Home
  >  
Section 56
  >  
Chapter 55,022

Plasma viral loads during early HIV-1 infection are similar in subtype C- and non-subtype C-infected African seroconverters

Campbell, M.S.; Kahle, E.M.; Celum, C.; Lingappa, J.R.; Kapiga, S.; Mujugira, A.; Mugo, N.R.; Fife, K.H.; Mullins, J.I.; Baeten, J.M.; Celum, C.; Wald, A.; Lingappa, J.; Baeten, J.M.; Campbell, M.S.; Corey, L.; Coombs, R.W.; Hughes, J.P.; Magaret, A.; McElrath, M.Juliana.; Morrow, R.; Mullins, J.I.; Coetzee, D.; Fife, K.; Were, E.; Essex, M.; Makhema, J.; Katabira, E.; Ronald, A.; Allen, S.; Kayitenkore, K.; Karita, E.; Bukusi, E.; Cohen, C.; Allen, S.; Kanweka, W.; Allen, S.; Vwalika, B.; Kapig

Journal of Infectious Diseases 207(7): 1166-1170

2013

ISSN/ISBN: 0022-1899
PMID: 23315322
DOI: 10.1093/infdis/jit015
Accession: 055021955
Download citation:  
Text
  |  
BibTeX
  |  
RIS
Recent data suggest that infection with human immunodeficiency virus type 1 (HIV-1) subtype C results in prolonged high-level viremia (>5 log10 copies/mL) during early infection. We examined the relationship between HIV-1 subtype and plasma viremia among 153 African seroconverters. Mean setpoint viral loads were similar for C and non-C subtypes: 4.36 vs 4.42 log10 copies/mL (P = .61). The proportion of subtype C–infected participants with viral loads >5 log10 copies/mL was not greater than the proportion for those with non-C infection. Our data do not support the hypothesis that higher early viral load accounts for the rapid spread of HIV-1 subtype C in southern Africa.

