+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Preventable maternal risk factors and association of genital infection with fetal growth restriction

Preventable maternal risk factors and association of genital infection with fetal growth restriction

Gynecologic and Obstetric Investigation 70(4): 291-298

Maternal risk factors may interfere with mechanisms regulating fetal growth. The aim of the present study was to determine which sociodemographic and reproductive risk factors may be related to fetal growth restriction (FGR), with a special focus on determinants possible for preventive intervention. The study period is from May 2007 until December 2009. Data about lifestyle habits were collected by use of a detailed questionnaire in 65 women who attended Riga Maternity Hospital with the confirmed diagnosis of intrauterine FGR of a singleton fetus, and in 65 matched controls with normal pregnancies. Being unmarried (p = 0.04), having pregnancy-related blood pressure rise (p = 0.02), current (p = 0.01) and pre-pregnancy smoking (p = 0.01) and history of more than 3 pregnancy failures (p = 0.04) were more frequent in women with FGR than controls. Surprisingly, the finding of genital infection (STI) during pregnancy (p = 0.006) was also strongly associated with FGR. Obviously, several maternal risk factors play an important role in FGR. Besides refraining from smoking, screening and treating for STI may not only prevent preterm birth, but also FGR. Identifying such anticipating factors would likely have the potential impact if detected before conception, or as early as possible in gestation.

Please choose payment method:

(PDF emailed within 0-6 h: $19.90)

Accession: 055164748

Download citation: RISBibTeXText

PMID: 21051850

DOI: 10.1159/000314020

Related references

Maternal and fetal risk factors affecting perinatal mortality in early and late fetal growth restriction. Taiwanese Journal of Obstetrics and Gynecology 54(6): 700-704, 2016

Maternal/fetal mortality and fetal growth restriction: role of nitric oxide and virulence factors in intrauterine infection in rats. American Journal of Obstetrics and Gynecology 205(1): 83.E1-7, 2012

Angiogenic factors in maternal circulation and the risk of severe fetal growth restriction. American Journal of Epidemiology 173(6): 630-639, 2011

Prevalence, risk factors, maternal and fetal morbidity and mortality of intrauterine growth restriction and small-for-gestational age. Journal de Gynecologie, Obstetrique et Biologie de la Reproduction 42(8): 895-910, 2014

Association between maternal blood cadmium during pregnancy and birth weight and the risk of fetal growth restriction: the EDEN mother-child cohort study. Reproductive Toxicology 34(4): 622-627, 2013

Maternal floor infarction and massive perivillous fibrin deposition: histological definitions, association with intrauterine fetal growth restriction, and risk of recurrence. Pediatric and Developmental Pathology 5(2): 159-164, 2002

Risk factors for term or near-term fetal growth restriction in the absence of maternal complications. American Journal of Perinatology 21(4): 227-234, 2004

The association between fetal growth restriction and advanced maternal age. American Journal of Obstetrics and Gynecology 220(1): S168-S169, 2019

Associations of intrauterine growth restriction with placental pathological factors, maternal factors and fetal factors; clinicopathological findings of 257 Japanese cases. Histology and Histopathology 28(1): 127-132, 2013

The effects of acute nutrient restriction in the mid-gestational ewe on maternal and fetal nutrient status, the expression of placental growth factors and fetal growth. Placenta 26(1): 25-33, 2005

The association between pentraxin 3 in maternal circulation and pathological intrauterine fetal growth restriction. European Journal of Obstetrics, Gynecology, and Reproductive Biology 185: 1-8, 2015

Maternal serum activin A levels in association with intrauterine fetal growth restriction. Bjog 110(3): 306-310, 2003

Porphyromonas gingivalis infection during pregnancy increases maternal tumor necrosis factor alpha, suppresses maternal interleukin-10, and enhances fetal growth restriction and resorption in mice. Infection and Immunity 71(9): 5156-5162, 2003

Maternal rather than fetal factors have the greatest effect on growth restriction. Nursing Standard 26(49): 16-17, 2012

Angiogenic growth factors in maternal and fetal serum in pregnancies complicated with intrauterine growth restriction. Journal of Obstetrics and Gynaecology 34(3): 218-220, 2015