+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Progress on development and research of coronavirus based vector



Progress on development and research of coronavirus based vector



Bing du Xue Bao 28(3): 297-302



Due to the progress of targeted recombination and reverse genetics technique, it is possible to express foreign genes using coronaviruses as a vector via its unique transcription mechanism. Two types of coronavirus-based expression vectors have been developed; one is helper-dependent expression system and the other a single genome-based expression system. By modification of the infectious cDNA of the genome of coronaviruse, it has led to an efficient (> 50 microg/10(6)cells) and stable (> 30 passages) expression of the foreign gene. Moreover,several other features of coronavirus make it attractive as a vector. Firstly, the virulent coronaviruse can be converted into nonvirulent viruse by deleting the nonessential, group-specific genes. Secondly, the species and tissue tropism of coronaviruses can be manipulated by modification of their attachment and fusion protein S. Thus, coronavirus-based vector is becoming a promising and useful tool for vaccine development and gene delivery.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 055218705

Download citation: RISBibTeXText

PMID: 22764535


Related references

Development of a nucleocapsid-based human coronavirus immunoassay and estimates of individuals exposed to coronavirus in a U.S. metropolitan population. Clinical and Vaccine Immunology 15(12): 1805-1810, 2008

Multigene RNA vector based on coronavirus transcription. Journal of Virology 77(18): 9790-9798, 2003

Research progress in functions of coronavirus accessory genes. Bing du Xue Bao 30(3): 325-332, 2014

Development of a cervical cancer progress prediction tool for human papillomavirus-positive Koreans: A support vector machine-based approach. Journal of International Medical Research 43(4): 518-525, 2015

Recent progress in research and development of RNA-based pharmaceuticals. Tanpakushitsu Kakusan Koso. Protein, Nucleic Acid, Enzyme 51(13): 1889-1894, 2006

A survey of research progress and development tendency of attribute-based encryption. Thescientificworldjournal 2014: 193426, 2014

Development of a coronavirus rna vector to study the signals involved in genome encapsidation and messenger rna synthesis. Journal of Cellular Biochemistry Suppl. 15(Part E): 92, 1991

Generation of a replication-competent, propagation-deficient virus vector based on the transmissible gastroenteritis coronavirus genome. Journal of Virology 76(22): 11518-11529, 2002

Research toward the development of a biologically based dose response assessment for inorganic arsenic carcinogenicity: a progress report. Toxicology and Applied Pharmacology 222(3): 388-398, 2007

Progress of research on the vector(s) of lethal yellowing. Oleagineux 35: 300-301, 1980

Research progress on malaria vector control. Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi 25(3): 312-5 319, 2013

Progress in the research on the techniques for surveillance of filariasis vector. Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi 19(1): 48-51, 2001

Progress in research on cationic polymers as gene vector. Zhejiang Da Xue Xue Bao. Yi Xue Ban 41(6): 593-598, 2012

Research progress on the effect of climate change on dengue vector. Zhonghua Liu Xing Bing Xue Za Zhi 34(7): 745-749, 2013

Progress in research of chitosan as a non-viral gene delivery vector. Yi Chuan 28(10): 1321-1324, 2006