+ Translate
+ Most Popular
Cunninghamia lanceolata plantations in China
Mammalian lairs in paleo ecological studies and palynology
Studies on technological possibilities in utilization of anhydrous milk fat for production of recombined butter-like products
Should right-sided fibroelastomas be operated upon?
Large esophageal lipoma
Apoptosis in the mammalian thymus during normal histogenesis and under various in vitro and in vivo experimental conditions
Poissons characoides nouveaux ou non signales de l'Ilha do Bananal, Bresil
Desensitizing efficacy of Colgate Sensitive Maximum Strength and Fresh Mint Sensodyne dentifrices
Administration of fluid by subcutaneous infusion: revival of a forgotten method
Tundra mosquito control - an impossible dream?
Schizophrenia for primary care providers: how to contribute to the care of a vulnerable patient population
Geochemical pattern analysis; method of describing the Southeastern limestone regional aquifer system
Incidence of low birth weights in a hospital of Mexico City
Graded management intensity of grassland systems for enhancing floristic diversity
Microbiology and biochemistry of cheese and fermented milk
The ember tetra: a new pygmy characid tetra from the Rio das Mortes, Brazil, Hyphessobrycon amandae sp. n. (Pisces, Characoidei)
Risk factors of contrast-induced nephropathy in patients after coronary artery intervention
Renovation of onsite domestic wastewater in a poorly drained soil
Observations of the propagation velocity and formation mechanism of burst fractures caused by gunshot
Systolic blood pressure in a population of infants in the first year of life: the Brompton study
Haematological studies in rats fed with metanil yellow
Studies on pasteurellosis. I. A new species of Pasteurella encountered in chronic fowl cholera
Dormancy breaking and germination of Acacia salicina Lindl. seeds
therapy of lupus nephritis. a two-year prospective study

Postsynaptic deregulation in GAP-43 heterozygous mouse barrel cortex

Postsynaptic deregulation in GAP-43 heterozygous mouse barrel cortex

Cerebral Cortex 20(7): 1696-1707

ISSN/ISBN: 1047-3211

PMID: 19915093

DOI: 10.1093/cercor/bhp231

Formation of whisker-related barrels in primary somatosensory cortex (S1) requires communication between presynaptic thalamocortical afferents (TCAs) and postsynaptic cortical neurons. GAP-43 is crucially involved in targeting TCAs to postsynaptic S1 neurons but its influence on the interactions between these 2 elements has not been explored. Here, we tested the hypothesis that reduced early expression of presynaptic GAP-43 (GAP-43 heterozygous [HZ] mice) alters postsynaptic differentiation of barrel cells. We found a transient increase in cytochrome oxidase staining between P6 and P14 in HZ animals, indicative of increased metabolic activity in barrel cortex during this time. Golgi impregnation and microtubule-associated protein 2 immunohistochemistry showed anomalous dendritic patterning in GAP-43 HZ cortex at P5, with altered dendritic length and branching and abnormal retention of dendrites that extend into developing septa. This deficiency was no longer apparent at P7, suggesting partial recovery of dendritic pruning processes. Finally, we showed early defects in synaptogenesis from P4 to P5 with increased colocalization of NR1 and GluR1 staining in HZ mice. By P7, this colocalization had normalized to wild type levels. Taken together, our findings suggest abnormal postsynaptic differentiation in GAP-43 HZ cortex during early barrel development, followed by adaptive compensation and partial phenotypic rescue.

Please choose payment method:

(PDF emailed within 0-6 h: $19.90)

Accession: 055076578

Download citation: RISBibTeXText

Related references

Identified neurons in mouse posteromedial barrel subfield cortex which are postsynaptic to thalamo cortical axon terminals. Anatomical Record 190(2): 582-583, 1978

Direct 3D Analyses Reveal Barrel-Specific Vascular Distribution and Cross-Barrel Branching in the Mouse Barrel Cortex. Cerebral Cortex 26(1): 23-31, 2016

Postsynaptic activity is required for experience-dependent potentiation in rat barrel cortex. Journal of Physiology (Cambridge) 515P: 51P-52P, 1999

Distribution of GABAergic elements postsynaptic to ventroposteromedial thalamic projections in layer IV of rat barrel cortex. European Journal of Neuroscience 8(11): 2273-2285, 1996

NMDA receptor-dependent pattern transfer from afferents to postsynaptic cells and dendritic differentiation in the barrel cortex. Molecular and Cellular Neurosciences 21(3): 477-492, 2002

Blockade of postsynaptic activity prevents the formation of whisker barrels in embryonic occipital cortex transplanted into the barrel field. Society for Neuroscience Abstracts 24(1-2): 59, 1998

Enhancement of postsynaptic GABAA and extrasynaptic NMDA receptor-mediated responses in the barrel cortex of Mecp2-null mice. Journal of Neurophysiology 115(3): 1298-1306, 2016

Chronic suppression of activity in barrel field cortex downregulates sensory responses in contralateral barrel field cortex. Journal of Neurophysiology 94(5): 3342-3356, 2005

Vascular patterns in mouse and rat barrel cortex. Society for Neuroscience Abstracts 14(1): 224, 1988

Axonal projections in mouse barrel cortex. Society for Neuroscience Abstracts 15(1): 312, 1989

Functional organization in mouse barrel cortex. Brain Research 165(2): 327-332, 1979

Local connections in mouse barrel cortex. Society for Neuroscience Abstracts 14(1): 222, 1988

The functional microarchitecture of the mouse barrel cortex. Plos Biology 5(7): E189, 2007

Synaptic zinc in the developing barrel cortex of the mouse. Society for Neuroscience Abstracts 22(1-3): 106, 1996

Intrinsic inhibitory pathways in mouse barrel cortex. Neuroreport 7(14): 2363-2368, 1996