+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Polymorphisms in apoptosis-related genes and survival of patients with early-stage non-small-cell lung cancer



Polymorphisms in apoptosis-related genes and survival of patients with early-stage non-small-cell lung cancer



Annals of Surgical Oncology 17(10): 2608-2618



This study was conducted to determine the association between single-nucleotide polymorphisms (SNPs) in apoptosis-related genes and survival outcomes of patients with early-stage non-small-cell lung cancer (NSCLC). Three hundred ten consecutive patients with surgically resected NSCLC were enrolled. Twenty-five SNPs in 17 apoptosis-related genes were genotyped by a sequenome mass spectrometry-based genotyping assay. The genotype associations with overall survival (OS) and disease-free survival (DFS) were analyzed. Three SNPs (TNFRSF10B rs1047266, TNFRSF1A rs4149570, and PPP1R13L rs1005165) were significantly associated with survival outcomes on multivariate analysis. When the three SNPs were combined, OS and DFS were decreased as the number of bad genotypes increased (P (trend) for OS and DFS = 7 × 10(-5) and 1 × 10(-4), respectively). Patients with one bad genotype, and patients with two or three bad genotypes had significantly worse OS and DFS compared with those with no bad genotypes [adjusted hazard ratio (aHR) for OS = 2.27, 95% confidence interval (CI) = 1.22-4.21, P = 0.01, aHR for DFS = 1.74, 95% CI = 1.08-2.81, P = 0.02; aHR for OS = 4.11, 95% CI = 2.03-8.29, P = 8 × 10(-5); and aHR for DFS = 2.89, 95% CI = 1.64-5.11, P = 3 × 10(-4), respectively]. Three SNPs in apoptosis-related genes were identified as possible prognostic markers of survival in patients with early-stage NSCLC. The SNPs, and particularly their combined genotypes, can be used to identify patients at high risk for poor disease outcome.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 055047114

Download citation: RISBibTeXText

PMID: 20422457

DOI: 10.1245/s10434-010-1082-4


Related references

Polymorphisms in the CASPASE genes and survival in patients with early-stage non-small-cell lung cancer. Journal of Clinical Oncology 27(34): 5823-5829, 2009

Polymorphisms in mitotic checkpoint-related genes can influence survival outcomes of early-stage non-small cell lung cancer. Oncotarget 8(37): 61777-61785, 2017

Polymorphisms in the FAS and FASL genes and survival of early stage non-small cell lung cancer. Clinical Cancer Research 15(5): 1794-1800, 2009

Polymorphisms of vitamin D receptor and survival in early-stage non-small cell lung cancer patients. Cancer Epidemiology Biomarkers and Prevention 15(11): 2239-2245, 2006

Comprehensive analysis of DNA repair gene polymorphisms and survival in patients with early stage non-small-cell lung cancer. Cancer Science 101(11): 2436-2442, 2010

MicroRNA-related polymorphisms in apoptosis pathway genes are predictive of clinical outcome in patients with limited disease small cell lung cancer. Oncotarget 7(16): 22632-8, 2016

Polymorphisms in DNA repair and apoptosis-related genes and clinical outcomes of patients with non-small cell lung cancer treated with first-line paclitaxel-cisplatin chemotherapy. Lung Cancer 82(2): 330-339, 2013

VEGF polymorphisms and survival in early-stage non-small-cell lung cancer. Journal of Clinical Oncology 26(6): 856-862, 2008

AKT1 polymorphisms and survival of early stage non-small cell lung cancer. Journal of Surgical Oncology 105(2): 167-174, 2012

Polymorphisms in apoptosis-related genes and TP53 mutations in non-small cell lung cancer. Journal of Korean Medical Science 26(11): 1527-1530, 2011

Expression analysis of angiogenesis-related genes in Bulgarian patients with early-stage non-small cell lung cancer. Tumori 97(1): 86-94, 2011

Polymorphisms in ERCC2 and overall survival (OS) in early stage non-small cell lung cancer (NSCLC). Journal of Clinical Oncology 23(16_Suppl): 9524-9524, 2016

Association between polymorphisms in microRNA target sites and survival in early-stage non-small cell lung cancer. Thoracic Cancer 8(6): 682-686, 2017

Prediction of survival and cancer recurrence using F-18 FDG PET/CT in patients with surgically resected early stage (Stage I and II) non-small cell lung cancer. Neoplasma 58(3): 245-250, 2011

Functional polymorphisms in PD-L1 gene are associated with the prognosis of patients with early stage non-small cell lung cancer. Gene 599: 28-35, 2017