+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Proton magnetic resonance spectroscopy (MRS) in on-line game addiction



Proton magnetic resonance spectroscopy (MRS) in on-line game addiction



Journal of Psychiatric Research 58: 63-68



Recent brain imaging studies suggested that both the frontal and temporal cortices are important candidate areas for mediating the symptoms of internet addiction. We hypothesized that deficits of prefrontal and temporal cortical function in patients with on-line game addiction (PGA) would be reflected in decreased levels of N-acetyl aspartate (NAA) and cytosolic, choline containing compound (Cho). Seventy three young PGA and 38 age and sex matched healthy control subjects were recruited in the study. Structural MR and (1)H MRS data were acquired using a 3.0 T MRI scanner. Voxels were sequentially placed in right frontal cortex and right medial temporal cortices. In the right frontal cortex, the levels of NAA in PGA were lower than those in healthy controls. In the medial temporal cortex, the levels of Cho in PGA participants were lower than those observed in healthy controls. The Young Internet Addiction Scale (YIAS) scores and perseverative responses in PGA were negatively correlated with the level of NAA in right frontal cortex. The Beck Depressive Inventory (BDI) scores in the PGA cohort were negatively correlated with Cho levels in the right temporal lobe. To the best of our knowledge, this is the first MRS study of individuals with on-line game addiction. Although, the subjects with on-line game addiction in the current study were free from psychiatric co-morbidity, patients with on-line game addiction appear to share characteristics with ADHD and MDD in terms of neurochemical changes in frontal and temporal cortices.

(PDF emailed within 0-6 h: $19.90)

Accession: 055260112

Download citation: RISBibTeXText

PMID: 25088284

DOI: 10.1016/j.jpsychires.2014.07.007


Related references

In vitro proton magnetic resonance spectroscopy of liver tissue informs in vivo hepatic proton magnetic resonance spectroscopy studies. Hepatology 48(3): 1016; Author Reply 1016-7, 2008

Size-exclusion chromatography with on-line ultraviolet, proton nuclear magnetic resonance and mass spectrometric detection and on-line collection for off-line Fourier transform infrared spectroscopy. Journal of Chromatography. a 857(1-2): 89-96, 1999

Proton magnetic resonance spectroscopy of plasma from patients with dyslipoproteinemia: identification of factors governing methyl and methylene proton line widths. Journal of Lipid Research 30(4): 521-528, 1989

Neurochemical correlates of internet game play in adolescents with attention deficit hyperactivity disorder: A proton magnetic resonance spectroscopy (MRS) study. Psychiatry Research. Neuroimaging 254: 10-17, 2017

Effect of triglyceride levels on methyl and methylene envelope line widths in proton nuclear magnetic resonance spectroscopy of human plasma. New England Journal of Medicine 321(20): 1409-1412, 1989

Proton nuclear magnetic resonance spectroscopy reveals cellular lipids involved in resistance to adriamycin and taxol by the K562 leukemia cell line. Cancer Research 56(15): 3461-3467, 1996

Proton magnetic resonance spectroscopy and white matter hyperintensities on magnetic resonance imaging in patients with Alzheimer's disease. Annals of the New York Academy of Sciences 977: 423-429, 2002

Dynamic magnetic resonance tomography and proton magnetic resonance spectroscopy of prostate cancers in rats treated by radiotherapy. Investigative Radiology 39(1): 34-44, 2004

Proton magnetic resonance imaging and phosphorus-31 magnetic resonance spectroscopy studies of bromobenzene-induced liver damage in the rat. Magnetic Resonance Imaging 10(2): 257-267, 1992

Early diagnosis of avascular necrosis of the femoral head by magnetic resonance imaging and proton magnetic resonance spectroscopy. Journal of the Osaka City Medical Center 41(2): 431-445, 1992

The response of the rat liver in situ to bromobenzene--in vivo proton magnetic resonance imaging and 31P magnetic resonance spectroscopy studies. Toxicology and Applied Pharmacology 110(3): 416-428, 1991

Panencephalitic Creutzfeldt-Jakob disease. Unusual presentation of magnetic resonance imaging and proton magnetic resonance spectroscopy. Journal of the Neurological Sciences 138(1-2): 157-160, 1996

Proton magnetic resonance spectroscopy and magnetic resonance imaging findings in a patient with central nervous system paracoccidioidomycosis. Journal of Neuroimaging 14(4): 377-379, 2004

Evaluation of mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes with magnetic resonance imaging and proton magnetic resonance spectroscopy. Chinese Medical Sciences Journal 21(4): 234-238, 2007

Nuclear magnetic resonance spectroscopy applied to minerals; Part 6, Structural iron in kaolinites as viewed by proton magnetic resonance. Faraday Transactions 1 84(1): 117-132, 1988