+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Preparation, characterization, and biotransformation of the inclusion complex of phytosterols and hydroxypropyl-beta-cyclodextrin by Mycobacterium neoaurum



Preparation, characterization, and biotransformation of the inclusion complex of phytosterols and hydroxypropyl-beta-cyclodextrin by Mycobacterium neoaurum



Zeitschrift für Naturforschung. C, Journal of Biosciences 66(5-6): 277-282



The inclusion complex of hydroxypropyl-beta-cyclodextrin (HBbetaCD) and phytosterols (PSs) was prepared and characterized by thermogravimetric analysis (TGA) and infrared (IR) spectroscopy. Biotransformation of the inclusion complex of phytosterols and hydroxypropyl-beta-cyclodextrin (PSs-HBbetaCD) by Mycobacterium neoaurum to 1,4-androstadiene-3,17-dione and 4-androstene-3,17-dione [AD(D)] was studied. The TGA and IR results indicated that the thermal stability of PSs was improved in the complex with HBbetaCD. Biotransformation improved the solubility of PSs in the aqueous medium a lot because the AD(D) production was increased remarkably compared with the control, but growth of the bacteria was inhibited in the presence of HBbetaCD. The optimal inclusion ratio, ultrasonic treating time, dosage, and time of addition of PSs-HBbetaCD complexe were found to be 2:1, 10 min, 1.5 g/30 ml medium, and 48 h after incubation, respectively. This inclusion technique not only increased the availability of the substrates for the microorganisms, but also the capability of these microorganisms to produce AD(D) from PSs.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 055137516

Download citation: RISBibTeXText

PMID: 21812345


Related references

Influence of hydroxypropyl-β-cyclodextrin on phytosterol biotransformation by different strains of Mycobacterium neoaurum. Journal of Industrial Microbiology and Biotechnology 39(9): 1253-1259, 2013

Physicochemical characterization, in vitro dissolution behavior, and pharmacodynamic studies of rofecoxib-cyclodextrin inclusion compounds. preparation and properties of rofecoxib hydroxypropyl beta-cyclodextrin inclusion complex: a technical note. Aaps Pharmscitech 6(1): E83-E90, 2005

Preparation and characterization of the inclusion complex of furosemide with hydroxypropyl-beta-cyclodextrin. Journal of Biomaterials Applications 17(3): 197-206, 2003

Preparation and characterization of dihydroartemisinin/ hydroxypropyl-beta-cyclodextrin inclusion complex. Yao Xue Xue Bao 47(4): 529-534, 2013

Preparation and characterization of simvastatin/hydroxypropyl-beta-cyclodextrin inclusion complex using supercritical antisolvent (SAS) process. European Journal of Pharmaceutics and Biopharmaceutics 66(3): 413-421, 2007

Preparation and characterization of inclusion complexes of prazosin hydrochloride with beta-cyclodextrin and hydroxypropyl-beta-cyclodextrin. Journal of Pharmaceutical and Biomedical Analysis 40(1): 122-127, 2005

Preparation, identification and inclusion actions of irisquinone hydroxypropyl-beta-cyclodextrin inclusion complex. Yao Xue Xue Bao 40(4): 369-372, 2005

Preparation and properties of phytosterols with hydroxypropyl ?-cyclodextrin inclusion complexes. European Food Research and Technology 235(6): 1039-1047, 2012

Preparation and characterization of the inclusion complex of hypocrellin A with hydroxypropyl-β-cyclodextrin. European Food Research and Technology 231(5): 781-788, 2010

Preparation and properties of valdecoxib-hydroxypropyl beta-cyclodextrin inclusion complex. Pda Journal of Pharmaceutical Science and Technology 61(3): 175-182, 2007

Preparation process of rutacarpine-hydroxypropyl-beta-cyclodextrin inclusion complex. Zhongguo Zhong Yao Za Zhi 39(5): 828-832, 2014

Characterization of an inclusion complex of cholesterol and hydroxypropyl-beta-cyclodextrin. European Journal of Pharmaceutics and Biopharmaceutics 46(3): 355-360, 1999

Preparation, characterization and antimicrobial activity of inclusion complex of biochanin A with (2-hydroxypropyl)-β-cyclodextrin. Journal of Pharmacy and Pharmacology 70(11): 1485-1493, 2018

Development of a myricetin/hydroxypropyl-β-cyclodextrin inclusion complex: preparation, characterization, and evaluation. Carbohydrate Polymers 110: 329-337, 2015

The study on the preparation and spectroscopic properties of hydroxypropyl-beta-cyclodextrin/glipizide inclusion complex. Guang Pu Xue Yu Guang Pu Fen Xi 28(3): 711-714, 2008