+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Co-carcinogenesis: Human Papillomaviruses, Coal Tar Derivatives, and Squamous Cell Cervical Cancer

Co-carcinogenesis: Human Papillomaviruses, Coal Tar Derivatives, and Squamous Cell Cervical Cancer

Frontiers in Microbiology 8: 2253

Cervical cancer (CC) is the fourth most common cancers among women worldwide. Human papillomaviruses (HPVs) play a major role in the etiology of CC, with several lines of epidemiologic and experimental evidence supporting a role for non-viral (co-carcinogens) and host genetic factors in controlling the risk for progression to neoplasia among HPV-infected individuals. The role of co-carcinogens in the development of CC is significant in the developing world where poor sanitation and other socio-economic conditions increase the infectious cancer burden. Here, we discuss how exposure to environmental factors such as coal tar derivatives from cigarette smoking, tar-based sanitary products, and inhaled smoke from biomass-burning stoves, could activate host pathways involved in development of HPV-associated squamous cell cancers in resource-limited settings. Understanding interactions between these pathways with certain oncogenic HPV genotypes may guide implementation of strategies for control and treatment of HPV-associated cancers that develop in populations at high risk of exposure to various co-carcinogens.

Please choose payment method:

(PDF emailed within 0-6 h: $19.90)

Accession: 055195459

Download citation: RISBibTeXText

PMID: 29180993

DOI: 10.3389/fmicb.2017.02253

Related references

Human papillomaviruses and cervical cancer in Bangkok. II. Risk factors for in situ and invasive squamous cell cervical carcinomas. American Journal of Epidemiology 153(8): 732-739, 2001

Human papillomavirus DNA and antibodies to human papillomaviruses 16 E2, L2, and E7 peptides as predictors of survival in patients with squamous cell cervical cancer. Journal of Clinical Oncology 15(2): 610-619, 1997

The Association of High Risk Human Papillomaviruses in Patients With Cervical Cancer: An Evidence Based Study on Patients With Squamous Cell Dysplasia or Carcinoma for Evaluation of 23 Human Papilloma Virus Genotypes. Jundishapur Journal of Microbiology 9(4): E32728, 2016

Head and neck squamous cell carcinomas associated with human papillomaviruses and an increased incidence of cervical pathology. Otolaryngology--Head and Neck Surgery 99(3): 296-301, 1988

Differential cell cycle regulation by low and high risk human papillomaviruses in low grade cervical squamous intraepithelial lesions. Journal of Pathology 186(Suppl. ): 7A, 1998

Basal cell tetrasomy in low-grade cervical squamous intraepithelial lesions infected with high-risk human papillomaviruses. Cancer Research 57(19): 4210-4213, 1997

Monoclonal expansion with integration of high-risk type human papillomaviruses is an initial step for cervical carcinogenesis: Association of clonal status and human papillomavirus infection with clinical outcome in cervical intraepithelial neoplasia. Laboratory Investigation 83(10): 1517-1527, 2003

Human papillomaviruses, cell cycle and cervical cancer. Journal de Gynecologie Obstetrique et Biologie de la Reproduction 29(1): 13-20, 2000

A brief synopsis of the role of human papillomaviruses in cervical carcinogenesis. American Journal Of Obstetrics & Gynecology. 175(4 Part 2): 1091-1098, 1996

Human papillomaviruses and cervical neoplasia: a model for carcinogenesis. International Journal of Gynecological Pathology 19(1): 16-28, 2000

Molecular basis of cervical carcinogenesis by high-risk human papillomaviruses. Uirusu 58(2): 141-154, 2008

Human papillomaviruses 16 and 18 are involved in the carcinogenesis of many squamous cell carcinomas of penis sscp and male urethra sccu an epidemiologic survey using genetic analysis of primary recurrent and metastatic lesions by differential polymerase chain reaction d pcr. Journal of Urology 147(4 Suppl.): 287A, 1992

Human papillomavirus hpv infections as a possible etiological factor in cervical squamous cell carcinogenesis. Contraception Fertilite Sexualite 15(10): 963-973, 1987

Identification and characterization of genes involved in the carcinogenesis of human squamous cell cervical carcinoma. International Journal of Cancer 98(3): 419-426, 20 March, 2002

Recurrent integration of human papillomaviruses 16, 45, and 67 near translocation breakpoints in new cervical cancer cell lines. Cancer Research 59(21): 5615-5624, 1999