+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Quantitative evaluation of the disintegration of orally rapid disintegrating tablets by X-ray computed tomography



Quantitative evaluation of the disintegration of orally rapid disintegrating tablets by X-ray computed tomography



Chemical and Pharmaceutical Bulletin 60(12): 1502-1507



To measure the rapid disintegration of Oral Disintegrating Tablets (ODT), a new test (XCT) was developed using X-ray computing tomography (X-ray CT). Placebo ODT, rapid disintegration candy (RDC) and Gaster®-D-Tablets (GAS) were used as model samples. All these ODTs were used to measure oral disintegration time (DT) in distilled water at 37±2°C by XCT. DTs were affected by the width of mesh screens, and degree to which the tablet holder vibrated from air bubbles. An in-vivo tablet disintegration test was performed for RDC using 11 volunteers. DT by the in-vivo method was significantly longer than that using the conventional tester. The experimental conditions for XCT such as the width of the mesh screen and degree of vibration were adjusted to be consistent with human DT values. Since DTs by the XCT method were almost the same as the human data, this method was able to quantitatively evaluate the rapid disintegration of ODT under the same conditions as inside the oral cavity. The DTs of four commercially available ODTs were comparatively evaluated by the XCT method, conventional tablet disintegration test and in-vivo method.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 055321769

Download citation: RISBibTeXText

PMID: 23006519


Related references

Evaluation of disintegration properties of orally rapidly disintegrating tablets using a novel disintegration tester. Chemical and Pharmaceutical Bulletin 60(10): 1240-1248, 2012

Evaluation of Disintegration Properties of Orally Rapidly Disintegrating Tablets Using a Novel Disintegration Tester. Chemical & Pharmaceutical Bulletin 60(10): 1240-1248, 2012

Evaluation of co-processed excipients used for direct compression of orally disintegrating tablets (ODT) using novel disintegration apparatus. Pharmaceutical Development and Technology 18(2): 464-474, 2013

Evaluation of the palatabilities in 10 different famotidine orally disintegrating tablets by combination of disintegration device and taste sensor. Drug Development and Industrial Pharmacy 41(8): 1387-1392, 2015

The practical approach to the evaluation of methods used to determine the disintegration time of orally disintegrating tablets (ODTs). Saudi Pharmaceutical Journal 23(4): 437-443, 2015

Evaluation of palatability of 10 commercial amlodipine orally disintegrating tablets by gustatory sensation testing, OD-mate as a new disintegration apparatus and the artificial taste sensor. Journal of Pharmacy and Pharmacology 65(9): 1312-1320, 2013

Development of a new disintegration method for orally disintegrating tablets. Chemical and Pharmaceutical Bulletin 58(7): 885-890, 2010

Evaluation of the disintegration properties of commercial famotidine 20 mg orally disintegrating tablets using a simple new test and human sensory test. Chemical & Pharmaceutical Bulletin 54(8): 1072-1075, 2006

Clinical disintegration time of orally disintegrating tablets clinically available in Japan in healthy volunteers. Biological and Pharmaceutical Bulletin 36(9): 1488-1493, 2013

Clinical Disintegration Time of Orally Disintegrating Tablets Clinically Available in Japan in Healthy Volunteers. Biological & Pharmaceutical Bulletin 36(9): 1488-1493, 2013

Acceptability and disintegration rates of orally disintegrating risperidone tablets in patients with schizophrenia or schizoaffective disorder. Canadian Journal of Psychiatry. Revue Canadienne de Psychiatrie 49(10): 701-703, 2004

PP006Clinical disintegration time and volume of water required for orally disintegrating tablets in healthy volunteers. Clinical Therapeutics 35(8): E18-E19, 2013

Development of fast disintegrating compressed tablets using amino acid as disintegration accelerator: evaluation of wetting and disintegration of tablet on the basis of surface free energy. Chemical & Pharmaceutical Bulletin 53(12): 1536-1539, 2005

A novel and discriminative method of in vitro disintegration time for preparation and optimization of taste-masked orally disintegrating tablets of carbinoxamine maleate. Drug Development and Industrial Pharmacy 44(8): 1317-1327, 2018

A new modified wetting test and an alternative disintegration test for orally disintegrating tablets. Journal of Pharmaceutical and Biomedical Analysis 120: 391-396, 2016