+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Physiological effects of microgravity on bone cells



Physiological effects of microgravity on bone cells



Calcified Tissue International 94(6): 569-579



Life on Earth developed under the influence of normal gravity (1g). With evidence from previous studies, scientists have suggested that normal physiological processes, such as the functional integrity of muscles and bone mass, can be affected by microgravity during spaceflight. During the life span, bone not only develops as a structure designed specifically for mechanical tasks but also adapts for efficiency. The lack of weight-bearing forces makes microgravity an ideal physical stimulus to evaluate bone cell responses. One of the most serious problems induced by long-term weightlessness is bone mineral loss. Results from in vitro studies that entailed the use of bone cells in spaceflights showed modification in cell attachment structures and cytoskeletal reorganization, which may be involved in bone loss. Humans exposed to microgravity conditions experience various physiological changes, including loss of bone mass, muscle deterioration, and immunodeficiency. In vitro models can be used to extract valuable information about changes in mechanical stress to ultimately identify the different pathways of mechanotransduction in bone cells. Despite many in vivo and in vitro studies under both real microgravity and simulated conditions, the mechanism of bone loss is still not well defined. The objective of this review is to summarize the recent research on bone cells under microgravity conditions based on advances in the field.

(PDF emailed within 0-6 h: $19.90)

Accession: 055001764

Download citation: RISBibTeXText

PMID: 24687524

DOI: 10.1007/s00223-014-9851-x


Related references

Influence of bisphosphonates on calcium metabolism and bone tissue during simulation of the physiological effects of microgravity. Journal of Gravitational Physiology 5(1): P69-P70, 2001

Microgravity and bone: Effects of modeled microgravity on osteoblast. 2007

The effects of simulated microgravity on the pattern of gene expression in human bone marrow mesenchymal stem cells under osteogenic differentiation. Fiziologiia Cheloveka 39(5): 105-111, 2015

Experimental role of in vitro bone cell culture in the study of the effects of microgravity on bone tissue. Travaux Scientifiques des Chercheurs du Service de Sante des Armees (11): 159-160, 1990

Bone cell survival in microgravity: evidence that modeled microgravity increases osteoblast sensitivity to apoptogens. Annals of the New York Academy of Sciences 1027: 64-73, 2005

Physiological effects of microgravity on osteoblast morphology and cell biology. Advances in Space Biology and Medicine 8: 129-157, 2003

The impact of simulated and real microgravity on bone cells and mesenchymal stem cells. Biomed Research International 2014: 928507-928507, 2015

Physiological effects of microgravity as risk factors of diseases during space flight. Patologicheskaia Fiziologiia i Eksperimental'naia Terapiia: 70-76, 2012

Can inhibition of standing on hindlimbs for 1 month produce the physiological effects of microgravity?. Japanese Journal of Physiology 45(SUPPL 1): S263, 1995

Microgravity and drug effects on bone. Journal of Musculoskeletal & Neuronal Interactions 6(4): 322-323, 2006

Hormonal regulation of metabolism in the human body in microgravity and during simulation of its physiological effects. Aviakosmicheskaia i Ekologicheskaia Meditsina 37(2): 32-41, 2003

Effects of microgravity on bone and calcium homeostasis. Advances in Space Research 21(8-9): 1049-1058, 2001

Effects of microgravity on vestibular ontogeny: direct physiological and anatomical measurements following space flight (STS-29). Acta Veterinaria 62(6 Suppl): S35-S42, 1993

Interactions of cells in zones of bone resorption under microgravity and hypokinesia. Journal of Gravitational Physiology 11(2): P147-P151, 2005

Effects of clinostat-microgravity on bone and calcium metabolism in rats. Journal of Gravitational Physiology 7(2): P123-P124, 2003