+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Prognostic significance of p21 expression in patients with esophageal squamous cell carcinoma



Prognostic significance of p21 expression in patients with esophageal squamous cell carcinoma



Anticancer Research 33(10): 4329-4335



Although p21 is an important component that regulates cell-cycle progression, no consensus has been reached about its clinicopathological significance in esophageal squamous cell carcinoma (ESCC). In the present study, we investigated its prognostic significance and correlation with cyclin-D1 (CCND1) expression in ESCC. The p21 labeling index (LI) was calculated by immunohistochemistry for 69 primary tumor samples obtained from patients with ESCC who had undergone curative esophagectomy, and correlations between p21 LI and various clinicopathological features, prognosis, and CCND1 LI were studied. The p21 LI of these tumors ranged from 2.0% to 57.0% (median=28.4%, mean±SD=27.3% ± 13.0). p21 LI was positively correlated with CCND1 LI. When patients were divided into two groups using a p21 LI cut-off value of 30%, the 5-year survival rate of patients with p21 LI of ≥ 30% was 80.0%, which was significantly higher than that of patients with p21 LI of <30% (55.5%). Furthermore, when patients were divided into four groups according to p21 and CCND1 expression, the 5-year survival rate of patients with p21 LI of <30% and CCND1 LI of ≥ 45% was the lowest (44.4%). Multivariate analysis demonstrated that venous invasion, lymphatic invasion, and p21 LI were independent prognostic factors. Our results indicate that p21 LI is correlated with CCND1 LI and can be used as an independent prognostic factor for patients with ESCC following selection of a suitable cut-off value.

(PDF emailed within 1 workday: $29.90)

Accession: 055212813

Download citation: RISBibTeXText

PMID: 24123000


Related references

Prognostic significance of ICAM-1 expression in patients with esophageal squamous cell carcinoma. Proceedings of the American Association for Cancer Research Annual Meeting 42: 798, 2001

Expression and prognostic significance of PTEN product protein in patients with esophageal squamous cell carcinoma. Cancer 94(7): 1955-1960, April 1, 2002

Prognostic significance of high podoplanin expression after chemoradiotherapy in esophageal squamous cell carcinoma patients. Journal of Surgical Oncology 105(2): 183-188, 2012

Clinical and prognostic significance of MUC1 expression in patients with esophageal squamous cell carcinoma after radical resection. Saudi Journal of Gastroenterology 24(3): 165-170, 2018

Clinicopathological and prognostic significance of survivin over-expression in patients with esophageal squamous cell carcinoma: a meta-analysis. Plos One 7(9): E44764, 2013

Clinicopathological and prognostic significance of programmed cell death ligand 1 (PD-L1) expression in patients with esophageal squamous cell carcinoma: a meta-analysis. Journal of Thoracic Disease 8(11): 3197-3204, 2017

No prognostic significance of p53 expression in esophageal squamous cell carcinoma. Journal of Surgical Oncology 72(2): 94-98, 1999

Prognostic significance of dysadherin expression in esophageal squamous cell carcinoma. Oncology 67(1): 73-80, 2004

FOXA1 and CK7 expression in esophageal squamous cell carcinoma and its prognostic significance. Neoplasma 65(3): 469-476, 2018

Prognostic significance of nm23-H1 expression in esophageal squamous cell carcinoma. European Journal of Cardio-Thoracic Surgery 26(2): 419-424, 2004

Expression and prognostic significance of MYL9 in esophageal squamous cell carcinoma. Plos One 12(4): E0175280, 2017

Connective tissue growth factor expression in precancerous lesions of human esophageal epithelium and prognostic significance in esophageal squamous cell carcinoma. Diseases of the Esophagus 24(5): 337-345, 2016

Prognostic Significance of the Prognostic Nutritional Index in Patients with Recurrent Esophageal Squamous Cell Carcinoma. Nutrition and Cancer 70(3): 467-473, 2018

Prognostic significance of Glasgow prognostic score in patients undergoing esophagectomy for esophageal squamous cell carcinoma. Saudi Journal of Gastroenterology 20(1): 48-53, 2014

Increased expression of S100A4 and its prognostic significance in esophageal squamous cell carcinoma. International Journal of Oncology 18(4): 715-720, 2001