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Proton magnetic resonance spectroscopy of the thalamus and hypothalamus in patients with first-episode depression



Proton magnetic resonance spectroscopy of the thalamus and hypothalamus in patients with first-episode depression



Nan Fang Yi Ke Da Xue Xue Bao 29(12): 2442-2445



To investigate the presence of abnormal metabolism in the thalamus and hypothalamus in patients with first-episode depression. Thirty drug-naive patients with first-episode depression and 30 age-matched controls were scanned with proton magnetic resonance spectroscopy ((1)H-MRS) for Naa, Cho, Cr and mI. Compared with the control group, the patients showed significantly reduced mI and mI/Cr of the hypothalamus, reduced mI/Cr of the left thalamus, and lowered Cho, ml, and ml/Cr of the right thalamus (P<0.05). Patients with first-episode depression may have myo-inositol and phosphoric acid metabolism disorder in the thalamus and hypothalamus with malfunction of cellular osmotic pressure adjustment mechanism. Abnormal mI/Cr in the thalamus and hypothalamus may represent an important biochemical change in advanced patients with depression.

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Accession: 055260173

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PMID: 20034897


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