+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Cognitive Reserve Hypothesis in Frontotemporal Dementia: Evidence from a Brain SPECT Study in a Series of Greek Frontotemporal Dementia Patients

Cognitive Reserve Hypothesis in Frontotemporal Dementia: Evidence from a Brain SPECT Study in a Series of Greek Frontotemporal Dementia Patients

Neuro-Degenerative Diseases 18(2-3): 69-73

Cognitive reserve (CR) mediates the clinical expression of brain pathology in Alzheimer's disease, while there are much less relevant data in frontotemporal dementia (FTD). In the present study we examined whether CR, measured using the Cognitive Reserve Index (CRI), correlated with regional cerebral blood flow (rCBF) in Greek FTD patients. Eighty FTD patients, i.e., 47 with behavioral variant FTD (bvFTD) and 33 with primary progressive aphasia (PPA), were enrolled into this study. CR was assessed using the CRI questionnaire, which provides a total score (CRI) and 3 subscores, i.e., CRI-education, CRI-working activity, and CRI-leisure time. The FTD-Clinical Dementia Rating Scale was used to assess the severity of dementia and a brain SPECT study was performed to measure rCBF. Finally, multiple regression analyses were conducted to explore correlations between CR indices and frontotemporal rCBF. In both the bvFTD and the PPA groups, higher scores in the CRI, CRI-education, and CRI-leisure time correlated with lower rCBF in the bilateral frontal and left temporal cortex, respectively, controlling for age, sex, time since symptom onset, and disease severity. In the present study, lifetime participation in leisure time activities was found to mitigate the burden of disease in bvFTD and PPA patients. Moreover, FTD patients with a higher educational attainment were able to cope better with greater brain damage. Determination of the most suitable activities to build an adequate level of CR is crucial for dementia prevention.

Please choose payment method:

(PDF emailed within 0-6 h: $19.90)

Accession: 055197066

Download citation: RISBibTeXText

PMID: 29514157

DOI: 10.1159/000486621

Related references

Revisiting brain reserve hypothesis in frontotemporal dementia: evidence from a brain perfusion study. Dementia and Geriatric Cognitive Disorders 28(2): 130-135, 2009

Beyond cognitive reserve: behavioural reserve hypothesis in Frontotemporal Dementia. Behavioural Brain Research 245: 58-62, 2013

Analysis of frontotemporal dementia, amyotrophic lateral sclerosis, and other dementia-related genes in 107 Korean patients with frontotemporal dementia. Neurobiology of Aging 72: 186.E1-186.E7, 2018

Frontotemporal Lobar Degeneration-Modified Clinical Dementia Rating (FTLD-CDR) Scale and Frontotemporal Dementia Rating Scale (FRS) Correlation With Regional Brain Perfusion in a Series of FTLD Patients. Journal of Neuropsychiatry and Clinical Neurosciences 29(1): 26-30, 2017

SQSTM1 mutations in French patients with frontotemporal dementia or frontotemporal dementia with amyotrophic lateral sclerosis. JAMA Neurology 70(11): 1403-1410, 2013

Presymptomatic cognitive and neuroanatomical changes in genetic frontotemporal dementia in the Genetic Frontotemporal dementia Initiative (GENFI) study: a cross-sectional analysis. Lancet. Neurology 14(3): 253-262, 2015

Male gender is associated with greater cerebral hypometabolism in frontotemporal dementia: evidence for sex-related cognitive reserve. International Journal of Geriatric Psychiatry 22(11): 1135-1140, 2007

Distinct patterns of medial temporal impairment in degenerative dementia: a brain SPECT perfusion study in Alzheimer's disease and frontotemporal dementia. European Journal of Nuclear Medicine and Molecular Imaging 40(6): 932-942, 2013

Cognitive reserve and TMEM106B genotype modulate brain damage in presymptomatic frontotemporal dementia: a GENFI study. Brain 140(6): 1784-1791, 2017

Role of semiquantitative assessment of regional binding potential in 123I-FP-CIT SPECT for the differentiation of frontotemporal dementia, dementia with Lewy bodies, and Alzheimer's dementia. Clinical Nuclear Medicine 40(1): E27, 2015

Neural Correlates Of Recognizing Negative Facial Emotions In Dementia: Evidence From Mild Cognitive Impairment, AlzheimerS Disease And Frontotemporal Dementia. Alzheimer's and Dementia 13(7): P1148-P1149, 2017

Italian Frontotemporal Dementia Network (FTD Group-SINDEM): sharing clinical and diagnostic procedures in Frontotemporal Dementia in Italy. Neurological Sciences 36(5): 751-757, 2015

Neuropsychiatric features of C9orf72-associated behavioral variant frontotemporal dementia and frontotemporal dementia with motor neuron disease. Alzheimer's Research and Therapy 4(5): 38-38, 2012

Clinical and pathological diagnosis of frontotemporal dementia: Report of the work group on frontotemporal dementia and Pick's disease. Archives of Neurology 58(11): 1803-1809, 2001

Dementia and neurodevelopmental predisposition: cognitive dysfunction in presymptomatic subjects precedes dementia by decades in frontotemporal dementia. Annals of Neurology 50(6): 741-746, 2001