+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Prognostic significance of the hair follicle stem cell marker nestin in patients with malignant melanoma

Prognostic significance of the hair follicle stem cell marker nestin in patients with malignant melanoma

European Journal of Dermatology 20(3): 283-288

Nestin is an intermediate filament protein, and serves as a hair follicle stem cell and neural stem cell marker. Recent studies have suggested that nestin expression is also important for tumorigenesis. Previous reports from our laboratory have revealed that nestin is a marker of HMB-45-negative melanoma cells in dermal invasive lesions of nodular malignant melanoma. The present study examines nestin expression in malignant melanoma and investigates the relationship between nestin expression and prognosis in patients. We immunohistochemically stained 78 formalin-fixed and paraffin-embedded malignant melanomas for nestin, HMB-45 and S100 reactivity. We found that nestin, HMB-45 and S100 protein were detected in 56.5%, 88.4% and 100% of malignant melanomas, respectively. The 5-year survival rate of stage I and II nestin-positive cases was significantly decreased compared to the nestin-negative cases (p < 0.05). In addition, the 5-year survival rate exceeded 80% in nestin-negative malignant melanomas at all stages of tumor development. We conclude that nestin expression may be a predictor of poor prognosis in patients with malignant melanoma.

Please choose payment method:

(PDF emailed within 0-6 h: $19.90)

Accession: 055213062

Download citation: RISBibTeXText

PMID: 20156773

DOI: 10.1684/ejd.2010.0909

Related references

Hair follicle stem cell marker nestin expression in regenerating hair follicles of patients with alopecia areata. European Journal of Dermatology 21(2): 209-212, 2011

The neuroepithelial stem cell protein nestin is a marker of the companion cell layer of the adult and developing human hair follicle. British Journal of Dermatology 161(3): 678-682, 2010

Expression of the stem cell marker nestin in peripheral blood of patients with melanoma. British Journal of Dermatology 163(1): 107-114, 2010

Protocols for Cryopreservation of Intact Hair Follicle That Maintain Pluripotency of Nestin-Expressing Hair-Follicle-Associated Pluripotent (HAP) Stem Cells. Methods in Molecular Biology 1453: 173-178, 2018

Cryopreservation of the Hair Follicle Maintains Pluripotency of Nestin-Expressing Hair Follicle-Associated Pluripotent Stem Cells. Tissue Engineering. Part C, Methods 21(8): 825-831, 2016

Rat hair follicle-constituting cells labeled by a newly-developed somatic stem cell-recognizing antibody: a possible marker of hair follicle development. Histology and Histopathology 28(2): 257-268, 2013

Prognostic significance of nestin in primary malignant melanoma of the oral cavity. Melanoma Research 26(5): 457-463, 2018

Expression of the hair stem cell-specific marker nestin in epidermal and follicular tumors. European Journal of Dermatology 18(5): 518-523, 2008

Prognostic significance of neural stem cell markers, Nestin and Musashi-1, in oral squamous cell carcinoma: expression pattern of Nestin in the precancerous stages of oral squamous epithelium. Clinical Oral Investigations 19(6): 1251-1260, 2014

The stem cell marker nestin predicts poor prognosis in human melanoma. Oncology Reports 23(1): 17-24, 2010

A cellular marker for the human hair follicle bulge identifies hair follicle stem cells. Journal of Dermatological Science 16(SUPPL 1): S19, March, 1998

Nestin expression in hair follicle stem cells. Journal of Investigative Dermatology 119(1): 291, July, 2002

Nestin-expressing hair follicle stem cells. Journal of Investigative Dermatology 121(1): 0834, July, 2003

Prognostic significance of stem cell marker CD133 determined by promoter methylation but not by immunohistochemical expression in malignant gliomas. Journal of Neuro-Oncology 127(2): 221-232, 2016

Multipotent nestin-expressing hair follicle stem cells. Journal of Dermatology 36(1): 1-9, 2009