+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Prognostic value of a cell cycle progression score for men with prostate cancer



Prognostic value of a cell cycle progression score for men with prostate cancer



Recent Results in Cancer Research. Fortschritte der Krebsforschung. Progres Dans les Recherches sur le Cancer 202: 133-140



A new prognostic score called the cell cycle progression or CCP score has been evaluated for predicting outcome in men with prostate cancer. The score is based on 31 cell cycle progression genes and 15 housekeeper control genes. Results on 5 cohorts have been reported. In all cases the CCP score was strongly predictive of outcome both in univariate models and in multvariate models incorporating standard factors such as Gleason grade, PSA levels and extent of disease. Two cohorts evaluated patients managed by active surveillance where the outcome was death from prostate cancer, two cohorts examined patients treated by radical prostatectomy where biochemical recurrence was the primary endpoint, and one smaller cohort looked at patients treated with radiotherapy where again biochemical recurrence was used as the endpoint. In all cases a unit change in CCP score was associated with an approximate doubling of risk of an event. These data provide strong event to support use of the CCP score to help guide clinical management.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 055213640

Download citation: RISBibTeXText

PMID: 24531787

DOI: 10.1007/978-3-642-45195-9_16


Related references

Prognostic value of a cell-cycle progression score in men with prostate cancer managed with active surveillance after MRI-guided prostate biopsy--a pilot study. Anticancer Research 34(5): 2459-2466, 2014

Prognostic Value of the Cell Cycle Progression Score in Patients with Prostate Cancer: A Systematic Review and Meta-analysis. European Urology 69(1): 107-115, 2016

Prognostic utility of cell cycle progression score in men with prostate cancer after primary external beam radiation therapy. International Journal of Radiation Oncology Biology Physics 86(5): 848-853, 2013

Cell cycle progression score and treatment decisions in prostate cancer: results from an ongoing registry. Current Medical Research and Opinion 30(6): 1025-1031, 2014

Re: Validation of an RNA Cell Cycle Progression Score for Predicting Death from Prostate Cancer in a Conservatively Managed Needle Biopsy Cohort. Journal of Urology 195(6): 1779-1780, 2016

Prognostic utility of cell cycle progession score in men with prostate cancer after primary external beam radiation therapy. In regard to Freedland et al. International Journal of Radiation Oncology, Biology, Physics 88(1): 237-240, 2014

Gleason score and PSA as prognostic markers of prostate cancer progression. Proceedings of the American Association for Cancer Research Annual Meeting 42: 228, 2001

Soy milk digestion extract inhibits progression of prostate cancer cell growth via regulation of prostate cancer‑specific antigen and cell cycle-regulatory genes in human LNCaP cancer cells. Molecular Medicine Reports 14(2): 1809-1816, 2016

Prognostic utility of the cell cycle progression score generated from biopsy in men treated with prostatectomy. Journal of Urology 192(2): 409-414, 2014

Multiparametric Magnetic Resonance Imaging Predicts Postoperative Pathology but Misses Aggressive Prostate Cancers as Assessed by Cell Cycle Progression Score. Journal of Urology 194(6): 1617-1623, 2015

Mitochondrial function score combined with Gleason score for predicting the progression of prostate cancer. Zhonghua Nan Ke Xue 16(3): 220-222, 2010

Cell cycle progression score predicts metastatic progression of clear cell renal cell carcinoma after resection. Cancer Biomarkers 15(6): 861-867, 2015

Elevated AKR1C3 expression promotes prostate cancer cell survival and prostate cell-mediated endothelial cell tube formation: implications for prostate cancer progression. Bmc Cancer 10: 672, 2010

WWOX suppresses prostate cancer cell progression through cyclin D1-mediated cell cycle arrest in the G1 phase. Cell Cycle 14(3): 408-416, 2015

Effect of flavonoids on cell cycle progression in prostate cancer cells. Cancer Letters 176(1): 17-23, 2002