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RANKL expression in periodontal disease: where does RANKL come from?



RANKL expression in periodontal disease: where does RANKL come from?



Biomed Research International 2014: 731039-731039



Periodontitis is an inflammatory disease characterized by periodontal pocket formation and alveolar bone resorption. Periodontal bone resorption is induced by osteoclasts and receptor activator of nuclear factor-κB ligand (RANKL) which is an essential and central regulator of osteoclast development and osteoclast function. Therefore, RANKL plays a critical role in periodontal bone resorption. In this review, we have summarized the sources of RANKL in periodontal disease and explored which factors may regulate RANKL expression in this disease.

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Accession: 055333162

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PMID: 24719884

DOI: 10.1155/2014/731039



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