+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Preparation of Super-Stable Gold Nanorods via Encapsulation into Block Copolymer Micelles

Preparation of Super-Stable Gold Nanorods via Encapsulation into Block Copolymer Micelles

Acs Applied Materials and Interfaces 4(4): 1872-1877

Gold nanorods (GNRs) have the potential to be used as imaging and hyperthermia agents for cancer theranostics. Clinical applications of as-synthesized GNRs (i.e., cetyl trimethylammonium bromide (CTAB)-coated GNRs) are currently limited by their cytotoxicity and insufficient colloidal stability. With an aim to address these problems, we developed a self-assembly processing technique for encapsulating GNRs in poly(ethylene oxide)-poly(n-butyl acrylate) (PEO-PnBA) block copolymer (BCP) micelles. This technique uses simple steps of solvent exchange processes, based on the known principles of block copolymer self-assembly. The resultant BCP-encapsulated GNRs were found to be stable against aggregation under physiological salt conditions for indefinite periods of time, which has rarely previously been achieved by other means of encapsulation.

Please choose payment method:

(PDF emailed within 0-6 h: $19.90)

Accession: 055134195

Download citation: RISBibTeXText

PMID: 22471403

DOI: 10.1021/am300198v

Related references

Block copolymer design for stable encapsulation of N-(4-hydroxyphenyl)retinamide into polymeric micelles in mice. International Journal of Pharmaceutics 357(1-2): 318-322, 2008

Preparation of tri-block copolymer micelles loading novel organoselenium anticancer drug BBSKE and study of tissue distribution of copolymer micelles by imaging in vivo method. International Journal of Pharmaceutics 391(1-2): 292-304, 2010

Block copolymer micelles for the encapsulation and delivery of amphotericin B. Pharmaceutical Research (New York) 19(4): 418-422, 2002

Anionic Polymerization of an Amphiphilic Copolymer for Preparation of Block Copolymer Micelles Stabilized by π-π Stacking Interactions. Journal of Visualized Experiments 2016(116):, 2016

Encapsulation of curcumin in Pluronic block copolymer micelles for drug delivery applications. Journal of Biomaterials Applications 25(6): 619-639, 2011

Reversible pH-triggered encapsulation and release of pyrene by adsorbed block copolymer micelles. Langmuir 24(15): 8325-8331, 2008

Fluorescent Block Copolymer Micelles That Can Self-Report on Their Assembly and Small Molecule Encapsulation. Macromolecules 49(2): 653-662, 2016

Encapsulation of pristine fullerene C60 within block copolymer micelles through interfacial instabilities of emulsion droplets. Journal of Colloid and Interface Science 418: 81-86, 2014

Gold-labeled block copolymer micelles reveal gold aggregates at multiple subcellular sites. Langmuir 23(9): 4830-4836, 2007

Time dependent growth of the block copolymer P123 micelles near cloud point: employing heat cycling as a tool to form kinetically stable wormlike micelles. Journal of Physical Chemistry. B 113(28): 9441-9446, 2009

Redox-mediated synthesis and encapsulation of inorganic nanoparticles in shell-cross-linked cylindrical polyferrocenylsilane block copolymer micelles. Journal of the American Chemical Society 130(39): 12921-12930, 2008

Intensely phosphorescent block copolymer micelles containing gold(i) complexes. Soft Matter 14(18): 3521-3527, 2018

Block copolymer micelles as nanoreactors for self-assembled morphologies of gold nanoparticles. Journal of Physical Chemistry. B 117(10): 3028-3039, 2013

Preparation of docetaxel-loaded pH-sensitive block copolymer micelles. Yao Xue Xue Bao 43(10): 1066-1070, 2008

Effect of hydrophobicity inside PEO-PPO-PEO block copolymer micelles on the stabilization of gold nanoparticles: experiments. Langmuir 22(23): 9704-9711, 2006