+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Prevalence of hepatitis delta virus infection among hepatitis B virus surface antigen positive patients circulating in the largest province of Pakistan



Prevalence of hepatitis delta virus infection among hepatitis B virus surface antigen positive patients circulating in the largest province of Pakistan



Virology Journal 7: 283



Hepatitis delta virus (HDV) and Hepatitis B virus (HBV) co-infection is well known to induce a spectrum of acute and chronic liver diseases which further advance to cirrhosis, fulminant hepatitis and hepatocellular carcinoma (HCC). The aim of the present study was to determine the prevalence of hepatitis D virus super-infection among hepatitis B surface antigen (HBsAg) positive individuals in the highly populated province of Pakistan which is not well known. Sera samples were subjected to HBsAg and anti-HDV screening and finally anti-HDV and HBsAg positive coinfected samples were used for HDV active RNA confirmation using nested polymerase chain reaction (PCR). Out of total 200 HBsAg positive samples by rapid device, 96 (48%) were also found reactive for HBsAg using enzyme linked immunosorbant assay (ELISA). Out of these HBsAg ELISA positive samples, 80 (88.8%) were anti-HDV ELISA positive which were then subjected to PCR. The amplification results further confirmed 24 (30%) samples to be HDV RNA positive. HDV super-infection was more common in male patients than female patients (81% VS 19%). The current study shows a high prevalence rate of HDV-HBV co-infection in Pakistan that tends to increase over time.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 055158424

Download citation: RISBibTeXText

PMID: 20977704

DOI: 10.1186/1743-422x-7-283


Related references

Prevalence and clinical associations of previous and occult hepatitis B virus infection in hepatitis C virus positive and hepatitis B virus surface antigen negative patients with chronic liver disease. Hepatology 34(4 Pt 2): 562A, 2001

Correlation of hepatitis b virus hepatitis d virus and human immunodeficiency virus type i infection markers in hepatitis b surface antigen positive haemophiliacs and patients without haemophilia with clinical and histopathological outcome of hepatitis. European Journal of Pediatrics 151(2): 90-94, 1992

Prevalence of hepatitis D virus infection in hepatitis B surface antigen-positive subjects in Golestan province, northeast Iran. Journal of Microbiology Immunology and Infection 41(3): 227-230, 2008

Prevalence of positive Hepatitis Delta Virus in patients with positive hepatitis B surface antigen and its correlative factors in Sari. Journal Of Mazandaran University Of Medical Sciences: 67, 696, 2008

Immunoglobulin and hepatitis B surface antigen-specific circulating immune complexes in chronic hepatitis with hepatitis delta virus infection. Journal of Medical Virology 30(1): 25-29, 1990

High prevalence of hepatitis C virus infection in the largest province of Pakistan. Journal of Digestive Diseases 9(2): 95, 2008

Hepatitis D virus infection among hepatitis B virus surface antigen positive individuals in Upper Egypt: Prevalence and clinical features. Journal of Infection and Public Health 12(3): 350-356, 2019

Interferon-Free Regimens in Hepatitis B Surface Antigen/Anti-Hepatitis C Virus Positive Patients: The Need to Control Hepatitis B Virus Replication to Avoid Hepatitis B Virus Reactivation. Clinical Gastroenterology and Hepatology 15(11): 1800-1802, 2017

Elimination of Hepatitis Delta Virus Infection After Loss of Hepatitis B Surface Antigen in Patients With Chronic Delta Hepatitis. Journal Of Medical Virology. 44(4): 389-392, 1994

Delta infection in asymptomatic carriers of hepatitis B surface antigen: low prevalence of delta activity and effective suppression of hepatitis B virus replication. Hepatology 8(5): 1121-1124, 1988

Direct detection of hepatitis b virus dna in human serum of hepatitis b surface antigen positive hepatitis b e antigen positive and hepatitis b surface antigen positive anti hepatitis b e antigen antibody carriers by a simplified molecular hybridization test. Hepatology 2(5): 723, 1982

Hepatitis b virus infection has an etiological role in cirrhotic patients who are hepatitis b surface antigen negative but positive for hepatitis b surface or core antigen. Hepatology 10(4): 577, 1989

Hepatitis B virus genotypes and hepatitis B surface antigen mutations in family contacts of hepatitis B virus infected patients with occult hepatitis B virus infection. Journal of Gastroenterology and Hepatology 24(4): 588-598, 2009

Prevalence of infection with hepatitis delta virus (HDV) among carriers of hepatitis B surface antigen in Amazonas State, Brazil. Transactions of the Royal Society of Tropical Medicine and Hygiene 82(3): 469-471, 1988

High prevalence of hepatitis delta virus among patients with chronic hepatitis B virus infection and HIV-1 in an intermediate hepatitis B virus endemic region. Journal of the International Association of Providers of Aids Care 13(1): 85-90, 2014