PDF emailed within 0-6 h: $19.90




Related References

Campbell, M. S.; Kahle, E. M.; Celum, C.; Lingappa, J. R.; Kapiga, S.; Mujugira, A.; Mugo, N. R.; Fife, K. H.; Mullins, J. I.; Baeten, J. M.; Celum, C.; Wald, A.; Lingappa, J.; Baeten, J. M.; Campbell, M. S.; Corey, L.; Coombs, R. W.; Hughes, J. P.; Magaret, A.; McElrath, M. J.; Morrow, R.; Mullins, J. I.; Coetzee, D.; Fife, K.; Were, E.; Essex, M.; Makhema, J.; Katabira, E.; Ronald, A.; Allen, S.; Kayitenkore, K.; Karita, E.; Bukusi, E.; Cohen, C.; Allen, S.; Kanweka, W.; Allen, S.; Vwalika, B. 2013: Plasma Viral Loads During Early HIV-1 Infection Are Similar in Subtype C- and Non-Subtype C-Infected African Seroconverters The Journal of Infectious Diseases 207(7): 1166-1170
Baeten, J.M.; Chohan, B.; Lavreys, L.; Chohan, V.; McClelland, R.S.; Certain, L.; Mandaliya, K.; Jaoko, W.; Overbaugh, J. 2007: HIV-1 subtype D infection is associated with faster disease progression than subtype a in spite of similar plasma HIV-1 loads Journal of Infectious Diseases 195(8): 1177-1180
Paraskevis, D.; Touloumi, G.; Bakoyannis, G.; Paparizos, V.; Lazanas, M.; Gargalianos, P.; Chryssos, G.; Antoniadou, A.; Psichogiou, M.; Panos, G.; Katsarou, O.; Sambatakou, H.; Kordossis, T.; Hatzakis, A.; Antoniadou, A.; Chrysos, G.; Daikos, G.; Gargalianos-Kakolyris, P.; Gogos, H.A.; Katsarou, O.; Kordossis, T.; Lazanas, M.; Nikolaidis, P.; Panos, G.; Paparizos, V.; Paraskevis, D.; Sambatakou, H.; Skoutelis, A.; Touloumi, G.; Touloumi, G.; Pantazis, N.; Bakoyannis, G.; Vourli, G.; Gioukari, V.; Antoniadou, A.; Papadopoulos, A.; Petrikkos, G.; Chrysos, G.; Paraskeva, D.; Hatziastros, P.; Daikos, G.; Psichogiou, M.; Gargalianos-Kakolyris, P.; Xylomenos, G.; Gogos, H.A.; Maragos, M.N.; Panos, G.; Katsarou, O.; Kouramba, A.; Ioannidou, P.; K 2013: Effect of HIV type 1 subtype on virological and immunological response to combination antiretroviral therapy: evidence for a more rapid viral suppression for subtype a than subtype B-infected Greek individuals Aids Research and Human Retroviruses 29(3): 461-469
Gottesman, B.-S.; Grosman, Z.; Lorber, M.; Levi, I.; Shitrit, P.; Mileguir, F.; Gottesman, G.; Chowers, M.Y. 2004: Measurement of HIV RNA in patients infected by subtype C by assays optimized for subtype B results in an underestimation of the viral load Journal of Medical Virology 73(2): 167-171
Damond, F.; Gueudin, M.; Pueyo, S.; Farfara, I.; Robertson, D.L.; Descamps, D.; Chène, G.èv.; Matheron, S.; Campa, P.; Brun-Vézinet, F.ço.; Simon, F.ço. 2002: Plasma RNA viral load in human immunodeficiency virus type 2 subtype a and subtype B infections Journal of Clinical Microbiology 40(10): 3654-3659
Kapaata, A.; Balinda, S.N.; Hare, J.; Leonova, O.; Kikaire, B.; Egesa, M.; Lubyayi, L.; Macharia, G.N.; Kamali, A.; Gilmour, J.; Bagaya, B.; Salazar-Gonzalez, J.F.; Kaleebu, P. 2022: Infection with HIV-1 subtype D among acutely infected Ugandans is associated with higher median concentration of cytokines compared to subtype a Ijid Regions 3: 89-95
Komoto, S.; Kinomoto, M.; Ibrahim, M.S.; Zhong, Q.; Auwanit, W.; Ayuthaya, P.I.; Otake, T.; Mori, H.; Oishi, I.; Kurosu, T.; Takahashi, H.; Mukai, T.; Ikuta, K. 2001: Low or no antibody responses to human immunodeficiency virus type 1 Nef in infected carriers with subtype E, in contrast to subtype B that showed antibodies preferentially recognizing subtype-specific Nef epitopes Vaccine 19(20-22): 3019-3032
Jeong, M.A.; Jeong, Y.J.; Kim, K.I. 2022: Virulence difference between red sea bream iridovirus mixed subtype I/Ii and subtype Ii and the expression of viral and apoptosis-related genes in infected rock bream (Oplegnathus fasciatus) Fish and Shellfish Immunology 127: 195-202
