+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Prognostic impact of the metastatic lymph node ratio on survival in rectal cancer



Prognostic impact of the metastatic lymph node ratio on survival in rectal cancer



Annals of Coloproctology 29(3): 100-105



Lymph-node metastasis is the most important predictor of survival in stage III rectal cancer. The number of metastatic lymph nodes may vary depending on the level of specimen dissection and the total number of lymph nodes harvested. The aim of this study was to evaluate whether the lymph node ratio (LNR) is a prognostic parameter for patients with rectal cancer. A retrospective review of a database of rectal cancer patients was performed to determine the effect of the LNR on the disease-free survival (DFS) and the overall survival. Of the total 228 patients with rectal cancer, 55 patients with stage III cancer were eligible for analysis. Survival curves were estimated using the Kaplan-Meier method. Cox regression analyses, after adjustments for potential confounders, were used to evaluate the relationship between the LNR and survival. According to the cutoff point 0.15 (15%), the 2-year DFS was 95.2% among patients with a LNR < 0.15 compared with 67.6% for those with LNR ≥ 0.15 (P = 0.02). In stratified and multivariate analyses adjusted for age, gender, histology and tumor status, a higher LNR was independently associated with worse DFS. This study showed the prognostic significance of ratio-based staging for rectal cancer and may help in developing better staging systems. LNR 0.15 (15%) was shown to be a cutoff point for determining survival and prognosis in rectal cancer cases.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 055210984

Download citation: RISBibTeXText

PMID: 23862127


Related references

Prognostic Impact of the Metastatic Lymph Node Ratio on Survival in Gastric Cancer. Indian Journal of Surgical Oncology 7(1): 67-72, 2016

Prognostic implication of metastatic lymph node ratio in node-positive rectal cancer. Journal of the Korean Surgical Society 80(4): 260-266, 2011

Prognostic significance of the metastatic lymph node ratio in node-positive rectal cancer. Annals of Surgical Oncology 15(11): 3118-3123, 2008

Impact of Metastatic Lymph Node to Total Lymph Node Ratio on Survival of Endometrial Cancer Patients. Gynecologic and Obstetric Investigation 84(5): 463-471, 2019

Prognostic value of lymph node ratio in survival of patients with stage III rectal cancer. Zhonghua Zhong Liu Za Zhi 34(7): 506-509, 2012

Prognostic significance of metastatic lymph node ratio: the lymph node ratio could be a prognostic indicator for patients with gastric cancer. World Journal of Surgical Oncology 16(1): 198, 2018

Metastatic lymph node ratio in stage III rectal cancer; prognostic significance in addition to the 7th edition of the TNM classification. European Journal of Surgical Oncology 36(12): 1180-1186, 2010

Prognostic value of lymph node ratio in survival of patients with locally advanced rectal cancer. Canadian Journal of Surgery. Journal Canadien de Chirurgie 58(4): 237-244, 2015

Prognostic significance of the metastatic lymph node ratio for survival in colon cancer. Journal of BUON 16(3): 478-485, 2012

Metastatic lymph node ratio as a prognostic factor after laparoscopic total mesorectal excision for extraperitoneal rectal cancer. Surgical Endoscopy 27(6): 1957-1967, 2013

P-083 * Prognostic determinants in gastric cancer survival - the importance of metastatic lymph node ratio. Annals of Oncology 26(Suppl 4): Iv23-Iv23, 2015

Prognostic impact of the lymph node ratio in rectal cancer patients who underwent preoperative chemoradiation. Journal of Surgical Oncology 104(1): 53-58, 2011

Prognostic significance of the lymph node ratio regarding recurrence and survival in rectal cancer patients treated with postoperative chemoradiotherapy. Gut and Liver 6(2): 203-209, 2012

Prognostic impact of metastatic lymph node ratio in advanced gastric cancer from cardia and fundus. World Journal of Gastroenterology 14(27): 4383-4388, 2008

Prognostic impact of metastatic lymph node ratio on gastric cancer after curative distal gastrectomy. World Journal of Gastroenterology 16(16): 2055-2060, 2010