+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Pre-induction cervical ripening: comparing between two vaginal preparations of dinoprostone in women with an unfavorable cervix



Pre-induction cervical ripening: comparing between two vaginal preparations of dinoprostone in women with an unfavorable cervix



Journal of Maternal-Fetal and Neonatal Medicine 27(18): 1874-1879



Prostaglandin E2 (PGE2-Dinoprostone) is accepted for both ripening of the cervix and induction of labor. As conflicting data exist concerning the efficiency and safety of different treatment modalities, we aimed to compare slow-release vaginal insert PGE2 with serial vaginal tablets of PGE2 for cervical ripening and induction of labor. A retrospective cohort study comparing all pregnancies who underwent induction of labor by either a single slow-release vaginal insert of 10 mg PGE2 (study group) to a historical control group of women who were treated with serial administration of 3 mg vaginal PGE2 tablets in a 2:1 ratio, matched by parity. Overall, 639 women were enrolled (213 treated with PGE2 tablets and 426 with slow-release vaginal inserts). Vaginal insert was associated with shorter initiation-to-ripening interval (12.4 ± 7.7 versus 18.6 ± 15.2 h, p < 0.001) and a higher rate of delivery within 24 h (61.5 versus 51.6%, p = 0.018). Vaginal insert was associated with an increased rate of tachysystole (8.0 versus 3.1%, p < 0.01); however, the rates of cesarean section or operative delivery due to non-reassuring fetal heart rate (NRFHR) were similar. On multivariable analysis, slow-release vaginal insert was independently associated with a higher rate of delivery within 24 h (OR 1.50, 95% CI 1.04-2.18). Slow-release PGE2 vaginal insert achieves cervical ripening and subsequently delivery over a shorter time period than PGE2 tablets, without increasing uterine hyperstimulation rate.

(PDF emailed within 0-6 h: $19.90)

Accession: 055092252

Download citation: RISBibTeXText

PMID: 24417462

DOI: 10.3109/14767058.2014.883375


Related references

Induction of labor and pain: a randomized trial between two vaginal preparations of dinoprostone in nulliparous women with an unfavorable cervix. Journal of Maternal-Fetal and Neonatal Medicine 24(5): 728-731, 2011

Elective cervical ripening in women beyond the 290th day of pregnancy: a randomized trial comparing 2 dinoprostone preparations. Journal of Reproductive Medicine 52(10): 945-949, 2007

Double-balloon catheter vs. dinoprostone vaginal insert for induction of labor with an unfavorable cervix. Archives of Gynecology and Obstetrics 291(6): 1221-1227, 2015

Sustained-release dinoprostone vaginal pessary with concurrent high-dose oxytocin infusion compared to sustained-release dinoprostone vaginal pessary followed 6 h later by high-dose oxytocin infusion for labor induction in women at term with unfavorable cervix: a randomized controlled trial. Gynecologic and Obstetric Investigation 71(1): 32-40, 2011

Efficiency of dinoprostone insert for cervical ripening and induction of labor in women of full-term pregnancy compared with dinoprostone gel: A meta-analysis. Drug Discoveries and Therapeutics 9(3): 165-172, 2015

A randomized comparison between misoprostol and dinoprostone for cervical ripening and labor induction in patients with unfavorable cervices. Obstetrics and Gynecology 89(4): 581-585, 1997

Effect of vaginal pH on efficacy of the controlled-release dinoprostone vaginal insert for cervical ripening/labor induction. Journal of Maternal-Fetal and Neonatal Medicine 13(4): 250-253, 2003

Comparison between vaginal misoprostol and cervical dinoprostone for cervical ripening and labor induction. Tennessee Medicine 94(1): 25-27, 2001

Comparison between vaginal misoprostol and cervical dinoprostone for cervical ripening and labor induction; a randomized study. American Journal of Obstetrics & Gynecology 178(1 PART 2): S94, 1998

Labor induction in nulliparous women with an unfavorable cervix: double balloon catheter versus dinoprostone. Journal of Perinatal Medicine 42(2): 213-218, 2014

Effect of vaginal pH on efficacy of the dinoprostone gel for cervical ripening/labor induction. American Journal of Obstetrics & Gynecology 187(4): 843-846, October, 2002

Repeated sustained release dinoprostone vaginal inserts in women with unfavorable cervix may increase the risk of postpartum hemorrhage: preliminary results. European Journal of Obstetrics, Gynecology, and Reproductive Biology 202: 81-82, 2017

Oxytocin versus sustained-release dinoprostone vaginal pessary for labor induction of unfavorable cervix with Bishop score ≥ 4 and ≤ 6: a randomized controlled trial. Journal of Obstetrics and Gynaecology Research 39(4): 790-798, 2013

Comparing two dinoprostone agents for cervical ripening and induction of labor: a randomized trial. European Journal of Obstetrics, Gynecology, and Reproductive Biology 138(2): 135-140, 2007