+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Primary biliary cirrhosis-specific autoantibodies in first degree relatives of Greek primary biliary cirrhosis patients



Primary biliary cirrhosis-specific autoantibodies in first degree relatives of Greek primary biliary cirrhosis patients



World Journal of Gastroenterology 18(34): 4721-4728



To determine the prevalence and significance of primary biliary cirrhosis (PBC)-specific autoantibodies in first-degree relatives (FDRs) of Greek PBC patients. The presence of antimitochondrial antibodies (AMA) and PBC-specific antinuclear antibodies (ANA) were determined using indirect immunofluorescence assays, dot-blot assays, and molecularly based enzyme-linked immunosorbent assays in 101 asymptomatic for liver-related symptoms FDRs of 44 PBC patients. In order to specify our results, the same investigation was performed in 40 healthy controls and in a disease control group consisting of 40 asymptomatic for liver-related symptoms FDRs of patients with other autoimmune liver diseases namely, autoimmune hepatitis-1 or primary sclerosing cholangitis (AIH-1/PSC). AMA positivity was observed in 19 (only 4 with abnormal liver function tests) FDRs of PBC patients and none of the healthy controls. The prevalence of AMA was significantly higher in FDRs of PBC patients than in AIH-1/PSC FDRs and healthy controls [18.8%, 95% confidence interval (CI): 12%-28.1% vs 2.5%, 95% CI: 0.1%-14.7%, P = 0.01; 18.8%, 95% CI: 12%-28.1% vs 0%, 95% CI: 0%-10.9%, P = 0.003, respectively]. PBC-specific ANA positivity was observed in only one FDR from a PSC patient. Multivariate analysis showed that having a proband with PBC independently associated with AMA positivity (odds ratio: 11.24, 95% CI: 1.27-25.34, P = 0.03) whereas among the investigated comorbidities and risk factors, a positive past history for urinary tract infections (UTI) was also independently associated with AMA detection in FDRs of PBC patients (odds ratio: 3.92, 95% CI: 1.25-12.35, P = 0.02). In FDRs of Greek PBC patients, AMA prevalence is significantly increased and independently associated with past UTI. PBC-specific ANA were not detected in anyone of PBC FDRs.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 055174544

Download citation: RISBibTeXText

PMID: 23002341


Related references

Autoantibodies, immunoglobulins and HLA in relatives of patients with primary biliary cirrhosis. Revista Espanola de Las Enfermedades del Aparato Digestivo 64(5): 395-399, 1983

CTLA4 polymorphisms in primary biliary cirrhosis patients and first degree relatives of cretan origin. Gut 60(Suppl 1): A237-A237, 2011

Increased prevalence of antimitochondrial antibodies in first-degree relatives of patients with primary biliary cirrhosis. Hepatology 46(3): 785-792, 2007

Elevated level of serum Mn-superoxide dismutase in patients with primary biliary cirrhosis: possible involvement of free radicals in the pathogenesis in primary biliary cirrhosis. Journal of Laboratory and Clinical Medicine 118(5): 476-483, 1991

Elevated level of serum manganese superoxide dismutase in patients with primary biliary cirrhosis possible involvement of free radicals in the pathogenesis in primary biliary cirrhosis. Journal of Laboratory & Clinical Medicine 118(5): 476-483, 1991

Antinuclear antibodies directed to a 200-kilodalton polypeptide of the nuclear envelope in primary biliary cirrhosis. A clinical and immunological study of a series of 150 patients with primary biliary cirrhosis. Gastroenterology 99(1): 181-186, 1990

Aminoterminal propeptide of type III procollagen and hyaluronan in patients with primary biliary cirrhosis: Markers of fibrosis in primary biliary cirrhosis. Journal of Gastroenterology and Hepatology 11(11): 1016-1020, 1996

Mo1001 Low Incidence of Primary Biliary Cirrhosis (Pbc) in First Degree Relatives (Fdrs) of Patients With Pbc With Long Term Follow Up. Gastroenterology 148(4): S-1060, 2015

Increased levels of chemokine receptor CXCR3 and chemokines IP-10 and MIG in patients with primary biliary cirrhosis and their first degree relatives. Journal of Autoimmunity 25(2): 126-132, 2005

Primary biliary cirrhosis-specific autoantibodies in patients with systemic sclerosis. Digestive and Liver Disease 41(12): 916; Author Reply 916, 2009

Heterogeneity of combinatorial human autoantibodies against PDC-E2 and biliary epithelial cells in patients with primary biliary cirrhosis. Hepatology. 20(3): 574-583, 1994

Association of endothelial nitric oxide synthase polymorphisms in primary biliary cirrhosis (PBC) patients and first degree relatives (FDR) of cretan origin. Gut 60(Suppl 1): A237-A238, 2011

Low incidence of primary biliary cirrhosis (PBC) in the first-degree relatives of PBC probands after 8 years of follow-up. Liver International 36(9): 1378-1382, 2016

Biochemical, histological parameters and response to UDCA treatment in primary biliary cirrhosis and primary biliary cirrhosis-autoimmune hepatitis overlap syndrome. Journal of Hepatology 34(Suppl. 1): 216, 2001

Intrahepatic Th1- and Th2-related chemokine receptor mRNA levels in primary biliary cirrhosis and chronic hepatitis C An imbalance between Th1 and Th2 in primary biliary cirrhosis. Hepatology 32(4 Pt 2): 168A, 2000