+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Pre-induction cervical ripening with 25 microg and 50 microg vaginal misoprostol in 181 nulliparous parturients



Pre-induction cervical ripening with 25 microg and 50 microg vaginal misoprostol in 181 nulliparous parturients



Journal of Maternal-Fetal and Neonatal Medicine 22(3): 265-268



To evaluate the effect of intravaginally misoprostol at start dosages of 25 microg and 50 microg when used for pre-induction cervical ripening among nulliparous parturients. Our observational study involves all cases of partus induction consecutively registered in a Norwegian hospital between September 2002 and August 2006, with the following inclusion criteria: nulliparous, singleton pregnancies >or=37 weeks, an unfavourable cervix (Bishop score 2499 g, received misoprostol vaginally every 6 h upto four times. Seventy-six women started with 25 microg (25 microg-group) and 105 started with 50 microg (50 microg-group). All continued with 25 microg. Primary outcome was vaginal delivery within 48 h after the first misoprostol dose. Secondary outcome was caesarean section performed within 96. Vaginal delivery within 48 h after the initial dose occurred more often in the 25 microg-group than in the 50 microg-group (75 vs. 58%, p = 0.018). The rate of caesarean section was lower in the 25 microg-group than in the 50 microg-group (19 vs. 33%, p = 0.043). These differences remained significant after adjusting for confounders. Our findings support the notion that the dose of 25 microg misoprostol is as at least as efficient as 50 microg in nulliparous parturients.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 055092251

Download citation: RISBibTeXText

PMID: 19330712

DOI: 10.1080/14767050902763142


Related references

Cervical ripening and labor induction with 25 microg vs. 50 microg of intravaginal misoprostol. International Journal of Gynaecology and Obstetrics: the Official Organ of the International Federation of Gynaecology and Obstetrics 90(3): 234-235, 2005

Oral misoprostol (100 microg) versus vaginal misoprostol (25 microg) in term labor induction: a randomized comparison. Acta Obstetricia et Gynecologica Scandinavica 82(12): 1103-1106, 2003

A comparison between single dose of 50 microg oral misoprostol and 25 microg vaginal misoprostol for labor induction. Journal of the Medical Association of Thailand 88 Suppl 2: S56-S62, 2007

A randomized comparison of one single dose of vaginal 50 microg misoprostol with 3 mg dinoprostone in pre-induction cervical ripening. Journal of the Medical Association of Thailand 83(9): 1026-1034, 2000

Labor induction at term: a comparison of the effects of 50 microg and 25 microg vaginal misoprostol. Clinical and Experimental Obstetrics and Gynecology 34(2): 102-105, 2007

Comparison of 25 and 50 microg vaginally administered misoprostol for preinduction of cervical ripening and labor induction. Gynecologic and Obstetric Investigation 53(1): 16-21, 2002

A comparison of vaginal misoprostol 800 microg versus 400 microg for anembryonic pregnancy: a randomized comparative trial. Journal of the Medical Association of Thailand 88 Suppl 2: S41-S47, 2007

Randomized comparison of vaginal (200 microg every 3 h) and oral (400 microg every 3 h) misoprostol when combined with mifepristone in termination of second trimester pregnancy. Human Reproduction 15(10): 2205-2208, 2000

Second-trimester pregnancy termination with 600-microg vs. 400-microg vaginal misoprostol and systematic curettage postexpulsion: a randomized trial. Contraception 77(1): 50-55, 2007

A comparison of vaginal misoprostol 800 microg versus 400 microg in early pregnancy failure: a randomized controlled trial. Journal of the Medical Association of Thailand 87 Suppl 3: S18-S23, 2011

Labor induction with 25 microg versus 50 microg intravaginal misoprostol: a systematic review. Obstetrics and Gynecology 99(1): 145-151, 2002

No benefit, but increased harm from high dose (100 microg) misoprostol for induction of labour: a randomised trial of high vs. low (50 microg) dose misoprostol. Journal of Obstetrics and Gynaecology 22(6): 614-617, 2003

Double-blind, randomized study comparing the effects of two monophasic oral contraceptives containing ethinylestradiol (20 microg or 30 microg) and levonorgestrel (100 microg or 150 microg) on lipoprotein metabolism. Contraception 69(2): 105-113, 2004

Labor induction with 25-microg misoprostol vaginal capsules. Gynecologic and Obstetric Investigation 68(4): 272-275, 2010

Vaginal misoprostol for induction of labor: 25 vs. 50 microg dose regimen. International Journal of Gynaecology and Obstetrics: the Official Organ of the International Federation of Gynaecology and Obstetrics 72(1): 25-30, 2001