+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Prospective, randomized, controlled comparison of SYSTANE UD eye drops versus VISINE INTENSIV 1% EDO eye drops for the treatment of moderate dry eye



Prospective, randomized, controlled comparison of SYSTANE UD eye drops versus VISINE INTENSIV 1% EDO eye drops for the treatment of moderate dry eye



Journal of Ocular Pharmacology and Therapeutics 28(6): 598-603



The aim of this prospective, randomized, clinical, single-center study was to compare the safety and efficacy of 2 ocular surface lubricant eye drops: preservative-free hydroxypropyl (HP)-Guar (SYSTANE UD(®)) eye drops versus preservative-free Tamarindus indica seed polysaccharide (TSP) 1% (VISINE INTENSIV 1% EDO(®)) eye drops. Fifty-six eyes of 28 patients with moderate keratoconjunctivitis sicca (DEWS severity level 2) were enrolled in the trial. Patients were randomized for 2 treatment groups (SYSTANE UD eye drops vs. VISINE INTENSIV 1% EDO eye drops). The eye drops in both groups were applied 5 times per day for 3 months. Statistical analyses were performed using Statistica™ software (Mann-Whitney U-test and Wilcoxon test). P-Values<0.05 were considered significant. After 3 months of treatment the patients of both groups had subjective benefit in the relief of symptoms of dry eye disease evaluated by the Ocular Surface Disease Index (OSDI) questionnaire score. Patients treated with HP-Guar and TSP showed improvements in tear film stability measured by tear break-up time (TBUT), which are statistically significant in the HP-Guar group (P=0.02). The results of this clinical trial show improvements of symptoms and signs in patients with moderate dry eye after the consistent use of preservative-free HP-Guar and TSP lubricant eye drops. Both artificial tear formulations produce amelioration in tear film stability improving eye conditions and patient quality of life. HP-Guar seems to be slightly more effective in improving ocular surface protection by decreasing tear film evaporation.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 055238457

Download citation: RISBibTeXText

PMID: 22813209

DOI: 10.1089/jop.2012.0066


Related references

A Two-Week, Randomized, Double-masked Study to Evaluate Safety and Efficacy of Lubricin (150 μg/mL) Eye Drops Versus Sodium Hyaluronate (HA) 0.18% Eye Drops (Vismed®) in Patients with Moderate Dry Eye Disease. Ocular Surface 15(1): 77-87, 2017

Comparison of novel lipid-based eye drops with aqueous eye drops for dry eye: a multicenter, randomized controlled trial. Clinical Ophthalmology 9: 657-664, 2015

Part 1 Randomized prospective controlled trial of ferrous sulfate drops versus micronencapsulated ferrous fumarate Sprinkles for treatment of anemia in Ghanaian infants and young children. FASEB Journal 15(4): A635, 2001

Clinical evaluation of twice-daily emedastine 0.05% eye drops (emadine eye drops) versus levocabastine 0.05% eye drops in patients with allergic conjunctivitis. American Journal of Ophthalmology 131(6): 691-698, 2001

Eye drops visine in the treatment of allergic conjunctivitis. Immunologiya 0(2): 36-37, 1995

A randomized clinical evaluation of the safety of Systane Lubricant Eye Drops for the relief of dry eye symptoms following LASIK refractive surgery. Clinical Ophthalmology 2(4): 973-979, 2008

Treatment of adenoviral keratoconjunctivitis with a combination of povidone-iodine 1.0% and dexamethasone 0.1% drops: a clinical prospective controlled randomized study. Acta Ophthalmologica 95(8): E686-E692, 2017

Poster 38 - Prospective Case History Study Using Systane Lubricant Eye Drops to Help Reduce Symptoms of Dry Eye Associated with Contact Lens Wear. Optometry - Journal of the American Optometric Association 75(6): 372-373, 2004

Randomized, controlled trial of single versus 3-times-daily ferrous sulfate drops for treatment of anemia. Pediatrics 108(3): 613-616, 2001

Poster 77 - A Comparison of Performance Attributes Between a New Concept Artificial Tear and Systane Lubricant Eye Drops. Optometry - Journal of the American Optometric Association 76(6): 392-393, 2005

Corneal staining reductions observed after treatment with Systane Lubricant Eye Drops. Advances in Therapy 25(11): 1191-1199, 2008

Autologous serum versus hyaluronic acid eye drops for the treatment of corneal erosions after vitrectomy in diabetic patients. A prospective randomized study. Der Ophthalmologe 102(9): 863-868, 2005

Systane® ultra lubricant eye drops for treatment of contact lens-related dryness. Eye and Contact Lens 40(2): 106-110, 2014

Comparison of azelastine eye drops with levocabastine eye drops in the treatment of seasonal allergic conjunctivitis. Current Medical Research and Opinion 16(3): 153-163, 2000

Effects of travoprost eye drops on intraocular pressure and pulsatile ocular blood flow: a 180-day, randomized, double-masked comparison with latanoprost eye drops in patients with open-angle glaucoma. Current Therapeutic Research Clinical and Experimental 64(7): 389-400, 2003