+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Prognostic role and significance of paraneoplastic syndromes in hepatocellular carcinoma



Prognostic role and significance of paraneoplastic syndromes in hepatocellular carcinoma



American Surgeon 80(2): 191-196



Patients with hepatocellular carcinoma (HCC) may develop paraneoplastic syndromes in the clinical course. These syndromes include hypercholesterolemia, hypoglycemia, hypercalcemia, and erythrocytosis, among others. This study was designed to assess the role of prognostic influence of paraneoplastic syndromes in patients with HCC. In a cohort of 175 patients with HCC patients, we compared the clinical features of patients with HCC with or without paraneoplastic syndromes. In addition, survival rates of patients with individual paraneoplastic syndromes and those without were also evaluated. Moreover, factors independently predicting prognosis among patients with HCC with or without paraneoplastic syndromes were analyzed. Among 175 patients with HCC, 54 patients presented paraneoplastic syndromes, and the prevalence was 30.9 per cent. There was no difference of clinical characteristics between patients with HCC with and without paraneoplastic syndromes on diagnosis. However, the patients with paraneoplastic syndromes had a significantly less survival rate comparing with those without during a 5-year follow-up. Cox regression analysis demonstrated that high Child-Pugh grade, large tumor size, portal vein tumor thrombosis, and distant metastasis were all independent unfavorable prognostic factors for survival of patients with HCC. Paraneoplastic syndromes as independent risk factors play a significant role in the progress of HCC and lead to poor prognosis in patients with HCC.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 055211780

Download citation: RISBibTeXText

PMID: 24480222


Related references

The incidence and clinical significance of paraneoplastic syndromes in patients with hepatocellular carcinoma. Korean Journal of Hepatology 11(3): 275-283, 2005

Epidemiology and prognosis of paraneoplastic syndromes in hepatocellular carcinoma. Isrn Oncology 2013: 684026, 2013

Paraneoplastic syndromes in patients with hepatocellular carcinoma in Taiwan. Cancer 86(5): 799-804, 1999

The incidence and characteristics of some paraneoplastic syndromes of hepatocellular carcinoma in Nigerian patients. European Journal of Gastroenterology and Hepatology 11(12): 1401-1404, 1999

Clinical characteristics and prognosis of hepatocellular carcinoma patients with paraneoplastic syndromes. Hepato-Gastroenterology 49(47): 1315-1319, 2002

The incidence and characteristics of some paraneoplastic syndromes of hepatocellular carcinoma in Nigerian patients. European Journal of Gastroenterology & Hepatology 11(12): 1401-1404, 1999

Clinicopathological significance and prognostic role of p-STAT3 in patients with hepatocellular carcinoma. Oncotargets and Therapy 11: 1203-1214, 2018

Prognostic significance of miR-218 in human hepatocellular carcinoma and its role in cell growth. Oncology Reports 32(4): 1571-1577, 2014

Paraneoplastic syndromes in patients with laryngeal neuroendocrine carcinomas: clinical manifestations and prognostic significance. European Archives of Oto-Rhino-Laryngology 273(3): 533-536, 2016

Histologic characteristics and prognostic significance in small hepatocellular carcinoma with biliary differentiation: subdivision and comparison with ordinary hepatocellular carcinoma. American Journal of Surgical Pathology 31(5): 783-791, 2007

Pleomorphic adenoma gene 1 mediates the role of karyopherin alpha 2 and has prognostic significance in hepatocellular carcinoma. Journal of Experimental and Clinical Cancer Research 33: 61, 2014

Antineuronal antibodies in small cell lung carcinoma--a significance for paraneoplastic syndromes?. Acta Neuropathologica 75(2): 199-202, 1987

Prognostic significance of preoperative prognostic nutritional index in hepatocellular carcinoma: a meta-analysis. Hpb 20(10): 888-895, 2018

Prognostic significance and characterization of paraneoplastic signs in renal cell carcinoma, the UCLA experience. Journal of Urology 169(4 Suppl.): 260, 2003

Prognostic significance of Bcl-xL in human hepatocellular carcinoma. Surgery 135(6): 604-612, 2004