+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Prognostic factors of tumor recurrence in completely resected non-small cell lung cancer



Prognostic factors of tumor recurrence in completely resected non-small cell lung cancer



Cancer Management and Research 5: 77-84



Patients with completely resected non-small cell lung cancer (NSCLC) have an excellent outcome; however tumor recurs in 30%-77% of patients. This study retrospectively analyzed the clinicopathologic features of patients with any operable stage of NSCLC to identify the prognostic factors that influence tumor recurrence, including intratumoral blood vessel invasion (IVI), tumor size, tumor necrosis, and intratumoral lymphatic invasion. From January 2002 to December 2011, 227 consecutive patients were enrolled in this study. They were divided into two groups: the "no recurrence" group and the "recurrence" group. Recurrence-free survival was analyzed by multivariable Cox regression analysis, stratified by tumor staging, chemotherapy, and nodal involvement. IVI, tumor necrosis, tumor diameter more than 5 cm, and nodal involvement were identified as independent prognostic factors of tumor recurrence. The hazard ratio (HR) of patients with IVI was 2.1 times higher than that of patients without IVI (95% confident interval [CI]: 1.4-3.2) (P = 0.001).The HR of patients with tumor necrosis was 2.1 times higher than that of patients without tumor necrosis (95% CI: 1.3-3.4) (P = 0.001). Patients who had a maximum tumor diameter greater than 5 cm had significantly higher risk of recurrence than patients who had a maximum tumor diameter of less than 5 cm (HR 1.9, 95% CI: 1.0-3.5) (P = 0.033). IVI, tumor diameter more than 5 cm, and tumor necrosis are prognostic factors of tumor recurrence in completely resected NSCLC. Therefore, NSCLC patients, with or without nodal involvement, who have one or more prognostic factors of tumor recurrence may benefit from adjuvant chemotherapy for prevention of tumor recurrence.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 055210551

Download citation: RISBibTeXText

PMID: 23785244

DOI: 10.2147/cmar.s45642


Related references

Prognostic factors in patients with postoperative brain recurrence from completely resected non-small cell lung cancer. Thoracic Cancer 6(1): 38-42, 2015

Prognostic factors and the significance of treatment after recurrence in completely resected stage I non-small cell lung cancer. Chest 143(6): 1626-1634, 2013

Prognostic factors for post-recurrence survival in patients with completely resected Stage I non-small-cell lung cancer. European Journal of Cardio-Thoracic Surgery 45(2): 262-267, 2014

Prognostic factors for post-recurrence survival in patients with completely resected Stage III (N2) non-small-cell lung cancer. European Journal of Cardio-Thoracic Surgery 54(3): 554-559, 2018

P1.08-066 Prognostic Factors of Post-Recurrence Survival in Patients with Completely Resected Stage Iii-N2 Non-Small Cell Lung Cancer. Journal of Thoracic Oncology 12(1): S771-S772, 2017

The prognostic value of ERCC1 and RRM1 gene expression in completely resected non-small cell lung cancer: tumor recurrence and overall survival. Cancer Management and Research 5: 327-336, 2013

The prognostic impact of preoperative PET-CT on postoperative recurrence for completely resected stage I non-small cell lung cancer. Zhonghua Wai Ke Za Zhi 53(7): 502-507, 2015

The prognostic impact of microRNA sequence polymorphisms on the recurrence of patients with completely resected non-small cell lung cancer. Journal of Thoracic and Cardiovascular Surgery 144(4): 794-807, 2012

Completely resected N1 non-small cell lung cancer: factors affecting recurrence and long-term survival. Journal of Thoracic and Cardiovascular Surgery 132(3): 499-506, 2006

Blood vessel invasion by tumor cells predicts recurrence in completely resected T1 N0 M0 non-small-cell lung cancer. Journal of Thoracic and Cardiovascular Surgery 106(1): 80-89, 1993

Analysis of prognostic factors in 1826 patients with completely resected non-small cell lung cancer. Zhonghua Zhong Liu Za Zhi 30(2): 134-137, 2008

Biological prognostic factors for early stage completely resected non-small cell lung cancer. Journal of Surgical Oncology 74(1): 53-60, 2000

Significant prognostic factors for completely resected pN2 non-small cell lung cancer without neoadjuvant therapy. Annals of Thoracic and Cardiovascular Surgery 21(4): 345-353, 2015

Completely resected n0 non-small cell lung cancer: prognostic factors affecting long-term survival. Isrn Surgery 2013: 175304, 2013

Prognostic Impact of Tumor Mutation Burden in Patients With Completely Resected Non-Small Cell Lung Cancer: Brief Report. Journal of Thoracic Oncology 13(8): 1217-1221, 2018