+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Positivity rates and performances of immunochemical faecal occult blood tests at different cut-off levels within a colorectal cancer screening programme

Positivity rates and performances of immunochemical faecal occult blood tests at different cut-off levels within a colorectal cancer screening programme

Digestive and Liver Disease 44(8): 700-704

Immunochemical faecal occult blood tests have greater sensitivity for colorectal cancer screening than guaiac-based tests; however the number of positive tests required is still under discussion. A direct comparison of Hemoccult II with two immunochemical quantitative tests (OC-Sensor and FOB-Gold) using a 2-sample strategy was performed in over 30,000 patients undergoing colorectal cancer screening in France. Positivity ratio between immunochemical tests and Hemoccult II varied between 2.2 (OC-Sensor) and 2.4 (FOB-Gold) for the lowest cut-off value and 1.5-1.4 for the highest cut-off value. The positive predictive value for colorectal cancer was similar for immunochemical tests and Hemoccult II, and significantly higher for immunochemical tests for advanced adenomas. The detection rate of both colorectal cancer and advanced adenomas was higher with immunochemical tests than with Hemoccult II. With the 2-sample strategy and the lowest cut-off value the detection rate of colorectal cancer almost doubled and for advanced adenomas quadrupled. For colorectal cancer screening with immunochemical faecal occult blood tests, an acceptable strategy would be 2-day sampling with at least one positive test at a cut-off between 150 and 200 ng/mL (OC-Sensor) and 176 and 234 ng/mL (FOB-Gold). Data on the ease of test interpretation and cost-effectiveness now necessary to make definitive choices.

Please choose payment method:

(PDF emailed within 0-6 h: $19.90)

Accession: 055061173

Download citation: RISBibTeXText

PMID: 22542582

DOI: 10.1016/j.dld.2012.03.015

Related references

Faecal immunochemical tests versus guaiac faecal occult blood tests: what clinicians and colorectal cancer screening programme organisers need to know. Gut 64(8): 1327-1337, 2015

Implementation of Failure Mode and Effects Analysis to the specimens flow in a population-based colorectal cancer screening programme using immunochemical faecal occult blood tests: a quality improvement project in the Milan colorectal cancer screening programme. Bmj Open Quality 7(1): E000299, 2018

Immunochemical vs guaiac faecal occult blood tests in a population-based screening programme for colorectal cancer. British Journal of Cancer 74(1): 141-144, 1996

M1013 a Cost-Effectiveness Analysis in Colorectal Cancer Screening Comparing Immunochemical Faecal Occult Blood Tests with Guaiac Faecal Occult Blood Tests and No Screening. Gastroenterology 136(5): A-331, 2009

Cost-effectiveness of the faecal immunochemical test at a range of positivity thresholds compared with the guaiac faecal occult blood test in the NHS Bowel Cancer Screening Programme in England. Bmj Open 7(10): E017186, 2017

Screening for colorectal cancer with immunochemical faecal occult blood tests. Digestive and Liver Disease 44(12): 967-973, 2012

Guaiac and immunochemical tests for faecal occult blood in colorectal cancer screening. British Journal of Cancer 65(6): 942-944, 1992

Performance of immunochemical faecal occult blood test in colorectal cancer screening in average-risk population according to positivity threshold and number of samples. International Journal of Cancer 125(5): 1127-1133, 2009

Immunochemical faecal occult blood tests for colorectal cancer screening: no time to lose. Digestive and Liver Disease 46(1): 30-31, 2014

Screening for colorectal cancer by faecal occult blood test: comparison of immunochemical tests. Journal of Medical Screening 7(1): 35-37, 2000

Comparison between a guaiac and three immunochemical faecal occult blood tests in screening for colorectal cancer. European Journal of Cancer 48(16): 2969-2976, 2012

Performance of two faecal immunochemical tests for the detection of advanced neoplasia at different positivity thresholds: a cross-sectional study of the Dutch national colorectal cancer screening programme. Lancet. Gastroenterology and Hepatology 4(2): 111-118, 2019

Screening for colorectal cancer using an immunochemical test for faecal occult blood: results of the first 2 years of a South Australian programme. Australian and New Zealand Journal of Surgery 64(7): 464-469, 1994

Different seasons with decreased performance of immunochemical faecal occult blood tests in colorectal cancer screening. Gut 60(9): 1303-4; Author Reply 1304, 2011

An analysis of the duplicate testing strategy of an Irish immunochemical faecal occult blood test colorectal cancer screening programme. Colorectal Disease 15(9): E512-E521, 2013