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Posterior reversible encephalopathy syndrome in pediatric hematologic-oncologic disease: literature review and case presentation



Posterior reversible encephalopathy syndrome in pediatric hematologic-oncologic disease: literature review and case presentation



Iranian Journal of Child Neurology 8(2): 1-10



Posterior reversible encephalopathy syndrome (PRES) is a cliniconeuroradiological disease entity, which is represented by characteristic magnetic resonance imaging (MRI) findings of subcortical/cortical hyperintensity in T2-weighted sequences. It is more often seen in parietaloccipital lobes, and is accompanied by clinical neurological changes. PRES is a rare central nervous system (CNS) complication in patients with childhood hematologic-oncologic disese and shows very different neurological symptoms between patients, ranging from numbness of extremities to generalized seizure. In this article, we will review PRES presentation in hematologic-oncologic patients. Then, we will present our patient, a 7-year-old boy with Evans syndrome on treatment with cyclosporine, mycophenolate mofetil (MMF) and prednisone, with seizure episodes and MRI finding in favour of PRES.

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Accession: 055070481

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PMID: 24949044


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