Kalpana, A.; Srikanth, T.; Abhay, J.; Sushama, J.; Swarali, K.; Ramesh, P. 2004: Gp120 sequences from HIV type 1 subtype C early seroconverters in India Aids Research and Human Retroviruses 20(8): 889-894
De la Rosa, R.; Leal, M.; Pineda, J.A.; Dietrich, U.; Delgado, J.; Macías, J.; Rubio, A.; Sánchez-Quijano, A.; Lissen, E. 2001: Low levels of HIV-1 plasma viral load in patients infected with HIV-1 subtype b and advanced immunosuppression Journal of Infection 42(1): 4-7
Huang, S.-W.; Wang, S.-F.; Lin, Y.-T.; Yen, C.-H.; Lee, C.-H.; Wong, W.-W.; Tsai, H.-C.; Yang, C.-J.; Hu, B.-S.; Lin, Y.-H.; Wang, C.-T.; Wang, J.-J.; Hu, Z.; Kuritzkes, D.R.; Chen, Y.-H.; Chen, Y.-M.A. 2014: Patients infected with CRF07_BC have significantly lower viral loads than patients with HIV-1 subtype B: mechanism and impact on disease progression Plos one 9(12): E114441
Ng, O.T.; Lin, L.; Laeyendecker, O.; Quinn, T.C.; Sun, Y.J.; Lee, C.C.; Leo, Y.S. 2011: Increased rate of CD4+ T-cell decline and faster time to antiretroviral therapy in HIV-1 subtype CRF01_AE infected seroconverters in Singapore Plos one 6(1): E15738
Lole, K.S.; Bollinger, R.C.; Paranjape, R.S.; Gadkari, D.; Kulkarni, S.S.; Novak, N.G.; Ingersoll, R.; Sheppard, H.W.; Ray, S.C. 1999: Full-length human immunodeficiency virus type 1 genomes from subtype C-infected seroconverters in India, with evidence of intersubtype recombination Journal of Virology 73(1): 152-160
Price, M.A.; Rida, W.; Kilembe, W.; Karita, E.; Inambao, M.; Ruzagira, E.; Kamali, A.; Sanders, E.J.; Anzala, O.; Hunter, E.; Allen, S.; Edward, V.A.; Wall, K.M.; Tang, J.; Fast, P.E.; Kaleebu, P.; Lakhi, S.; Mutua, G.; Bekker, L.Gail.; Abu-Baker, G.; Tichacek, A.; Chetty, P.; Latka, M.H.; Maenetje, P.; Makkan, H.; Kibengo, F.; Priddy, F.; Gilmour, J. 2019: Control of the HIV-1 Load Varies by Viral Subtype in a Large Cohort of African Adults With Incident HIV-1 Infection Journal of Infectious Diseases 220(3): 432-441
Ming, D.I.N.G.; Tarwater, P.; Gupta, P.; Rodriguez, M.; Chatterjee, R.; Ratner, D.; Yamamura, Y.; Roy, P.; Mellors, J.; Neogi, D.; Yue, C.H.E.N. 2009: Estimation of the Predictive Role of Plasma Viral Load on CD4 Decline in HIV-1 Subtype C-Infected Subjects in India Journal of Acquired Immune Deficiency Syndromes (1999) 50(2): 119-125
Ding, M.; Tarwater, P.; Rodriguez, M.; Chatterjee, R.; Ratner, D.; Yamamura, Y.; Roy, P.; Mellors, J.; Neogi, D.; Chen, Y.; Gupta, P. 2009: Estimation of the predictive role of plasma viral load on CD4 decline in HIV-1 subtype C-infected subjects in India Journal of Acquired Immune Deficiency Syndromes 50(2): 119-125
Basu, D; Sharkey, T; Kilembe, W; Allen, S; Hunter, E 2014: A New Cost-effective Viral RNA PCR-based Diagnostic for Detection of Early Subtype C HIV-1 Infection Aids Research and Human Retroviruses 30(S1): A227-A228
Ndlovu, B G.; Chung, A; Maroa, J; Walker, B D.; Alter, G; Ndung'u, T 2014: Gp41 and p24 IgG Binding Antibody Titers Are Associated with HIV-1 Viral Control during Early HIV-1 Subtype C Infection Aids Research and Human Retroviruses 30(S1): A248-A248
Grobler, J.; Gray, C.M.; Rademeyer, C.; Seoighe, C.; Ramjee, G.; Karim, S.Abdool.; Morris, L.; Williamson, C. 2004: Incidence of HIV-1 dual infection and its association with increased viral load set point in a cohort of HIV-1 subtype C-infected female sex workers Journal of Infectious Diseases 190(7): 1355-1359
Bochner, A.F.; Secor, W.E.; Baeten, J.M.; van Dam, G.J.; Szpiro, A.A.; Njenga, S.M.; Corstjens, P.L.A.M.; Mackelprang, R.D.; Mugo, N.R.; Overbaugh, J.; Celum, C.; Mujugira, A.; McClelland, R.S.; Barnabas, R.V. 2019: Schistosomiasis was not associated with higher HIV-1 plasma or genital set point viral loads among HIV seroconverters from four cohort studies Plos Neglected Tropical Diseases 13(11): E0007886