Section 56
Chapter 55,022

Plasma viral loads during early HIV-1 infection are similar in subtype C- and non-subtype C-infected African seroconverters

Campbell, M.S.; Kahle, E.M.; Celum, C.; Lingappa, J.R.; Kapiga, S.; Mujugira, A.; Mugo, N.R.; Fife, K.H.; Mullins, J.I.; Baeten, J.M.; Celum, C.; Wald, A.; Lingappa, J.; Baeten, J.M.; Campbell, M.S.; Corey, L.; Coombs, R.W.; Hughes, J.P.; Magaret, A.; McElrath, M.Juliana.; Morrow, R.; Mullins, J.I.; Coetzee, D.; Fife, K.; Were, E.; Essex, M.; Makhema, J.; Katabira, E.; Ronald, A.; Allen, S.; Kayitenkore, K.; Karita, E.; Bukusi, E.; Cohen, C.; Allen, S.; Kanweka, W.; Allen, S.; Vwalika, B.; Kapig

Journal of Infectious Diseases 207(7): 1166-1170


ISSN/ISBN: 0022-1899
PMID: 23315322
DOI: 10.1093/infdis/jit015
Accession: 055021955

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Recent data suggest that infection with human immunodeficiency virus type 1 (HIV-1) subtype C results in prolonged high-level viremia (>5 log10 copies/mL) during early infection. We examined the relationship between HIV-1 subtype and plasma viremia among 153 African seroconverters. Mean setpoint viral loads were similar for C and non-C subtypes: 4.36 vs 4.42 log10 copies/mL (P = .61). The proportion of subtype C–infected participants with viral loads >5 log10 copies/mL was not greater than the proportion for those with non-C infection. Our data do not support the hypothesis that higher early viral load accounts for the rapid spread of HIV-1 subtype C in southern Africa.

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