+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Predictors of invasive breast cancer in ductal carcinoma in situ initially diagnosed by core biopsy



Predictors of invasive breast cancer in ductal carcinoma in situ initially diagnosed by core biopsy



Asian Journal of Surgery 33(2): 76-82



Some patients who are initially diagnosed with ductal carcinoma in situ (DCIS) by core biopsy eventually have their disease upstaged to invasive carcinoma on final excision, thus warranting some form of axillary staging. This study aimed to identify the predictors of invasive breast cancer in DCIS diagnosed by core biopsy, which could then help clinicians decide which cases of biopsy-diagnosed DCIS should undergo concurrent sentinel lymph node biopsy during excision. The records of 95 consecutive patients diagnosed with pure DCIS from 100 core biopsies from January 2005 to August 2007 were retrospectively reviewed. The clinical, radiological and pathological characteristics of these 100 cases were correlated with the presence of invasion or microinvasion on excision. Factors that are associated with invasive or microinvasive foci on excisional histology are: size of target lesion on radiography ≥ 20 mm [odds ratio: 6.738 (1.050-43.236), p = 0.044] and ≤ 10 cores obtained [odds ratio: 22.343 (2.351-212.385), p = 0.007]. Underestimation of invasive breast cancer in core biopsy-diagnosed DCIS is related to the size of the lesion on radiography, as well as the number of cores obtained during biopsy.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 055111509

Download citation: RISBibTeXText

PMID: 21029943

DOI: 10.1016/S1015-9584(10)60013-9


Related references

Predictors of invasive breast cancer and lymph node involvement in ductal carcinoma in situ initially diagnosed by vacuum-assisted breast biopsy: experience of 733 cases. Breast 21(5): 635-640, 2013

Ductal carcinoma in situ diagnosed at US-guided 14-gauge core-needle biopsy for breast mass: preoperative predictors of invasive breast cancer. European Journal of Radiology 83(4): 654-659, 2014

Predictors of treatment with mastectomy, use of sentinel lymph node biopsy and upstaging to invasive cancer in patients diagnosed with breast ductal carcinoma in situ (DCIS) on core biopsy. Annals of Surgical Oncology 21(1): 66-73, 2014

Predictors of invasive breast cancer in mammographically detected microcalcification in patients with a core biopsy diagnosis of flat epithelial atypia, atypical ductal hyperplasia or ductal carcinoma in situ and recommendations for a selective approach to sentinel lymph node biopsy. Pathology, Research and Practice 208(4): 217-220, 2012

Ductal Carcinoma in Situ at Core-Needle Biopsy: Meta-Analysis of Underestimation and Predictors of Invasive Breast Cancer. Breast Diseases: A Year Book Quarterly 23(2): 165-166, 2012

Predictors of Invasive Breast Cancer in Patients With Ductal Carcinoma In Situ in Ultrasound-Guided Core Needle Biopsy. Journal of Ultrasound in Medicine, 2018

Ductal carcinoma in situ at core-needle biopsy: meta-analysis of underestimation and predictors of invasive breast cancer. Radiology 260(1): 119-128, 2011

Predictors of invasion in patients with core-needle biopsy-diagnosed ductal carcinoma in situ and recommendations for a selective approach to sentinel lymph node biopsy in ductal carcinoma in situ. Cancer 107(8): 1760-1768, 2006

Predictors of invasive breast cancer in patients with an initial diagnosis of ductal carcinoma in situ: a guide to selective use of sentinel lymph node biopsy in management of ductal carcinoma in situ. Journal of the American College of Surgeons 200(4): 516-526, 2005

Breast cancer risk associated with atypical hyperplasia and lobular carcinoma in situ initially diagnosed on core-needle biopsy. Cancer, 2017

Ductal carcinoma in situ and atypical ductal hyperplasia of the breast diagnosed at stereotactic core biopsy. Breast Journal 7(1): 14-18, 2001

Role of FDG-PET/CT in prediction of underestimation of invasive breast cancer in cases of ductal carcinoma in situ diagnosed at needle biopsy. Clinical Breast Cancer 14(5): 358-364, 2015

Risk factors for invasive breast cancer when core needle biopsy shows ductal carcinoma in situ. Archives of Surgery 145(11): 1098-1104, 2010

Ductal carcinoma in situ and atypical ductal hyperplasia of the breast diagnosed at stereotaxic core neddle biopsy A multiinstitutional study. Virchows Archiv 435(3): 193, Sept, 1999

Ductal carcinoma in situ diagnosed on core needle biopsy Predictors of invasion at follow-up. Modern Pathology 12(1): 30A, 1999