+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Prevalence of genetic variants associated with cardiovascular disease risk and drug response in the Southern Indian population of Kerala



Prevalence of genetic variants associated with cardiovascular disease risk and drug response in the Southern Indian population of Kerala



Indian Journal of Human Genetics 20(2): 175-184



This study reports the prevalence of five clinically significant variants associated with increased risk of cardiovascular disorders, and variable responses of individuals to commonly prescribed cardiovascular drugs in a South Indian population from the state of Kerala. Genomic DNA isolated from 100 out-patient samples from Kerala were sequenced to examine the frequency of clinically relevant polymorphisms in the genes MYBPC3 (cardiomyopathy), SLCO1B1 (statin-induced myopathy), CYP2C9, VKORC1 (response to warfarin) and CYP2C19 (response to clopidogrel). Our analyses revealed the frequency of a 25 bp deletion variant of MYBPC3 associated with risk of cardiomyopathy was 7%, and the SLCO1B1 "C" allele associated with risk for statin-induced myopathy was 15% in this sample group. Among the other variants associated with dose-induced toxicity of warfarin, VKORC1 (c.1639G>A), was detected at 22%, while CYP2C9*3 and CYP2C9*2 alleles were present at a frequency of 15% and 3% respectively. Significantly, the tested sample population showed high prevalence (66%) of CYP2C19*2 variant, which determines response to clopidogrel therapy. We have identified that certain variants associated with cardiovascular disease and related drug response in the five genes, especially those in VKORC1, CYP2C19 and MYBPC3, are highly prevalent in the Kerala population, with almost 2 times higher prevalence of CYP2C19*2 variant compared with other regions in the country. Since the variants chosen in this study have relevance in disease phenotype and/or drug response, and are detected at a higher frequency, this study is likely to encourage clinicians to perform genetic testing before prescribing therapy.

(PDF emailed within 0-6 h: $19.90)

Accession: 055157999

Download citation: RISBibTeXText

PMID: 25400347

DOI: 10.4103/0971-6866.142896


Related references

Genetic risk score and cardiovascular mortality in a southern european population with coronary artery disease. International Journal of Clinical Practice 71(6), 2017

Prevalence of Factor V Genetic Variants Associated With Indian APCR Contributing to Thrombotic Risk. Clinical and Applied Thrombosis/Hemostasis 23(6): 596-600, 2015

Classical rather than genetic risk factors account for high cardiovascular disease prevalence in Lithuania: A cross-sectional population study. Advances in Medical Sciences 62(1): 121-128, 2017

Genetic variants and risk of asthma in an American Indian population. Annals of Allergy, Asthma & Immunology 119(1): 31-36.E1, 2017

Functional genetic variants of CTLA-4 and risk of tobacco-related oral carcinoma in high-risk North Indian population. Human Immunology 74(3): 348-352, 2013

Role of Established Type 2 Diabetes-Susceptibility Genetic Variants in a High Prevalence American Indian Population. Diabetes 64(7): 2646-2657, 2015

Interaction between fibrinogen and IL-6 genetic variants and associations with cardiovascular disease risk in the Cardiovascular Health Study. Annals of Human Genetics 74(1): 1-10, 2010

Cytochrome P450 genetic variants and hypertension risk in South Indian population. Journal of Young Pharmacists 6(1): 22-26, 2014

Genetic variants and haplotypes of lipoprotein associated phospholipase A2 and their influence on cardiovascular disease (The Ludwigshafen Risk and Cardiovascular Health Study). Journal of Thrombosis and Haemostasis 7(1): 41-48, 2008

Trends in Cardiovascular Disease Risk Factor Prevalence and Estimated 10-Year Cardiovascular Risk Scores in a Large Untreated French Urban Population: The CARVAR 92 Study. Plos One 10(4): E0124817, 2016

Genetic Risk Analysis of Coronary Artery Disease in a Population-based Study in Portugal, Using a Genetic Risk Score of 31 Variants. Arquivos Brasileiros de Cardiologia 111(1): 50-61, 2018

Genetic variants of the promoter of the heme oxygenase-1 gene and their influence on cardiovascular disease (the Ludwigshafen Risk and Cardiovascular Health study). Bmc Medical Genetics 10: 36, 2009

Common genetic variants in pre-microRNAs and risk of breast cancer in the North Indian population. Ecancermedicalscience 8: 473, 2014

Prevalence of cardiovascular disease risk factor clustering among the adult population of China: results from the International Collaborative Study of Cardiovascular Disease in Asia (InterAsia). Circulation 112(5): 658-665, 2005

Estrogen receptor α genetic variants and the risk of stroke in a South Indian population from Andhra Pradesh. Clinica Chimica Acta; International Journal of Clinical Chemistry 411(21-22): 1817-1821, 2011