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Preferential coxsackievirus replication in proliferating/activated cells: implications for virus tropism, persistence, and pathogenesis

Preferential coxsackievirus replication in proliferating/activated cells: implications for virus tropism, persistence, and pathogenesis

Current Topics in Microbiology and Immunology 323: 149-173

Coxsackieviruses cause substantial human morbidity and mortality, but the underlying molecular mechanisms of disease remain obscure. Here, we review the effects that the cell status--both cellular activation, and the cell cycle--may have on the outcome of virus infection. We propose that these viruses have evolved to undergo productive infection in cells at the G1/S stage of the cell cycle, and to preferentially establish persistence/latent infection in quiescent cells, and we provide possible explanations for these outcomes. Finally, we consider the implications of these interactions for virus transmission and host pathology.

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Accession: 055116804

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PMID: 18357769

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