiarrythmic drug dronedarone inhibit the binding of T3 to the TRalpha1 and TRbeta1 like amiodarone?. Endocrine Journal 47(Suppl August): 166, August, 2000

Cooperation between the thyroid hormone receptor TRalpha1 and the WNT pathway in the induction of intestinal tumorigenesis. Gastroenterology 138(5): 1863-1874, 2010

Normal timing of oligodendrocyte development depends on thyroid hormone receptor alpha 1 (TRalpha1). EMBO (European Molecular Biology Organization) Journal 21(23): 6452-6460, 2002

A novel functional co-operation between MyoD, MEF2 and TRalpha1 is sufficient for the induction of GLUT4 gene transcription. Journal of Molecular Biology 314(2): 195-204, 2001