+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Psychosocial risk markers for new onset irritable bowel syndrome--results of a large prospective population-based study



Psychosocial risk markers for new onset irritable bowel syndrome--results of a large prospective population-based study



Pain 137(1): 147-155



Irritable bowel syndrome (IBS) affects up to 22% of the general population. Its aetiology remains unclear. Previously reported cross-sectional associations with psychological distress and depression are not fully understood. We hypothesised that psychosocial factors, particularly those associated with somatisation, would act as risk markers for the onset of IBS. We conducted a community-based prospective study of subjects, aged 25-65 years, randomly selected from the registers of three primary care practices. Responses to a detailed questionnaire allowed subjects' IBS status to be classified using a modified version of the Rome II criteria. The questionnaire also included validated psychosocial instruments. Subjects free of IBS at baseline and eligible for follow-up 15 months later formed the cohort for this analysis (n=3732). An adjusted participation rate of 71% (n=2456) was achieved at follow-up. 3.5% (n=86) of subjects developed IBS. After adjustment for age, gender and baseline abdominal pain status, high levels of illness behaviour (odds ratio (OR)=5.2; 95% confidence interval (95% CI) 2.5-11.0), anxiety (OR=2.0; 95% CI 0.98-4.1), sleep problems (OR=1.6; 95% CI 0.8-3.2), and somatic symptoms (OR=1.6; 95% CI 0.8-2.9) were found to be independent predictors of IBS onset. This study has demonstrated that psychosocial factors indicative of the process of somatisation are independent risk markers for the development of IBS in a group of subjects previously free of IBS. Similar relationships are observed in other "functional" disorders, further supporting the hypothesis that they have similar aetiologies.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 055277025

Download citation: RISBibTeXText

PMID: 17928145

DOI: 10.1016/j.pain.2007.08.029


Related references

Psychosocial risk factors for the onset of abdominal pain. Results from a large prospective population-based study. International Journal of Epidemiology 31(6): 1219-1225, 2002

Psychosocial risk factors for the onset of abdominal pain. Results from a large prospective population-based study. International Journal of Epidemiology 31(6): 1219-25; Discussion 1225-6, 2003

Somatization an independent psychosocial risk factor for irritable bowel syndrome but not dyspepsia: a population-based study. European Journal of Gastroenterology and Hepatology 18(10): 1101-1109, 2006

Biliary events and an increased risk of new onset irritable bowel syndrome a population-based cohort study. Alimentary Pharmacology and Therapeutics 28(3): 334-343, 2008

Widespread hyperalgesia in adolescents with symptoms of irritable bowel syndrome: results from a large population-based study. Journal of Pain 15(9): 898-906, 2015

An Initial Attack of Urinary Stone Disease Is Associated with an Increased Risk of Developing New-Onset Irritable Bowel Syndrome: Nationwide Population-Based Study. Plos One 11(6): E0157701, 2017

Tu1440 Hormonal Factors and Risk of Irritable Bowel Syndrome in a Large Prospective Study of Women. Gastroenterology 142(5): S-833, 2012

A population-based case-control study of work and psychosocial problems in patients with irritable bowel syndrome--women are more seriously affected than men. American Journal of Gastroenterology 102(2): 371-379, 2006

Prevalence and demographics of irritable bowel syndrome: results from a large web-based survey. Alimentary Pharmacology and Therapeutics 22(10): 935-942, 2005

Irritable Bowel Syndrome Increases the Risk of Epilepsy: A Population-Based Study. Medicine 94(36): E1497, 2015

Antibiotics: a risk factor for irritable bowel syndrome in a population-based cohort. Scandinavian Journal of Gastroenterology 53(9): 1027-1030, 2018

Psychosocial factors in the irritable bowel syndrome. A multivariate study of patients and nonpatients with irritable bowel syndrome. Gastroenterology 95(3): 701-708, 1988

Risk of cancer in patients with irritable bowel syndrome: a nationwide population-based study. Annals of Epidemiology 25(12): 924-928, 2016

Irritable Bowel Syndrome Is Associated with an Increased Risk of Dementia: A Nationwide Population-Based Study. Plos One 11(1): E0144589, 2016

The epidemiology of irritable bowel syndrome: Symptom development over a 3-year period in Denmark. A prospective, population-based cohort study. Neurogastroenterology and Motility 29(4), 2016