+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Prognostic significance of molecular markers in oral squamous cell carcinoma: a multivariate analysis



Prognostic significance of molecular markers in oral squamous cell carcinoma: a multivariate analysis



Head and Neck 31(12): 1544-1556



Multiple marker accumulation impacts tumor progression and biologic phenotypes affect clinical outcome of patients with head and neck cancer. Hence, this study investigated a battery of molecular markers that may help to reflect biologic aggressiveness and predict prognosis. Epidermal growth factor receptor (EGFR), Stat3, H-ras, c-myc, p53, cyclin D1, p16, Rb, Ki-67, and Bcl-2 were localized immunohistochemically in 135 oral squamous cell carcinoma patients to assess prognostic value. In univariate analysis of total patients, p53, Stat3, and p16 predicted both relapse-free survival (RFS) and overall survival (OS). In Cox multivariate analysis, after adjusting for tumor size, nodal status, and lymphatic permeation, p53 was independently associated with RFS and OS, and p16 with RFS only. In only early-stage patients, in univariate analysis, nuclear Stat3 was significant for RFS and OS. Immunostaining of p53, p16, and Stat3 might serve as potential adjuncts in pathologic evaluation of oral tumors to predict risk of relapse.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 055212736

Download citation: RISBibTeXText

PMID: 19424974

DOI: 10.1002/hed.21126


Related references

Prognostic molecular markers in oral and lip squamous cell carcinoma--evaluation of expression and its significance. Otolaryngologia Polska 62(2): 175-181, 2008

Prognostic significance of neural stem cell markers, Nestin and Musashi-1, in oral squamous cell carcinoma: expression pattern of Nestin in the precancerous stages of oral squamous epithelium. Clinical Oral Investigations 19(6): 1251-1260, 2018

Prognostic significance of biomarkers in squamous cell carcinoma of the tongue: multivariate analysis. Journal of Surgical Oncology 82(1): 34-50, 2002

Cytogenetic significance of chromosome 17 aberrations and P53 gene mutations as prognostic markers in oral squamous cell carcinoma. Diagnostic Pathology 10: 2, 2016

Molecular markers in head and neck squamous cell carcinoma: their biological function and prognostic significance. Annals of Otology, Rhinology, and Laryngology 110(3): 221-228, 2001

Significance of molecular markers in survival prediction of oral squamous cell carcinoma. Head and Neck 34(7): 929-936, 2013

Prognostic factors and relative risk for survival in N1-3 oral squamous cell carcinoma: a multivariate analysis using Cox's hazard model. British Journal of Oral and Maxillofacial Surgery 37(6): 433-437, 2000

Univariate and multivariate analysis of prognostic significance of betel quid chewing in squamous cell carcinoma of buccal mucosa in Taiwan. Journal of Surgical Oncology 91(1): 41-47, 2005

Multivariate analysis of occult lymph node metastasis as a prognostic indicator for patients with squamous cell carcinoma of the oral cavity. Cancer 82(9): 1797-1799, 1998

Multivariate analysis of occult lymph node metastasis as a prognostic indicator for patients with squamous cell carcinoma of the oral cavity. Cancer. 80(3): 351-356, 1997

Short-term significance of Dna ploidy and cell proliferation in breast carcinoma: a multivariate analysis of prognostic markers in a series of 308 patients. Journal of Clinical Pathology 52(8): 604-611, 1999

Short-term significance of DNA ploidy and cell proliferation in breast carcinoma: a multivariate analysis of prognostic markers in a series of 308 patients. Journal of Clinical Pathology 52(8): 604-611, 2000

Clinicopathological and prognostic significance of PD-L1 expression in oral squamous cell carcinoma: a meta analysis. Shanghai Kou Qiang Yi Xue 27(1): 100-105, 2018

Clinicopathological and prognostic significance of p27 expression in oral squamous cell carcinoma: a meta-analysis. International Journal of Biological Markers 28(4): E329-E335, 2014

Clinical and prognostic significance of HIF-1α overexpression in oral squamous cell carcinoma: a meta-analysis. World Journal of Surgical Oncology 15(1): 104, 2017