+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Prevalence of hepatitis delta virus (HDV) infection in chronic hepatitis B patients with unusual clinical pictures



Prevalence of hepatitis delta virus (HDV) infection in chronic hepatitis B patients with unusual clinical pictures



Hepatitis Monthly 13(8): E6731



Probably 5% of the HBV carriers have HDV super infection. The risk of fulminant hepatitis, cirrhosis and hepatocellular carcinoma is higher in superinfection than the settings when HBV is alone. The aim of this study was to evaluate the prevalence of HDV in Iranian HBV isolates and to compare their clinical and virological pictures as well as their HDV genetic variations with other worldwide isolates. 81 carriers with positive results for HBsAg with upper limit ranges of ALT and low or undetectable levels of HBV viral load who did not respond to HBV therapy were selected. After RT amplification of HDV Delta antigen, direct sequencing and phylogenetic study were performed to explore the genotype(s) and nucleotide/amino acid variations. 12 (14.8%) patients had positive results for both HDV RNA and anti-HDV. The mean ALT level was higher in HDV positive patients (75.9 U/ML) than HBV-mono-infected individuals; however, the mean HBV viral load was lower in coinfected patients than HBV-mono-infected patients. Phylogenetically, genotype I was the only detected genotype, and the most closely related isolates were of Turkish, Italian and Mongolian origin. Within the delta Ag, there were 326 nucleotide mutations, of which 111 and 215 were silent and missense, respectively. The total number of amino acid substitution was 148; most were located in known functional/epitopic domains. There was no correlation between the numbers of amino acid mutations, with clinical, virological status of the patients. HDV should be suspected in HBV carriers with unusual clinical and virological pictures. Relatedness of Iranian HDV isolates to Italian and Turkish sequences proposed a common Caucasian origin for the distribution of HDV genotype I in this ethnic group.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 055158423

Download citation: RISBibTeXText

PMID: 24098308

DOI: 10.5812/hepatmon.6731


Related references

High prevalence of hepatitis delta virus among patients with chronic hepatitis B virus infection and HIV-1 in an intermediate hepatitis B virus endemic region. Journal of the International Association of Providers of Aids Care 13(1): 85-90, 2014

Search for hepatitis delta virus (HDV) infection in hepatitis C patients in northeastern Poland. Comparison with anti-HDV prevalence in chronic hepatitis B. European Journal of Epidemiology 18(6): 559-561, 2003

Search for Hepatitis Delta Virus (Hdv) Infection in Hepatitis C Patients in North-Eastern Poland. Comparison with Anti-Hdv Prevalence in Chronic Hepatitis B. European Journal of Epidemiology 18(6): 559-561, 2003

Prevalence and clinical associations of previous and occult hepatitis B virus infection in hepatitis C virus positive and hepatitis B virus surface antigen negative patients with chronic liver disease. Hepatology 34(4 Pt 2): 562A, 2001

Prevalence and significance of hepatitis GB virus-C/hepatitis G virus viremia in a large cohort of patients with chronic hepatitis B infection, with chronic hepatitis C infection, and on renal replacement therapy in Hong Kong. Digestive Diseases & Sciences 47(2): 432-437, 2002

Prevalence of hepatitis delta virus (HDV) infection in chronic hepatitis B patients in eastern Turkey: still a serious problem to consider. Journal of Viral Hepatitis 18(7): 518-524, 2011

Elimination of Hepatitis Delta Virus Infection After Loss of Hepatitis B Surface Antigen in Patients With Chronic Delta Hepatitis. Journal Of Medical Virology. 44(4): 389-392, 1994

Prevalence and clinical significance of hepatitis D virus co-infection in patients with chronic hepatitis B in Korea. Journal of Medical Virology 83(7): 1172-1177, 2011

Suppression of hepatitis delta virus by concurrent hepatitis C virus superinfection in patients with chronic hepatitis B virus infection. Progress in Clinical and Biological Research 382: 229-234, 1993

Prevalence of the core promoter mutants of hepatitis B virus in Chinese asymptomatic hepatitis B virus carriers and patients with chronic hepatitis B infection. Hepatology 26(4 Part 2): 525A, 1997

Concurrent hepatitis C virus and hepatitis delta virus superinfection in patients with chronic hepatitis B virus infection. Journal of Medical Virology 37(4): 294-297, 1992

Prevalence of hepatitis d virus infection among patients with chronic hepatitis B attending birjand hepatitis clinic (East of iran) in 2012. Hepatitis Monthly 13(8): E11168, 2013

Prevalence of hepatitis delta virus infection among hepatitis B virus surface antigen positive patients circulating in the largest province of Pakistan. Virology Journal 7: 283, 2010

Hepatitis C virus infection: clinical, virologic and pathologic features: hepatic steatosis in chronic hepatitis C virus infection: prevalence and clinical correlation. Journal of Gastroenterology and Hepatology 16(2): 190-195, 2001

Low prevalence of chronic hepatitis C virus infection in B-cell non-Hodgkin's lymphoma patients from a population with a high prevalence of healthy hepatitis c virus carriers. British Journal of Haematology 109(1): 249-250, 2000