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Proton magnetic resonance spectroscopy in multiple sclerosis



Proton magnetic resonance spectroscopy in multiple sclerosis



Neuroimaging Clinics of North America 19(1): 45-58



Proton magnetic resonance spectroscopy ((1)H-MRS) provides tissue metabolic information in vivo. This article reviews the role of MRS-determined metabolic alterations in lesions, normal-appearing white matter, gray matter, and spinal cord in advancing our knowledge of pathologic changes in multiple sclerosis (MS). In addition, the role of MRS in objectively evaluating therapeutic efficacy is reviewed. This potential metabolic information makes MRS a unique tool to follow MS disease evolution, understand its pathogenesis, evaluate the disease severity, establish a prognosis, and objectively evaluate the efficacy of therapeutic interventions.

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Accession: 055260142

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PMID: 19064199

DOI: 10.1016/j.nic.2008.08.002


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