+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Prognostic factors for loco-regional failure in early stage (I and II) squamous cell carcinoma of the gingivobuccal complex

Prognostic factors for loco-regional failure in early stage (I and II) squamous cell carcinoma of the gingivobuccal complex

European Archives of Oto-Rhino-Laryngology 267(7): 1135-1140

The objective of the article is to study the prognostic indicators of loco-regional failure in patients with early stage cancers of the gingivobuccal complex (GBC) treated at a single institution. The study design is based on retrospective chart review. A review of 2,275 patients diagnosed with GBC was conducted from January 1997 to December 1999, wherein 207 patients who fulfilled our inclusion criteria were analyzed. Univariate analysis, multivariate analysis, and disease-free survival are reported. During a median follow-up of 2.85 years there were 85 (43%) loco-regional failures of which 64% could be salvaged. As much as 80% of all failures occurred within the first 24 months and the mean survival for patients with recurrences was 9.6 months. Two and five-year disease-free survival for the entire cohort was 65% and 52%, respectively. Nodal metastasis, soft tissue infiltration, and pathological bone involvement correlated with poor disease-free survival on multivariate analysis. Early stage tumors of the GBC as evaluated clinically are often upstaged pathologically due to a high rate of occult nodal metastasis and local failure as they tend to invade bone and infiltrate adjacent soft tissue. Consequently, we recommend aggressive surgical therapy as we would recommend for advanced stage cancers of the GBC which includes a wide three-dimensional resection to account for soft tissue and bony infiltrations and adjuvant therapy in the presence of adverse features since salvage rates for recurrent tumors are poor.

Please choose payment method:

(PDF emailed within 0-6 h: $19.90)

Accession: 055209806

Download citation: RISBibTeXText

PMID: 20066453

DOI: 10.1007/s00405-009-1201-7

Related references

Squamous cell carcinoma of the gingivobuccal complex: predictors of locoregional failure in stage III-IV cancers. Oral Oncology 45(2): 135-140, 2008

Significance of Perineural Invasion in Regional Metastasis and Loco-Regional Recurrence in Early Stage Squamous Cell Carcinoma of the Oral Tongue. A Pilot Study. Journal of Oral and Maxillofacial Surgery 64(9-Supp-S): 28-29, 2006

Advanced squamous cell carcinoma of lower gingivobuccal complex: patterns of spread and failure. Head & Neck 27(7): 597-602, 2005

Prognostic factors for loco-regional control and outcome of re-irradiation for patients with poorly-differentiated squamous cell carcinoma of the nasopharynx. Japanese Journal of Clinical Oncology 25(3): 72-78, 1995

Prognostic Factors for Local, Loco-regional and Systemic Recurrence in Early-stage Breast Cancer. Geburtshilfe und Frauenheilkunde 75(7): 710-718, 2015

Factors related to regional recurrence in early stage squamous cell carcinoma of the oral tongue. Clinical and Experimental Otorhinolaryngology 1(3): 166-170, 2009

A confirmatory prognostic study on oxygenation status and loco-regional control in advanced head and neck squamous cell carcinoma treated by radiation therapy. Radiotherapy & Oncology 57(1): 39-43, October, 2000

Re: Development and External Validation of a Prognostic Tool for Prediction of Cancer-Specific Mortality after Complete Loco-Regional Pathological Staging for Squamous Cell Carcinoma of the Penis. Journal of Urology 196(4): 1128-1128, 2016

Development and external validation of a prognostic tool for prediction of cancer-specific mortality after complete loco-regional pathological staging for squamous cell carcinoma of the penis. Bju International 116(5): 734-743, 2016

Outcome and prognostic factors of 125 loco-regionally advanced head and neck squamous cell carcinoma treated with multi-modality treatment. Zhonghua Zhong Liu Za Zhi 36(3): 217-222, 2014

CD31 and VEGF are prognostic biomarkers in early-stage, but not in late-stage, laryngeal squamous cell carcinoma. Bmc Cancer 18(1): 272-272, 2018

Prognostic value of miR-375 and miR-214-3p in early stage oral squamous cell carcinoma. American Journal of Translational Research 6(5): 580-592, 2014

Prognostic analysis of early-stage squamous cell carcinoma of the vulva. World Journal of Surgical Oncology 11: 20-20, 2013

Pretreatment serum squamous cell carcinoma antigen: a newly identified prognostic factor in early-stage cervical carcinoma. Journal of Clinical Oncology 14(1): 111-118, 1996

Loco regional failure rate in relation with radiation dose in combined modality approach of multiagent chemotherapy and radiotherapy for limited stage small cell lung carcinoma. International Journal of Radiation Oncology, Biology, Physics 13(SUPPL 1): 188-189, 1987