+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Preliminary study of combining T2-weighted imaging, diffusion weighted imaging and dynamic contrast enhanced-magnetic resonance imaging for diagnosing prostatic central gland cancer



Preliminary study of combining T2-weighted imaging, diffusion weighted imaging and dynamic contrast enhanced-magnetic resonance imaging for diagnosing prostatic central gland cancer



Zhonghua Yi Xue Za Zhi 94(31): 2448-2451



To explore the value of combining T₂-weighted imaging (T₂WI), diffusion weighted imaging (DWI) and dynamic contrast enhanced-magnetic resonance imaging (DCE-MRI) for qualitatively diagnosing central gland prostate cancer (CGPCa) as a gold standard with pathologic findings. A total of 42 cases with CGPCa and 42 cases with benign prostate hyperplasia (BPH) proved by pathology were followed up with T₂WI, DWI and DCE-MRI examinations retrospectively. The diagnosis sensitivity and specificity by T2WI, DWI, DCE-MRI alone and combination were calculated respectively. And the consistency of MRI diagnosis and pathological results was judged by Kappa value and the diagnostic value of each method evaluated by Az of receiver operating characteristic curve. While using T2WI alone, the diagnostic sensitivity, specificity, Az and Kappa value was 66.7%, 76.2%, 0.714 and 0.429; DWI 78.6%, 81.0%, 0.798 and 0.595; DCE-MRI 83.3%, 61.9%, 0.726 and 0.452, Az between DWI and T₂WI was statistically significant (P < 0.05) while DCE-MRI insignificant (P > 0.05). When combining T₂WI+DWI+DCE-MRI, the diagnostic sensitivity, specificity, Az and Kappa value was 90.5%, 88.1%, 0.893 and 0.786, Az between T₂WI+DWI+DCE-MRI and T₂WI, DWI and DCE-MRI was statistically significant respectively (all P < 0.05). DWI is better than T₂WI for diagnosing CGPCa. Combining T₂WI+DWI+DCE-MRI can obviously improve the diagnostic accuracy of CGPCa. And it has excellent consistency with pathological analysis.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 055123470

Download citation: RISBibTeXText

PMID: 25400054


Related references

Multiparametric magnetic resonance imaging for the detection and localization of prostate cancer: combination of T2-weighted, dynamic contrast-enhanced and diffusion-weighted imaging. Bju International 107(9): 1411-1418, 2011

Detection of prostate cancer with magnetic resonance imaging: optimization of T1-weighted, T2-weighted, dynamic-enhanced T1-weighted, diffusion-weighted imaging apparent diffusion coefficient mapping sequences and MR spectroscopy, correlated with biopsy and histopathological findings. Journal of Computer Assisted Tomography 36(1): 30-45, 2012

Improved diagnostic accuracy with multiparametric magnetic resonance imaging of the breast using dynamic contrast-enhanced magnetic resonance imaging, diffusion-weighted imaging, and 3-dimensional proton magnetic resonance spectroscopic imaging. Investigative Radiology 49(6): 421-430, 2014

Ni-57 * Dynamic Contrast-Enhanced Magnetic Resonance Perfusion Weighted Imaging (Dce-Mri) And Diffusion Weighted Imaging (Dwi) For Pharmacodynamic Evaluation Of Carboxyamidotriazole Orotate (Cto) And Temozolomide In Malignant Glioma. Neuro-Oncology 16(Suppl 5): v150-v151, 2014

Brain tumors: a multimodality approach with diffusion-weighted imaging, diffusion tensor imaging, magnetic resonance spectroscopy, dynamic susceptibility contrast and dynamic contrast-enhanced magnetic resonance imaging. Magnetic Resonance Imaging Clinics of North America 21(2): 199-239, 2013

Dynamic Susceptibility Contrast Perfusion-Weighted Magnetic Resonance Imaging and Diffusion-Weighted Magnetic Resonance Imaging in Differentiating Recurrent Head and Neck Cancer From Postradiation Changes. Journal of Computer Assisted Tomography 39(6): 849-854, 2016

Potential of Noncontrast Magnetic Resonance Imaging With Diffusion-Weighted Imaging in Characterization of Breast Lesions: Intraindividual Comparison With Dynamic Contrast-Enhanced Magnetic Resonance Imaging. Investigative Radiology 53(4): 229-235, 2018

Role of diffusion weighted imaging and magnetic resonance spectroscopy in breast cancer patients with indeterminate dynamic contrast enhanced magnetic resonance imaging findings. Magnetic Resonance Imaging 61: 66-72, 2019

Usefulness of diffusion-weighted imaging and dynamic contrast-enhanced magnetic resonance imaging in the diagnosis of prostate transition-zone cancer. Acta Radiologica 49(10): 1207-1213, 2008

Evaluation of the efficacy of neoadjuvant chemotherapy for breast cancer using diffusion-weighted imaging and dynamic contrast-enhanced magnetic resonance imaging. Neoplasma 64(3): 430-436, 2017

Accuracy of combined dynamic contrast-enhanced magnetic resonance imaging and diffusion-weighted imaging for breast cancer detection: a meta-analysis. Acta Radiologica 57(6): 651-660, 2016

Dynamic contrast-enhanced magnetic resonance imaging and diffusion-weighted magnetic resonance imaging for predicting the response of locally advanced breast cancer to neoadjuvant therapy: a meta-analysis. Journal of Medical Imaging 5(1): 011011, 2018

Dynamic contrast-enhanced imaging has limited added value over T2-weighted imaging and diffusion-weighted imaging when using PI-RADSv2 for diagnosis of clinically significant prostate cancer in patients with elevated PSA. Clinical Radiology 72(1): 23-32, 2017

Non-contrast magnetic resonance imaging for bladder cancer: fused high b value diffusion-weighted imaging and T2-weighted imaging helps evaluate depth of invasion. European Radiology 27(9): 3752-3758, 2017

Diffusion-Weighted Imaging With Apparent Diffusion Coefficient Mapping for Breast Cancer Detection as a Stand-Alone Parameter: Comparison With Dynamic Contrast-Enhanced and Multiparametric Magnetic Resonance Imaging. Investigative Radiology 53(10): 587-595, 2018