+ Site Statistics
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Prevalence of depression symptoms and serum levels of interleukin-6 in hemodialysis patients

Prevalence of depression symptoms and serum levels of interleukin-6 in hemodialysis patients

Psychiatry and Clinical Neurosciences 68(4): 275-282

In hemodialysis patients, depression appears as the most common psychopathological condition. States of advanced chronic kidney disease and dialysis are associated with a state of chronic inflammation. Depression has been linked to activation of the immune system characterized by high levels of pro-inflammatory cytokines. In this study, we investigated the possible correlations between depression, and interleukin-6 (IL-6) in hemodialysis patients. Seventy-five hemodialysis patients were enrolled in a cross-sectional study from September to November 2011 in Pelotas, Rio Grande do Sul. Demographic data were obtained from a questionnaire and the Beck Depression Inventory (BDI) was used to determine the presence or absence of depression symptoms. Biochemical parameters, dialysisdosage delivery, and IL-6 serum levels were measured. Prevalence of depression among hemodialysis patients was 48% (BDI ≥ 14). In biochemical assessments, depressed patients showed a decrease in urea (P = 0.01) and increase of IL-6 (P = 0.04) levels. The correlation analysis between BDI scores and the biochemical variables showed that BDI was negatively correlated with urea (P = 0.03) and potassium (P = 0.04), but not with IL-6 levels. Hemodialysis patients with depression showed higher levels of IL-6 but the severity of depressive symptoms was not correlated with levels of this cytokine.

(PDF emailed within 0-6 h: $19.90)

Accession: 055157022

Download citation: RISBibTeXText

PMID: 24372974

DOI: 10.1111/pcn.12130

Related references

Fatigue is associated with serum interleukin-6 levels and symptoms of depression in patients on chronic hemodialysis. Journal of Pain and Symptom Management 49(3): 578-585, 2015

Lower serum levels of interleukin-6 in a population sample with symptoms of depression than in a population sample without symptoms of depression. Physiological Research 59(1): 121-126, 2010

Serum levels of interleukin-6 and interleukin-10 in relation to depression scores in patients with cardiovascular risk factors. Behavioral Medicine 37(3): 105-112, 2012

Is there any relationship between serum levels of interleukin-10 and atherosclerosis in hemodialysis patients?. Scandinavian Journal of Urology and Nephrology 39(5): 405-409, 2005

Increased serum levels of interleukin-12 may be associated with Th1 differentiation in hemodialysis patients. Nephron 90(4): 503-504, 2002

Dissociation of serum alkaline phosphatase levels and musculoskeletal symptoms ms from intact parathyroid hormone levels i pth in chronic hemodialysis patients chp treated with intravenous 1 25 dihydroxyvitamin d. Kidney International 37(1): 465, 1990

Serum erythropoietin and interleukin-6 levels in hemodialysis patients with hepatitis virus infection. Journal of Interferon & Cytokine Research 19(4): 369-373, 1999

An intradialytic increase in serum interleukin-6 levels is associated with an increased mortality in hemodialysis patients. International Journal of Artificial Organs 38(5): 237-243, 2016

Depression and serum interleukin-6 levels in patients on dialysis. Psychiatria Danubina 27(2): 168-173, 2015

Associations of self-reported physical activity types and levels with quality of life, depression symptoms, and mortality in hemodialysis patients: the DOPPS. Clinical Journal of the American Society of Nephrology 9(10): 1702-1712, 2015

The effect of treatment with N-acetylcysteine on the serum levels of C-reactive protein and interleukin-6 in patients on hemodialysis. Saudi Journal of Kidney Diseases and Transplantation 25(1): 66-72, 2014

Low doses of recombinant human erythropoietin raise serum interleukin-2 levels in hemodialysis patients. JN Journal of Nephrology 9(1): 30-34, 1996

Elevated serum levels of interleukin 2 receptors are present in patients maintained on chronic hemodialysis. Clinical Research 34(2): 605A, 1986

Low serum albumin and high ferritin levels in chronic hemodialysis patients with major depression. Psychiatry Research 152(2-3): 277-280, 2007

Interleukin-18 and CD30 serum levels in patients with moderate-severe depression. Mediators of Inflammation 11(4): 265-267, 2002